Myoclonic Epilepsies: Understanding Its Nature, Diagnosis and Treatment (Advances in Neurology)

This volume is the first comprehensive text and clinical reference on idiopathic myoclonic epilepsies of infancy, childhood, adolescence, and adulthood. The world’s foremost experts describe the phenotypes and subtypes of myoclonic epilepsies and the underlying molecular defects and summarize cutting-edge advances in molecular genetics that shed new light on the etiologies of these syndromes. The book offers clinicians much-needed assistance in recognizing and diagnosing idiopathic myoclonic epilepsies and selecting appropriate treatment. Each chapter includes diagnostic and treatment algorithms to guide practitioners in clinical decision making. This Volume Covers Idiopathic Myoclonic Epilepsies, Including Seizures, Syndromes, And The Definition Of Molecular Etiologies Of Specific Epilepsies That Define Them As Diseases. The Book Is Thus Designed To Help The Practitioner Recognize And Understand The Phenotypes And Subtypes Of Myoclonic Epilepsies Which Account For At Least 25% To 30% Of All Epilepsies, As Well As The Molecular Defects Underlying Myoclonic Epilepsies. While This Volume Incorporates Molecular Advances, It Remains A Practical Guide For Practitioner By Using Diagnostic/treatment Algorithms To Demonstrate The Decision Process Involved In Diagnosis And Treatment Of Idiopathic Epilepsies Including: Severe Myoclonic Epilepsy Of Infancy, Generalized Epilepsies With Febrile Seizures, Myoclonic Astatic Epilepsy Of Early Childhood, Juvenile Myoclonic Epilepsy, Childhood Absence Evolving To Juvenile Myoclonic Epilepsy, Familial Adult Myoclonic Epilepsy And Benign Myoclonic Epilepsy Of Infancy. As The First And Only Collation Of All That Is Known About Idiopathic Myoclonic Epilepsies This Book Should Be An Indispensable Resource For All Practitioners Dealing With Epilepsy.--book Jacket. History And Classification Of Myoclonic Epilepsies: From Seizures To Syndromes To Diseases / Pierre Genton ... [et Al.] -- Ontogeny Of The Reticular Formation: Its Possible Relation To The Myoclonic Epilepsies / Harvey B. Sarnat -- Pathophysiology Of Myoclonic Epilepsies / Renzo Guerrini ... [et Al.] -- Progressive Myoclonus Epilepsies: Epm1, Epm2a, Epm2b / Elayne M. Chan -- Myoclonic Status In Non-progressive Encephalopathies / Bernardo Dalla Bernardina -- Severe Myoclonic Epilepsy In Infancy: Dravet Syndrome / Charlotte Dravet ... [et Al.]. Severe Myoclonic Epilepsy In Infancy: Clinical Analysis And Relation To Scn1a Mutations In A Japanese Cohort / Hirokazu Oguni ... [et Al.] -- Myoclonic Seizures In The Context Of Generalized Epilepsy With Febrile Seizures Plus (gefs+) / Michel Baulac ... [et Al.] -- Benign Myoclonic Epilepsy In Infancy / Charlotte Dravet And Michelle Bureau -- Autosomal Recessive Benign Myoclonic Epilepsy Of Infancy / Federico Zara And Fabrizio A. De Falco -- Myoclonic-astatic Epilepsy Of Early Childhood-definition, Course, Nosography, Genetics / B.a. Neubauer ... [et Al.]. Idiopathic Myoclonic-astatic Epilepsy Of Early Childhood-nosology Based On Electrophysiological And Long-term Follow-up Study Of Patients / Hirokazu Oguni ... [et Al.] -- Myoclonic Absences: The Seizure And The Syndrome / Michelle Bureau And Carlo Alberto Tassinari -- Eyelid Myoclonia And Absence / Athanasios Covanis -- Childhood Absence Epilepsy Evolving To Juvenile Myoclonic Epilepsy: Electroclinical And Genetic Features / Marco T. Medina ... [et Al.] -- Photosensitivity: Genetics And Clinical Significance / B.a. Neubauer ... [et Al.] -- Familial Juvenile Myoclonic Epilepsy / Maria Elisa Alonso ... [et Al.]