Nature (Nature magazine): Vol. 477, No. 7364, pp. 249-364; 2011 September 15
معرفی کتاب «Nature (Nature magazine): Vol. 477, No. 7364, pp. 249-364; 2011 September 15» نوشتهٔ Richard Durbin، Rebecca E. McIntyre، Amarjit Bhomra، Jérôme Nicod، Xiangchao Gan، Wei Yuan، Louise van der Weyden، Charles A. Steward، Sendu Bala، Jim Stalker، Richard Mott، Peter L. Oliver، Ian J. Jackson، Anne Czechanski، José Afonso Guerra-Assunção، Leah Rae Donahue، Laura G. Reinholdt، Bret A. Payseur، Chris P. Ponting، Ewan Birney، Jonathan Flint، Guy Slater، Andrew Edwards، Thomas M. Keane، Leo Goodstadt، Petr Danecek، Michael A. White، Kim Wong، Binnaz Yalcin، Andreas Heger، Avigail Agam، David J. Adams، Martin Goodson، Nicholas A. Furlotte، Eleazar Eskin، Christoffer Nellåker، Helen Whitley، James Cleak، Deborah Janowitz، Polinka Hernandez-Pliego و T. Grant Belgard، منتشرشده توسط نشر Springer Science and Business Media LLC. این کتاب در 20 صفحه، فرمت djvu، زبان انگلیسی ارائه شده است.
We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism.