Myasthenia Gravis and Myasthenic Disorders (Contemporary Neurology Series, 81)

Myasthenia Gravis and Myasthenic Disorders , Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and the electrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseases collectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segment near the neuromuscular junction-- the syndrome of peripheral nerve hyperexcitability and the Guillain-Barré syndrome. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.
Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and the electrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseases collectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segment near the neuromuscular junction-- the syndrome of peripheral nerve hyperexcitability and the Guillain-Barré syndrome.

Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.

The book contains predominantly black-and-white illustrations, with some color illustrations.

Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and theelectrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseasescollectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segmentnear the neuromuscular junction - the syndrome of peripheral nerve hyperexcitability and the Guillain-Barre syndrome. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come Contents 2 Dedication 3 Preface 4 Contributors 7 The Anatomy and Molecular Architecture of the Neuromuscular Junction 10 Electrodiagnosis of Myasthenic Disorders 65 The Immunopathogenesis of Myasthenia Gravis 97 Natural History of Myasthenia Gravis 138 The Diagnosis of Myasthenia Gravis and Other Disorders of Neuromuscular Transmission 164 Therapy of Myasthenia Gravis 197 The Lambert-Eaton Myasthenic Syndrome 233 Congenital Myasthenic Syndromes 260 Endplate Acetylcholine Receptor, a Target for Myasthenic Disorders: Structural and Mechanistic Essentials 336 Peripheral Nerve Hyperexcitability Syndromes 366 Effects of Anti-ganglioside Antibodies at the Neuromuscular Junction 388 Index 407 9780199738670,-,Myasthenia,Gravis,and,Myasthenic,Disorders 9780199738670 - Myasthenia Gravis and Myasthenic Disorders __Myasthenia Gravis and Myasthenic Disorders__ __Second Edition__Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as text on Myasthenia Gravis and related disorders for years to come.