Near-infrared Speckle Contrast Diffuse Correlation Tomography for Noncontact Imaging of Tissue Blood Flow Distribution

"Imaging of tissue blood flow (BF) distributions provides vital information for the diagnosis and therapeutic monitoring of various vascular diseases. The innovative near-infrared speckle contrast diffuse correlation tomography (scDCT) technique produces full 3D BF distributions. Many advanced features are provided over competing technologies including high sampling density, fast data acquisition, noninvasiveness, noncontact, affordability, portability, and translatability across varied subject sizes. The basic principle, instrumentation, and data analysis algorithms are presented in detail. The extensive applications are summarized such as imaging of cerebral BF (CBF) in mice, rat, and piglet animals with skull penetration into deep brain. Clinical human testing results are described by recovery of BF distributions on preterm infants (CBF) through incubator wall, and on sensitive burn tissues and mastectomy skin flaps without direct device-tissue interactions. Supporting activities outlined include integrated capability for acquiring surface curvature information, rapid 2D blood flow mapping, and optimizations via tissue-like phantoms and computer simulations. These applications and activities both highlight and guide the reader as to the expected abilities and limitations of scDCT for adapting into their own preclinical/clinical research, use in constrained environments (i.e., neonatal intensive care unit bedside), and use on vulnerable subjects and measurement sites"-- Provided by publisher Cover Half Title Title Page Copyright Page Table of Contents Acknowledgments or Credits List Authors 1 Introduction Significance of Blood Flow Imaging Technologies for Blood Flow Imaging History of scDCT Development References 2 scDCT Methods Principle Instrumentation Boundary Data Collection Image Reconstruction References 3 scDCT Validations and Applications Testing and Validating in Standard Phantoms and Computer Simulations Proof-of-Concept Validation Full Noncontact Validation and Optimal SD Separations for Larger ROI Optimal SD Separations When Using Iris Diaphragm for Smaller ROI Optimal SD Separations Using sCMOS Camera Validation of PST for Arbitrary Surface Geometry Acquisition Validation on Human Infant Skulls Application 1: Imaging of Brains Assessing CBF in a Mouse Assessing CBF in Rats Neonatal Piglet CBF Recovery Noninvasive Monitoring of Human Infant CBF Application 2: Imaging of Burn/Wound Tissues Application 3: Imaging of Mastectomy Skin Flaps Recovery of Blood Flow Distributions during Mastectomy Reconstruction Surgery Incorporating Measured Surface Curvatures by PST Comparing scDCT and FA Imaging Equivalence for Judging Mastectomy Skin Flap Status References 4 Summary and Future Perspectives References Index This book both highlights and guides the reader as to the expected abilities and limitations of scDCT for adapting into their own preclinical/clinical research, use in constrained environments (i.e., neonatal intensive care unit bedside), and use on vulnerable subjects and measurement sites.