Neuraltransplantation in Neurodegnerative Disease - Current Status and New Directions (Novartis Foundation Symposium 231)

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed.This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions. Cell Replacement Strategies For Neurodegenerative Disorders / Anders Björklund -- Functional Analysis Of Fronto-striatal Reconstruction By Striatal Grafts / Stephen B. Dunnett -- Functional Reconstruction Of The Hippocampus : Fetal Versus Conditionally Immortal Neuroepithelial Stem Cell Grafts / H. Hodges, P. Sowinski, D. Virley, A. Nelson, T.r. Kershaw, W.p. Watson, T. Veizovic, S. Patel, A. Mora, T. Rashid, S.j. French, A. Chadwick, J.a. Gray And J.d. Sinden -- Gene Transfer For Neuroprotection In Animal Models Of Parkinson's Disease And Amyotrophic Lateral Sclerosis / Martha C. Bohn, Bronwen Connor, Dorothy A. Kozlowski And M. Hasan Mohajeri -- Repair Of Corticospinal Axons By Transplantation Of Olfactory Ensheathing Cells / Geoff Raisman -- Neural Transplantation In Parkinson's Disease / Olle Lindvall --^ Transplantation Of Human Fetal Striatal Tissue In Huntington's Disease : Rationale For Clinical Studies / Thomas B. Freeman, Robert A. Hauser, Alison E. Willing, Tanja Zigova, Paul R. Sanberg And Samuel Saporta -- Neurotransplantation In Neurodegenerative Disease : A Survey Of Relevant Issues In Developmental Neurobiology / Jack Price, Dafe Uwangho, Scott Peters, Diane Galloway And Karen Mellodew -- Molecular And Cellular Mechanisms In Immune Rejection Of Intracerebral Neural Transplants / Thomas Brevig, Erik Bo Pedersen And Bente Finsen -- Porcine Neural Xenografts : What Are The Issues? / Roger A. Barker -- Gene Transfer Techniques For The Delivery Of Gdnf In Parkinson's Disease / Jean-luc Ridet, Nicole Déglon And Patrick Aebischer -- Neurogenesis In The Adult Hippocampus / Gerd Kempermann And Fred H. Gage --^ Neural Stem Cells Are Uniquely Suited For Cell Replacement And Gene Therapy In The Cns / Vaclav Ourednik, Jitka Ourednik, Kook I. Park, Y.d. Teng, Karen A. Aboody, Kurtis I. Auguste, Rosanne M. Taylor, Barbara A. Tate And Evan Y. Snyder -- Functional Repair With Neural Stem Cells / John D. Sinden, Paul Stroemer, Gregory Grigoryan, Sara Patel, Sarah J. French And Helen Hodges -- Remyelinating The Demyelinated Cns / W.f. Blakemore, P.m. Smith And R.j.m. Franklin. Symposium On Neural Transplantation And Neurodegenerative Disease: Current Status And New Directions, Held At The Novartis Foundation, London, 12-14 October 1999-- P.v. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web.

The field of neural transplantation is at a crucial stage in its development, with results of important clinical trials on transplantation in patients with Parkinson's disease expected soon and novel, alternative approaches to fetal transplantation being actively investigated. This timely book brings together leading neuroscientists, clinicians, and cell and developmenta; biologists to discuss the use of neural transplants in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, such as xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book draws together much new and exciting work in this field, and identifies promising new research directions.

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential a Neural transplantation can be used to treat neurodegenerative diseases through a variety of methods. The field is at a critical stage in its development, particularly in light of ongoing investigations into Parkinson's disease and alternatives to fetal transplantation.