Natural and induced cell-mediated cytotoxicity : effector and regulatory mechanisms : proceedings of the Erwin Riesch Symposium, organized on the occasion of the fifth centennial of the University of Tübingen at Weitenburg bei Tübingen, Germany, October

First printing. Hardcover. DJ in new mylar. 6 x 9. 242 pages. Illustrated with graphs Content: Perspectives in Immunology, Page ii Front Matter, Page iii Copyright, Page iv CONFEREES, Pages ix-x PREFACE, Pages xi-xii, G. RIETHMÜLLER, P. WERNET, G. CUDKOWICZ ACKNOWLEDGMENTS, Page xiii CHARACTERISTICS OF NATURAL CYTOTOXIC CELLS IN MICE, Pages 1-5, Rolf Kiessling GENERATION IN VIVO OF MOUSE NATURAL CYTOTOXIC CELLS, Pages 7-17, Otto Haller ARE CYTOTOXIC T CELLS RELEVANT IN THE LOCAL DEFENSE AGAINST SOLID TUMORS?, Pages 19-27, Stephen Haskill, Susanne Becker NATURAL CYTOTOXICITY OF HUMAN LYMPHOCYTES. IMMUNOGLOBULIN DEPENDENT AND INDEPENDENT SYSTEMS, Pages 29-36, P. Perlmann, M. Troye, G.R. Pape, B. Harfast, T. Andersson CHARACTERIZATION OF EFFECTOR CELLS IN HUMAN NATURAL CYTOTOXICITY, Pages 37-42, Gerd R. Pape, Marita Troye, Peter Perlmann EFFECTOR CELLS OF NATURAL CYTOTOXICITY AGAINST HUMAN MELANOMA CELLS, Pages 43-55, E.P. Rieber, J.G. Saal, M. Hadam, G. Riethmüller, H. Rodt, M.P. Dierich RELATION OF EFFECTOR MECHANISMS TO TARGET CELL ORIGIN, Pages 57-62, M. Troye, G.R. Pape, M. Vilien, P. Perlmann MODELS FOR MECHANISMS OF NATURAL CYTOTOXICITY, Pages 63-73, Guy D. Bonnard, H. David Kay, Ronald B. Herberman, John R. Ortaldo, Julie Djeu, Kathy J. Pfiffner, J. Ronald Oehler OPPOSING EFFECTS OF INTERFERON ON NATURAL KILLER AND TARGET CELLS, Pages 75-81, Giorgio Trinchieri, Daniela Santoli SPECIFICITY OF NATURAL CYTOTOXIC CELLS DETERMINED BY ANTIBODY, Pages 83-88, Mitsuo Takasugi, Donna Akira MANIPULATIONS OF NATURAL CYTOTOXICITY IN TUMOR PATIENTS VIA BCG, Pages 89-98, Johannes G. Saal, Gert Riethmüller, Martin R. Hadam, Ernst P. Rieber, Joachim M. Fleiner SUSCEPTIBILITY OF CLONED MELANOMA TO NATURALCYTOTOXICITY, Pages 99-115, I. Korn-Nitschmann, H.H. Peter, E. Krapf, E. Krmpotic, L. Krmpotic, J.P. Cesarini, W. Leibold ANTIGEN RECOGNITION BY CYTOTOXIC T LYMPHOCYTES, Pages 117-128, Kirsten Fischer-Lindahl GENERATION OF TNP-SPECIFIC H-2-RESTRICTED MURINE CYTOTOXIC CELLS AS A FUNCTION OF TNP-CELL SURFACE PRESENTATION, Pages 129-133, Carla B. Pettinelli, Anne-Marie Schmitt-Verhulst, Gene M. Shearer SECONDARY SENDAI-SPECIFIC T-EFFECTOR CELLS: REQUIREMENTS FOR RESTIMULATION, TARGET CELLS RECOGNITION, AND LYSIS, Pages 135-144, Ulrich Koszinowski, Mary Jane Gething, Evan T. Smith, Michael Waterfield CYTOTOXIC T LYMPHOCYTES INDUCED BY H-2 NEGATIVE STIMULATOR CELLS, Pages 145-149, Hermann Wagner, Martin Röllinghoff, Pierre Golstein CELL MEDIATED IMMUNITY AGAINST AVIAN VIRUS-INDUCED TUMOR CELLS, Pages 