Nanoparticles in the Lung : Environmental Exposure and Drug Delivery / Gehr, Peter

Introduction Akira Tsuda and Peter Gehr Deposition Akira Tsuda and Frank S. Henry Airway/alveolar surface Interaction of nanoparticles with the lung surface Peter Gehr and Akira Tsuda Nanoparticle-interactions with lung fluids: role of the biomolecule corona in nanoparticle fate and behaviour following inhalation Iseult Lynch Interaction of nanoparticles with alveolar lining fluid Vincent Castranova, Dale W. Porter, and Robert R. Mercer Interactions of nanoparticles with lung macrophages Barry Weinberger, Patrick J. Sinko, Jeffrey D. Laskin, and Debra L. Laskin Crossing epithelial cells - interaction between NPs and alveolar epithelium Interactions between nanoparticles and alveolar epithelium Farnoosh Fazllolahi, Yong Ho Kim, Arnold Sipos, Zea Borok, Kwang-Jin Kim, and Edward D. Crandall Some mechanistic aspects of cellular uptake of nanoparticles Lennart Treuel, Xiue Jiang, and Gerd Ulrich Nienhaus Cellular uptake and intracellular trafficking of nanoparticles Barbara Rothen-Rutishauser, Dagmar A. Kuhn, Dimitri Vanhecke, Fabian Herzog, Alke Petri-Fink, and Martin JD Clift Translocation Translocation across the air-blood tissue barrier Fabian Blank, Christophe von Garnier, Peter Gehr, and Barbara Rothen-Rutishauser Nanoparticles and the pulmonary lymphatic system Akira Tsuda Translocation and accumulation of inhaled nanoparticles in the body Wolfgang G. Kreyling Nanoparticle drug delivery to respiratory tract Practical considerations for nanoparticle drug delivery to the respiratory tract John S. Patton Polyplex nanomicelles for drug and gene delivery toward the lungs Satoshi Uchida, Keiji Itaka, and Kazunori Kataoka Bio-nanocapsules: nanocarriers harboring virus-derived infection machinery for use as pinpoint drug delivery systems Shun'ichi Kuroda Special issues about nanoparticles Physicochemical, colloidal and transport properties of nanoparticles Heinrich Hofmann, Lionel Maurizi, Marie-Gabrielle Beuzelin, Usawadee Sakulkhu and Vianney Bernau Towards accurate and relevant dosimetry for In vitro nanotoxicology Joel M. Cohen and Philip Demokritou The potential of nanoparticles for nose-to-brain delivery of drugs Lisbeth Illum Nanoparticles in the developing lungs Akira Tsuda and Frank S. Henry Nanotoxicology Dominique Balharry, Eva Gubbins, Helinor Johnston, Ali Kermanizadeh, and Vicki Stone Summary Peter Gehr and Akira Tsuda "Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding of how inhaled nanoparticles behave in the human lungs and body. Featuring contributions from renowned subject-matter experts, this authoritative text describes the sequence of events that nanoparticles encounter in the lungs when moving from the air into the bloodstream. This includes deposition, interactions with the alveolar surface and epithelium, translocation across the air©Ø℗ђ℗أblood tissue barrier, and accumulation in the body. In addition, the book addresses practical considerations for drug delivery to the respiratory tract, drug and gene delivery in the lungs, and bio-nanocapsules. It considers the physicochemical, colloidal, and transport properties of nanoparticles, and presents cutting-edge research on special issues such as dosimetry for in vitro nanotoxicology, nanoparticle deposition in the developing lungs, and the potential for nose-to-brain delivery of drugs.Nanoparticles in the Lung: Environmental Exposure and Drug Delivery offers the most updated and comprehensive knowledge of the risks and benefits associated with nanoparticle inhalation©Ø℗ђ℗ؤto protect humans from any harmful effects and to explore the utility of nanoparticles as drug delivery carriers."--Provided by publisher Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger e.g., micrometer particles, are considered to behave differently when they interact with cells. The book describes the sequence of events that airborne nanoparticles encounter in the lungs when they move from air to the bloodstream. This includes deposition, events occurring on the alveolar surface (inc!. retention and clearance, interaction with surfactant and with alveolar lining fluid), crossing the air-blood tissue barrier, and finally get Section 1. Gas Phase -- Section 2. Airway/alveolar Surface -- Section 3. Crossing Epithelial Cells -- Section 4. Translocation -- Section 5. Drug Delivery To The Respiratory Tract -- Section 6. Special Issues. Edited By Akira Tsuda, Harvard University, Cambridge Massachusetts, Usa, Peter Gehr, University Of Bern, Switzerland. Includes Bibliographical References And Index. Also Available In Electronic Format.