National Institute of Allergy and Infectious Diseases, NIH : Volume 3: Intramural Research

Front Matter....Pages i-xix Front Matter....Pages 1-1 The Evolution of Gammaretrovirus Restriction Factors in the Mouse....Pages 3-11 Herpesvirus Research at the National Institute of Allergy and Infectious Diseases: Thirty Years of Progress....Pages 13-25 Why Study Mouse Retroviruses?....Pages 27-30 Functions of the Rotavirus RNA Polymerase in Virus Replication....Pages 31-40 Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T-Cell Leukemia....Pages 41-49 Front Matter....Pages 51-51 Roles for Chemokine Receptors in HIV Pathogenesis....Pages 53-57 HIV-1 Accessory Proteins: Crucial Elements for Virus-Host Interactions....Pages 59-71 Front Matter....Pages 73-73 Exploring the Cause of Human Q Fever: Recent Advances in Coxiella burnetii Research....Pages 75-85 Plague in the 21st Century: Global Public Health Challenges and Goals....Pages 87-94 Molecular Biology of Staphylococcal Pathogenesis....Pages 95-99 Investigations of Relapsing Fever at Home and Abroad....Pages 101-106 Molecular Sleuthing with the Lyme Disease Agent....Pages 107-115 Modeling of Acute Respiratory Melioidosis and Glanders....Pages 117-120 Front Matter....Pages 121-121 Cryptococcosis: From Discovering the Natural Reservoir of its Etiology to the Genetic Manipulation of Cryptococcus neoformans : Milestones in Cryptococcal Research by Intramural Investigators at NIAID....Pages 123-134 Front Matter....Pages 135-135 Lessons from Parasites on CD4 + T-Cell Subset Differentiation and Function....Pages 137-142 Molecular Aspects of Parasite – Vector Interactions In Leishmaniasis....Pages 143-149 Front Matter....Pages 151-151 Mosquito Strategies Against Plasmodium : A Tale of Restrained Response and Immune Evasion....Pages 153-159 The Plasmodial Surface Anion Channel: A Model Microbial Ion Channel and Target for Antimalarial Drug Development....Pages 161-167 Genomics and Genetics of Drug Resistance and Regulation of Malaria Parasite Development....Pages 169-175 Front Matter....Pages 177-177 Modulation of Human Dendritic Cells by Highly Virulent Pathogens....Pages 179-183 Front Matter....Pages 177-177 Making Friends in Out-of-the- Way Places: How Cells of the Immune System Get Together and How They Conduct Their Business as Revealed by Intravital Imaging....Pages 185-202 Role of Regulatory/Suppressor T Cells in Immune Responses....Pages 203-213 Proliferation versus Contraction of Immune Cells, the Non-Apoptotic Role of Caspase 8 In Immune Homeostasis....Pages 215-220 Features of Plasma Cell-Related Neoplasms in Mice....Pages 221-230 A Role of IRF8 in Transcriptional Control of B-Cell Development....Pages 231-241 Laboratory of Molecular Immunology....Pages 243-247 Front Matter....Pages 249-249 Structure and Function of Immunoreceptors....Pages 251-259 Role of the NKG2D Receptor in Health and Disease....Pages 261-273 Front Matter....Pages 275-275 G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease....Pages 277-281 Mast Cell Precursors and Signaling Pathways....Pages 283-295 Front Matter....Pages 297-297 Prion Biochemistry and Therapeutics....Pages 299-303 Neutrophils in the Resolution of Infection....Pages 305-310 Reactive Oxidant-Dependent Innate Immune Defenses of the Airway Epithelium: The Dual Oxidase-Lactoperoxidase-Thiocyanate System....Pages 311-318 Chronic Granulomatous Disease: From Lethal Pediatric Mystery to Complex Chronic Disease....Pages 319-352 Pneumonia Virus of Mice (PVM): Exploring Novel Therapeutic Options In a Severe Respiratory Disease Model....Pages 353-359 The 1918 Influenza Pandemic: Pathology and Pathogenesis....Pages 361-368 Front Matter....Pages 369-369 Mind Your Xs and Ys: Genetics of the Autoimmune Disease Systemic Lupus Erythematosus....Pages 371-376 A Bench-to-Bedside Trail of Research Leading to the Understanding and Treatment of Ulcerative Colitis....Pages 377-383 Front Matter....Pages 385-385 Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses....Pages 387-402 How Do You Say “B-Cell Biology” In “Vaccinology”: Translational Research In the NIAID....Pages 403-407 Front Matter....Pages 385-385 Malaria Vaccine Development....Pages 409-422 The Development of Live-Attenuated Vaccines for Pandemic Influenza....Pages 423-430 Targeting the Messenger: Vector-Based Vaccines to Control Leishmania Infection and Transmission....Pages 431-436 Back Matter....Pages 437-449 National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields of biomedical research. This volume focuses on individual research contributions by internationally known scientists doing research in the NIAID laboratories. National Institute of Allergyand Infectious Diseases, NIH 4 Foreword 6 Contents 8 Contributors 12 Part I: Microbiology: Virology 22 Part II:IMicrobiology: Human Immunodeficiency Virus (Hiv) 68 Part III:Microbiology: Bacteriology 87 Part IV:Microbiology: Mycology 131 Part V:Microbiology: Parasitology 144 Part VI:Microbiology: Malaria 158 Part VII:Immunology: Cellular Immunology 180 Part VIII:mmunology: The Role of Receptors 247 Part IX:Allergy 270 Part X:Clinical Medicine: Infectious Diseases 289 Part XI:Clinical Medicine: Autoimmune Diseases 358 Part XII:Clinical Medicine: Vaccines 372 Index 422 For over 50 years, the mission of the National Institute of Allergy and Infectious Diseases (NIAID) has been to conduct and support basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases with the ultimate goal of improving the health of individuals in the United States and around the world. As part of its mission to foster biomedical discovery and to reduce the burden of human disease, NIAID is committed to encouraging the accelerated translation of biomedical discoveries into effective clinical care and public health practice through