Nasopharyngeal carcinoma : keys for translational medicine and biology

This volume intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the 12 chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis and various aspects of host-tumor interactions. Front Matter....Pages i-xix Diagnosis and Clinical Evaluation of Nasopharyngeal Carcinoma....Pages 1-9 Histopathological Diagnosis of Nasopharyngeal Carcinoma: Looking beyond the Blue Book....Pages 10-22 Descriptive, Environmental and Genetic Epidemiology of Nasopharyngeal Carcinoma....Pages 23-41 Epstein-Barr Virus and the Pathogenesis of Nasopharyngeal Carcinomas....Pages 42-60 Acquired Genetic and Epigenetic Alterations in Nasopharyngeal Carcinoma....Pages 61-81 Cellular Interactions in Nasopharyngeal Carcinomas....Pages 82-100 Biological Tools for NPC Population Screening and Disease Monitoring....Pages 101-117 Medical Imaging of Nasopharyngeal Carcinomas: Current Tools and Applications....Pages 118-124 Radiotherapy of NPC: Current Strategies and Perspectives....Pages 125-148 The Evolving Role of Systemic Therapy in Nasopharyngeal Carcinoma: Current Strategies and Perspectives....Pages 149-172 Nasopharyngeal Carcinoma Immunotherapy: Current Strategies and Perspectives....Pages 173-186 Therapeutic Induction of Apoptosis in Nasopharyngeal Carcinoma....Pages 187-199 Back Matter....Pages 201-205