Muse Cells: Endogenous Reparative Pluripotent Stem Cells (Advances in Experimental Medicine and Biology Book 1103)

"This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications--for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body's reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers." -- prové de l'editor Front Matter ....Pages i-xii The Muse Cell Discovery, Thanks to Wine and Science (Mari Dezawa)....Pages 1-11 Basic Characteristics of Muse Cells (Shohei Wakao, Yoshihiro Kushida, Mari Dezawa)....Pages 13-41 Muse Cells Are Endogenous Reparative Stem Cells (Yoshihiro Kushida, Shohei Wakao, Mari Dezawa)....Pages 43-68 Protocols for Isolation and Evaluation of Muse Cells (Kazuki Tatsumi, Yoshihiro Kushida, Shohei Wakao, Yasumasa Kuroda, Mari Dezawa)....Pages 69-101 Stem Cells and DNA Repair Capacity: Muse Stem Cells Are Among the Best Performers (Tiziana Squillaro, Nicola Alessio, Giovanni Di Bernardo, Servet Özcan, Gianfranco Peluso, Umberto Galderisi)....Pages 103-113 Immunomodulatory Properties and Potential Therapeutic Benefits of Muse Cells Administration in Diabetes (Marcelo Javier Perone, María Laura Gimeno, Florencia Fuertes)....Pages 115-129 The Role of the Mitochondria in the Evolution of Stem Cells, Including MUSE Stem Cells and Their Biology (James E. Trosko)....Pages 131-152 Acute Myocardial Infarction, Cardioprotection, and Muse Cells (Shinya Minatoguchi, Atsushi Mikami, Toshiki Tanaka, Shingo Minatoguchi, Yoshihisa Yamada)....Pages 153-166 Application of Muse Cell Therapy to Stroke (Kuniyasu Niizuma, Cesar V. Borlongan, Teiji Tominaga)....Pages 167-186 Muse Cell: A New Paradigm for Cell Therapy and Regenerative Homeostasis in Ischemic Stroke (Satoshi Kuroda, Masaki Koh, Emiko Hori, Yumiko Hayakawa, Takuya Akai)....Pages 187-198 Application of Muse Cell Therapy for Kidney Diseases (Nao Uchida, Naonori Kumagai, Yoshiaki Kondo)....Pages 199-218 Liver Regeneration Supported by Muse Cells (Satoshi S. Nishizuka, Yuji Suzuki, Hirokatsu Katagiri, Yasuhiro Takikawa)....Pages 219-241 Current Cell-Based Therapies in the Chronic Liver Diseases (Taketo Nishina, Kyoko Tomita Hoshikawa, Yoshiyuki Ueno)....Pages 243-253 Artificial Pigmented Human Skin Created by Muse Cells (Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Setsuya Aiba)....Pages 255-271 Muse Cells and Aortic Aneurysm (Katsuhiro Hosoyama, Yoshikatsu Saiki)....Pages 273-291 Muse Cells and Ischemia-Reperfusion Lung Injury (Hiroshi Yabuki, Tatsuaki Watanabe, Hisashi Oishi, Masato Katahira, Masahiko Kanehira, Yoshinori Okada)....Pages 293-303 Clinical Trials of Muse Cells (Mari Dezawa)....Pages 305-307 Future of Muse Cells (Wise Young)....Pages 309-315 This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications--for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body's reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph. D. students, postdocs, basic researchers, clinical doctors, and industrial developers