151-155, Masanori Hayami, Jagodina Ignjatovich, Bernhard Fleischer, Johannes F. Steffen, Helga Rübsamen, Heinz Bauer ALTERNATIVE ROUTES OF ENTRY FOR CELL SURFACE ANTIGENS INTO THE IMMUNE SYSTEM, Pages 157-163, E. Clark, P. Lake, N.A. Mitchison, I. Nakashima CELL-MEDIATED CYTOTOXICITY AGAINST TNP-MODIFIED HUMAN LEUKOCYTES, Pages 165-175, Stephen Shaw, Gene M. Shearer HLA RESTRICTION OF CYTOTOXICITY AGAINST INFLUENZA-INFECTED HUMAN CELLS, Pages 177-181, A.J. McMichael SELF-RESTRICTED CYTOTOXICITY AGAINST ACUTE MYELOID LEUKEMIA CELLS, Pages 183-189, R.T.D. Oliver, S.K. Lee REGULATORY ROLE OF MACROPHAGES IN NORMAL AND NEOPLASTIC HEMOPOIESIS, Pages 191-198, Malcolm A.S. Moore, Jeffrey I. Kurland SERUM HEMATOPOIETIC INHIBITORS AND TUMOR NECROSIS FACTOR, Pages 199-207, M.A.S. Moore, R. Shah, S. Green ROLE OF ADHERENT CELLS IN THE INDUCTION OF CYTOTOXIC T LYMPHOCYTES: PROMOTION, SUPPRESSION, AND ANTIGEN PRESENTATION, Pages 209-220, Gustavo Cudkowicz, Yee Pang Yung, William W. Freimuth CYTOTOXICITY OF BONE MARROW MACROPHAGES FOR NORMAL AND MALIGNANT TARGETS, Pages 221-226, Marie Louise, Lohmann Matthes INTERFERON INDUCTION BY CORYNEBACTERIUM PARVUM, Pages 227-232, H. Kirchner, H.M. Hirt, K. Munk RECAPITULATION AND ASSESSMENT OF THE CONFERENCE DISCUSSIONS, Pages 233-242, Gert Riethmüller, Gustavo Cudkowicz, Maurice Landy Natural and Induced Cell-Mediated Cytotoxicity: Effector and Regulatory Mechanisms contains the proceedings of the Erwin Riesch Symposium organized on the occasion of the Fifth Centennial of the University of Tübingen in Germany on October 20-23, 1977. The symposium provided a forum for reviewing the progress that has been made in understanding the effector and regulatory mechanisms underlying natural and induced cell-mediated cytotoxicity. Topics covered range from the immunobiology of natural killer cells to the role of macrophages as regulator, accessory, and effector cells in cytotoxicity. Comprised of 27 chapters, this book begins by analyzing the characteristics of natural cytotoxic cells in mice, followed by a discussion on the generation in vivo of mouse natural cytotoxic cells and the role of cytotoxic T cells in the local defense against solid tumors. Subsequent chapters focus on the natural cytotoxicity of human lymphocytes; opposing effects of interferon on natural killer and target cells; susceptibility of cloned melanoma to natural cytotoxicity; and cell-mediated immunity against avian virus-induced tumor cells. The book also examines alternative routes of entry for cell surface antigens into the immune system before concluding with a chapter that considers interferon induction by Corynebacterium parvum. This monograph should be of value to students, researchers, and practitioners in the fields of biology and immunology.