Natural resistance systems against foreign cells, tumors, and microbes : proceedings of an international conference held at Timber Cove Inn, Jenner, California, October 18-22, 1976

Natural Resistance Systems Against Foreign Cells, Tumors, and Microbes presents the proceedings of an international conference held at Timber Cove Inn Jenner, California on October 18-22, 1976. It deals with the resistance to microorganisms and tumors, the dual problems of basic immunology, and the clinical aspects of immune reconstitution. It focuses on the identification and characterization of host defense systems, endowed with specificity, yet non-induced, non-adaptive, and non-thymus dependent. Divided into 12 chapters, the book initially discusses natural resistance to foreign hematopoietic and leukemic grafts. It goes on, examining the critical issues in clinical bone marrow transplantation and graft-versus-host (GVH) disease as a consequence of bone marrow grafting. Chapters 5 to 8 discuss the role of macrophage, Hh genes, major histocompatibility complex, and natural killer cell systems in natural resistance to normal and malignant cells. The final chapters cover the mechanism of cell's natural resistance to intracellular bacteria, genetic resistance to leukomogenesis, and manipulations to control the allograft response and GVH disease. This book is an invaluable resource for those interested in basic immunology, immune reconstitution, natural resistance phenomena, and GHV disease. Content: Perspectives in Immunology , Page ii Front Matter , Page iii Copyright , Page iv CONFEREES , Pages vii-viii PREFACE , Pages ix-x , Gustavo Cudkowicz, Maurice Landy, Gene M. Shearer ACKNOWLEDGMENTS , Pages xi-xii NATURAL RESISTANCE TO FOREIGN HEMOPOIETIC AND LEUKEMIA GRAFTS , Pages 1,3-30 , Gustavo Cudkowicz THYMIC FUNCTIONS AND RESISTANCE TO FOREIGN HEMOPOIETIC GRAFTS , Pages 31,33-45 , Osias Stutman CRITICAL ISSUES IN CLINICAL BONE MARROW TRANSPLANTATION , Pages 47,49-71 , Rainer Storb GRAFT-VERSUS-HOST DISEASE AS A CONSEQUENCE OF BONE MARROW GRAFTING , Pages 73,75-90 , William L. Elkins MACROPHAGE HETEROGENEITY: ROLE IN HEMOPOIESIS AND CYTOTOXICITY FOR NORMAL AND NEOPLASTIC TARGETS , Pages 91,93-112 , Malcolm A.S. Moore IN VITRO MODELS OF Hh-MEDIATED RESISTANCE AND MHC INCOMPATIBILITY , Pages 113,115-142 , Fritz H. Bach MHC-RESTRICTED CELLULAR IMMUNITY: ALTERED SELF AND MINOR ALLOANTIGENS , Pages 143,145-172 , Gene M. Shearer NK CELL SYSTEMS AS EFFECTORS OF RESISTANCE TO NORMAL AND MALIGNANT HEMOPOIETIC CELLS , Pages 173,175-196 , Hans Wigzell DISTINCTIVE MECHANISMS IN NATURALLY OCCURRING GENETIC RESISTANCE TO LEUKEMOGENESIS , Pages 197,199-232 , Richard A. Steeves MECHANISM OF NATURAL RESISTANCE TO INTRACELLULAR BACTERIA. MANIPULATIONS WEAKENING RESISTANCE SYSTEMS , Pages 233,235-247 , Michael Bennett MANIPULATIONS TO CONTROL THE ALLOGRAFT RESPONSE AND GVH DISEASE , Pages 249,251-269 , Harvey Cantor CONFERENCE OVERVIEW AND ASSESSMENT , Pages 271,273-289 , Donald Metcalf, Jonathan W. Uhr ABBREVIATIONS , Pages 291-292 AUTHOR INDEX , Pages 293-294 SUBJECT INDEX , Pages 295-299