Nanotechnology for Biology and Medicine: At the Building Block Level (Fundamental Biomedical Technologies)

Annotation This text book will bring together a mix of both internationally known and established senior scientists along side up and coming but already accomplished junior scientists that have varying expertise in fundamental and applied nanotechnology to biology and medicine Nanotechnology for Biology and Medicine: At the Building Block Level℗¡introduces the reader to current cutting-edge approaches being pursued for the design and development of nanotechnology applications to different areas of biology and medicine. It discusses the key biological challenges at the molecular and cellular levels being faced by this new field, and some of the strategies being developed to address them. The specific topics covered include the extracellular environment and design of engineered matrices, synthetic patterning methods for biological applications, molecular motors and machines, atomic force microscopy methods for measuring nanoscale features, and the use of quantum dot and carbon nanotube nanotechnologies for imaging and interfacing with neural cells. It is intended to serve as an introduction to the field, while providing in-depth coverage for the more advanced reader. ℗¡ Gabriel A. Silva, MSc, PhD is the Jacobs Faculty Fellows Professor of Bioengineering and an Associate Professor in the Departments of Bioengineering and Ophthalmology at the University of California, San Diego. He also is co-director of the Retina Engineering Center in the Institute of Engineering in Medicine. He is an affiliated faculty member in the Department of NanoEngineering, and a member of the Neurosciences Graduate Program, Computational Neurobiology Program, and Institute for Neural Computation. He received his Hon. B. Sc. and M. Sc. from the University of Toronto in 1996 and 1997, and a Ph. D. from the University of Illinois at Chicago in 2001. Dr. Silva completed a postdoc at Northwestern University in Chicago from 2001 to 2003,℗¡and ℗¡joined the faculty at the University of California, San Diego in 2004. Vladimir Parpura, MD, PhD holds both a medical degree, awarded from the University of Zagreb in Croatia in 1989, and a doctorate, received in Neuroscience and Zoology from Iowa State University in 1993.℗¡ He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University and the Department of Cell Biology and Neuroscience, University of California Riverside. He is presently an Associate Professor in the Department of Neurobiology, University of Alabama Birmingham.℗¡ Nanotechnology for Biology and Medicine: At the Building Block Level introduces the reader to current cutting-edge approaches being pursued for the design and development of nanotechnology applications to different areas of biology and medicine. It discusses the key biological challenges at the molecular and cellular levels being faced by this new field, and some of the strategies being developed to address them. The specific topics covered include the extracellular environment and design of engineered matrices, synthetic patterning methods for biological applications, molecular motors and machines, atomic force microscopy methods for measuring nanoscale features, and the use of quantum dot and carbon nanotube nanotechnologies for imaging and interfacing with neural cells. It is intended to serve as an introduction to the field, while providing in-depth coverage for the more advanced reader. Gabriel A. Silva, MSc, PhD is the Jacobs Faculty Fellows Professor of Bioengineering and an Associate Professor in the Departments of Bioengineering and Ophthalmology at the University of California, San Diego. He also is co-director of the Retina Engineering Center in the Institute of Engineering in Medicine. He is an affiliated faculty member in the Department of NanoEngineering, and a member of the Neurosciences Graduate Program, Computational Neurobiology Program, and Institute for Neural Computation. He received his Hon.B.Sc. and M.Sc. from the University of Toronto in 1996 and 1997, and a Ph.D. from the University of Illinois at Chicago in 2001. Dr. Silva completed a postdoc at Northwestern University in Chicago from 2001 to 2003, and joined the faculty at the University of California, San Diego in 2004. Vladimir Parpura, MD, PhD holds both a medical degree, awarded from the University of Zagreb in Croatia in 1989, and a doctorate, received in Neuroscience and Zoology from Iowa State University in 1993. He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University and the Department of Cell Biology and Neuroscience, University of California Riverside. He is presently an Associate Professor in the Department of Neurobiology, University of Alabama Birmingham. Front Matter....Pages i-xvi Front Matter....Pages 1-1 Structure and Biology of the Cellular Environment: The Extracellular Matrix....Pages 3-23 Front Matter....Pages 25-25 Synthesis and Patterning Methods for Nanostructures Useful for Biological Applications....Pages 27-44 Characterization of Nanoscale Biological Systems: Multimodal Atomic Force Microscopy for Nanoimaging, Nanomechanics, and Biomolecular Interactions....Pages 45-68 Front Matter....Pages 69-69 Molecular Motors and Machines....Pages 71-100 Micro and Nano Engineered Extracellular Matrices....Pages 101-121 Designer Self-Assembling Peptide Nanofiber Scaffolds....Pages 123-147 Front Matter....Pages 149-149 Quantum Dot Imaging of Neural Cells and Tissue....Pages 151-168 Quantum Dot Methods for Cellular Neuroimaging....Pages 169-186 Carbon Nanotubes as Electrical Interfaces to Neurons....Pages 187-207 Carbon Nanotubes as Modulators of Neuronal Growth....Pages 209-223 Back Matter....Pages 225-234