NATURAL PRODUCTS AND THEIR BIOACTIVES IN ANTIDIABE TIC DRUG DISCOVERY

Natural Products and their Bioactives in Antidiabetic Drug Discovery Enables researchers to effectively understand and use bioactive compounds to target, prevent, and manage diabetes Natural Products and Their Bioactives in Antidiabetic Drug Discovery provides readers with an overview of recent research in new drug discovery against diabetic complications based on bioactives from NPs, bridging the gap between the public research institutes and private companies working to find drugs to treat diabetes. To aid in reader comprehension, the text includes case studies and illustrated examples in relevant chapters. Part one presents chapters on fundamental concepts of diabetes mellitus (DM) and recent drug discovery progress along with the various druggable targets and challenges. Part two covers bioactive compounds targeting Type-1 Diabetes. Part three focuses on Type-2 Diabetes. In Part four, the contributors address gestational DM prevention and management with natural compounds. Written by a global team of experts in the field, Natural Products and their Bioactives in Antidiabetic Drug Discovery covers sample topics such as: Obesity risk factor in patients with T1DM and possible role of nutritional therapy in its management Use of natural non-insulin drugs as a novel approach to enhance therapeutic outcomes against T1DM Effectiveness of functional foods in intervening the diabetic complications and realistic results in clinical trials Implementation of nanotechnology in improving the bioavailability and reducing the threshold dose of bioactive compounds Various antidiabetic mechanisms of action of different polyphenols and immunomodulatory role of NPs bioactives relevance in T1DM therapy Effects of natural products on genetics of gestational diabetes With comprehensive coverage of recent research in new drug discovery against diabetic complications based on bioactives from NPs, Natural Products and Their Bioactives in Antidiabetic Drug Discovery is an essential resource for researchers and professionals involved in drug discovery and development, health care, medicinal chemistry, phytochemistry, plant science, and toxicology. Natural Products and their Bioactives in Antidiabetic Drug Discovery Contents List of Contributors Preface Part I Fundamental Concepts of Diabetes Mellitus and Drug Discovery Process 1 Diabetes Mellitus and Natural Product-based Drug Discovery: Novel Directions 2 Marine Natural Products in the Management of Diabetes Mellitus 3 Carbohydrate-based Antidiabetic Agents from Natural Products 4 Functional Foods in Clinical Trials in the Intervention of Diabetes Complications 5 Role of Nanotechnology in Refining the Antidiabetic Activities of Plant Derived Bioactives Part II Bioactive Compounds Against Type 1 Diabetes Mellitus 6 Epidemiology and Genetics of Type 1 Diabetes Mellitus: The Effect of the Mediterranean Diet 7 The Emerging Role of Plant Polyphenols in the Management of Type 1 Diabetes Mellitus 8 Bioactives as Modulators of β-cells and Immunity in Therapy of Type 1 Diabetes Mellitus 9 Obesity in Type 1 Diabetes Mellitus: Clinical Impact and Nutritional Therapy 10 Protective Effects of Natural Non-insulin Drugs against Type 1 Diabetes Mellitus Part III Bioactive Compounds Against Type 2 Diabetes Mellitus 11 Age-induced Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus: Role of Plant Polyphenols 12 Bioactives from Clove Oil for Antibacterial Wound Dressings for the Treatment and Management of Wounds in Type 2 Diabetes Mellitus 13 Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus 14 Effect of Resveratrol and Catechins in Maintaining Redox Homeostasis during Type 2 Diabetes Mellitus 15 Cannabis: Action Mechanisms and Potential Roles in the Management of Type 2 Diabetes Mellitus Part IV Gestational Diabetes: Prevention and Management by Natural Compounds 16 Epidemiology of Gestational Diabetes Mellitus: Preventive Significance of Dietary Pattern 17 Biomarkers of Gestational Diabetes Mellitus, Dietary Polyphenols, and Drug Discovery 18 Medicinal and Aromatic Plants in the Prevention of Gestational Diabetes and Associated Consequences: Current Insights 19 Enhancement of Insulin Sensitivity and Management of Lipid Disorders during Gestational Diabetes Mellitus: Role of Capsaicin 20 Effects of Natural Products on the Genetics of Gestational Diabetes Mellitus Index EULA