. Genetics Of Juvenile Myoclonic Epilepsy: Faulty Components And Faulty Wiring? / Martina Durner, Deb Pal, And David Greenberg -- Autosomal Dominant Juvenile Myoclonic Epilepsy And Gabra1 / Patrick Cossette ... [et Al.] -- Clcn2 And Idiopathic Generalized Epilepsy / Armin Heils -- Autosomal Dominant Cortical Myoclonus And Epilepsy (adcme) With Linkage To Chromosome 2p11.1-q12.2 / Renzo Guerrini ... [et Al.] -- Familial Adult Myoclonic Epilepsy (fame) / Eiichiro Uyama, Ying-hui Fu, And Louis J. Ptácek -- Treatment Of Myoclonic Epilepsies In Infancy And Early Childhood / Raman Sankar ... [et Al.]. Ketogenic Diet In Patients With Dravet Syndrome And Myoclonic Epilepsies In Infancy And Early Childhood / Natalio Fejerman, Roberto Caraballo, And Ricardo Cersosimo -- Treatment Of Myoclonic Epilepsies Of Childhood, Adolescence, And Adulthood / Marco T. Medina ... [et Al.]. Editors, Antonio V. Delgado-escueta ... [et Al.]. Includes Bibliographical References And Index. Content: Cover Copyright Editeds Editors Advances in Neurology Series Charlotte Dravet Preface Foreword Acknowledgments Contents Section 1 Introduction to Concepts and Classifications 1 History and Classification of "Myoclonic" Epilepsies: From Seizures to Syndromes to Diseases 2 Ontogeny of the Reticular Formation: Its Possible Relation to the Myoclonic Epilepsies 3 Pathophysiology of Myoclonic Epilepsies 4 Progressive Myoclonus Epilepsies: EPM1, EPM2A, EPM2B 5 Myoclonic Status in Nonprogressive Encephalopathies Section 2 Myoclonic Epilepsies of Infancy and Childhood 6 Severe Myoclonic Epilepsy in Infancy: Dravet Syndrome7 Severe Myoclonic Epilepsy in Infancy: Clinical Analysis and Relation to SCN1A Mutations in a Japanese Cohort 8 Myoclonic Seizures in the Context of Generalized Epilepsy with Febrile Seizures Plus (GEFS+) 9 Benign Myoclonic Epilepsy in Infancy 10 Autosomal Recessive Benign Myoclonic Epilepsy of Infancy 11 Myoclonic-Astatic Epilepsy of Early Childhood -- Definition, Course, Nosography, and Genetics 12 Idiopathic Myoclonic-Astatic Epilepsy of Early Childhood-Nosology Based on Electrophysiologic and Long-Term Follow-Up Study of Patients13 Myoclonic Absences: The Seizure and The Syndrome 14 Eyelid Myoclonia and Absence 15 Childhood Absence Epilepsy Evolving to Juvenile Myoclonic Epilepsy: Electroclinical and Genetic Features 16 Photosensitivity: Genetics and Clinical Significance Section 3 Myoclonic Epilepsies of Adolescence and Adulthood 17 Familial Juvenile Myoclonic Epilepsy 18 Genetics of Juvenile Myoclonic Epilepsy: Faulty Components and Faulty Wiring? 19 Autosomal Dominant Juvenile Myoclonic Epilepsy and GABRA120 CLCN2 and Idiopathic Generalized Epilepsy 21 Autosomal Dominant Cortical Myoclonus and Epilepsy (ADCME) with Linkage to Chromosome 2p11.1-q12.2 22 Familial Adult Myoclonic Epilepsy (FAME) Section 4 Treatment of Myoclonic Epilepsies 23 Treatment of Myoclonic Epilepsies in Infancy and Early Childhood 24 Ketogenic Diet in Patients with Dravet Syndrome and Myoclonic Epilepsies in Infancy and Early Childhood 25 Treatment of Myoclonic Epilepsies of Childhood, Adolescence, and Adulthood