Myocardial Failure: International Symposium, Rottach-egern/tegernsee, Germany, June 17-19, 1976 (international Boehringer Mannheim Symposia)

More than 10 years have passed since the memorable symposium on "Myocardial Contractility," edited by R. D. Tanz, F. Kavaler and J. Roberts (New York and London, Academic Press, 1967). PathogeneSis of myocardial failure still involves many questions. The latest scien­ tific findings on fundamentals of myocardial contraction encouraged us to organize this international symposium held in Rottach-Egern at Tegernsee (Germany), June 17 to 19, 1976 sponsored by the European Society of Cardio~ogy. It seemed appropriate to assemble prominent workers in this field in an attempt to correlate their respective in­ formation on cardiac function. In this connection it must be remembered that our present understand­ ing of the cardiovascular system and today's therapeutic and preventive measures are the fruits of yesterday's research. Further progress in this field will be conditioned by various circumstances: to win highly motivated creative people for clinical research, to mediate time and contacts for their learning new methods, and to provide adequate faci­ lities for scientific work in our hospitals. Therefore, the aim of the conference was to discuss those aspects of myocardial failure, that are believed to require further studies in the future by integrated efforts of research workers in several disciplines, especially to promote the pertinent exchange of ideas between basic and clinical research. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Introductory Remarks....Pages 2-3 The Structural Basis of Contraction in Muscle and Its Study by Rapid X-Ray Diffraction Methods....Pages 4-15 The Myosin Cross-Bridge as Revealed by Structure Studies....Pages 16-27 Myosin-Linked Regulation: A Chemical Approach....Pages 28-40 Myocardial Cross-Bridge Activity and Its Regulation by Ca ++ , Phosphate and Stretch....Pages 41-51 Myosin Characteristics and Immunological Properties of Myocardial Tissue....Pages 52-64 Concluding Remarks....Pages 65-67 Introductory Remarks....Pages 70-71 Relation of Calcium Permeability to the Ca ++ Concentration Gradient Across the Sarcoplasmic Reticulum....Pages 72-79 Calcium Binding and Cardiac Myofibril Activation....Pages 80-89 Cyclic Nucleotides and Cardiac Contractility....Pages 90-99 Introductory Remarks....Pages 102-103 Biochemical Characteristics of the Sodium Pump: Indications for a Half-of-Sites Reactivity of (Na + + K + )-ATPase....Pages 104-119 Receptor for Cardiac Glycosides....Pages 120-131 Adenylate Cyclase Regulation and ß-Adrenergic Receptors in Guinea-Pig Myocardial Tissue....Pages 132-152 The Role of the Mitochondrial Adenine Nucleotide Transport in Heart....Pages 153-162 Front Matter....Pages 163-163 Introductory Remarks....Pages 164-166 Myocardial Biopsy Techniques....Pages 167-174 Cellular and Subcellular Morphology of Biopsy Material....Pages 175-184 Ultrastructure of Degenerated Muscle Cells in Patients With Cardiac Hypertrophy....Pages 185-200 Front Matter....Pages 163-163 Humoral and Cellular Studies in Diseases With Heart-Reactive Antibodies....Pages 201-208 Relationship Between Pulmonary Artery Pressure and Echocardiographic Mitral Valve Closure in Patients With Acute Myocardial Infarction....Pages 209-219 Echocardiographic Evaluation of Myocardial Perfomance During Infusion of Angiotensin and Handgrip-Exercise....Pages 220-228 Introductory Remarks....Pages 230-231 Classification and Natural History of Primary Cardiomyopathies....Pages 232-250 Myocardial Lesions in Cardiomyopathies....Pages 251-265 Cardiomyopathies Related to Immunological Processes....Pages 266-274 Metabolic Heart Disease With Special Reference to Carbohydrate Metabolism in Health and Disease....Pages 275-290 Front Matter....Pages 291-291 Introductory Remarks....Pages 292-292 Contraction and Relaxation of Heart Muscle as Influenced by cAMP, Isoproterenol, Glucagon, Ouabain, and Calcium....Pages 293-297 Direct Effects of Diuretic Drugs on the Myocardium....Pages 298-310 Circulatory and Contractile Effects of Thyroid Hormones....Pages 311-328 Introductory Remarks....Pages 330-330 On the Inotropic and Arrhythmogenic Effects of Digitalis....Pages 331-343 Beta-Blockers in Myocardial Failure....Pages 344-352 The Hemodynamic Effects of Antiarrhythmic Drugs on the Depressed Myocardium....Pages 353-367 Back Matter....Pages 369-374