Musculoskeletal Tissue Regeneration: Biological Materials and Methods (Orthopedic Biology and Medicine)

The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts in their field, Musculoskeletal Tissue Regeneration: Biological Materials and Methods aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. On the cusp of a revolution, musculoskeletal repair is based on new tools that have recently become available or are about to emerge into clinical practice. By their very nature, these tools require an interdisciplinary approach, utilizing teams comprised of surgeons, engineers, and scientists in collaboration between industry and academia. A valuable resource for researchers, developers, and clinicians, Musculoskeletal Tissue Regeneration: Biological Materials and Methods presents a foundation to propel the technology and integration of the current state of knowledge into the twenty-first century. Front Matter....Pages i-xxi Musculoskeletal and Wound Treatment Through the Ages: A Brief Historical Tour ....Pages 3-17 Musculoskeletal Fundamentals: Form, Function, and a Survey of Healing Strategies ....Pages 19-38 Overview of Fracture Repair....Pages 39-61 Autograft Bone....Pages 65-79 Biology of Bone Allograft and Clinical Application....Pages 81-92 Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation ....Pages 93-117 Deproteinized Bovine Bone Xenograft....Pages 119-151 Bioactive Bioceramics....Pages 153-181 Distraction Osteogenesis of the Orthopedic Skeleton: Basic Principles and Clinical Applications ....Pages 183-198 Distraction Osteogenesis of the Facial Skeleton....Pages 199-224 Bone Morphogenetic Proteins and Other Bone Growth Factors....Pages 225-245 Biological Approaches to Spinal Fusion....Pages 247-258 Electrical Bone Stimulation....Pages 259-287 Meniscus Repair Techniques....Pages 291-311 Lessons Learned From Our First 100 Meniscus Allograft Transplants in Arthritic Knees....Pages 313-325 Tissue Engineering of the Meniscus....Pages 327-346 Osteochondral Grafts....Pages 347-368 Autologous Chondrocyte Cartilage Repair....Pages 369-394 Autograft and Allograft ACL Reconstruction: Construct Rationale ....Pages 395-417 Tissue Engineered Anterior Cruciate Ligament Graft....Pages 419-442 Biologic Scaffold Materials for Orthopaedic Soft Tissue Reconstruction....Pages 443-457 Muscle Repair after Injury and Disease....Pages 459-480 Principles of Musculoskeletal Tissue Banking....Pages 483-508 Bioabsorbable Polymer Applications in Musculoskeletal Fixation and Healing....Pages 509-529 Tissue Adhesives: Science, Products, and Clinical Use ....Pages 531-546 Platelet-Rich Plasma in Orthopedics....Pages 547-568 Gene Therapy Approaches for Musculoskeletal Tissue Regeneration....Pages 569-591 Paradigms of Tissue Engineering with Applications to Cartilage Regeneration....Pages 593-615 The Future of Musculoskeletal Tissue Regeneration: A Clinical Perspective ....Pages 619-634 Back Matter....Pages 635-649 Tissue engineering and regenerative medicine will ultimately have a more profound impact than most of us can fully appreciate. The combination of the principles of engineering with advances in the material sciences, and an increased understanding of developmental biology has the potential to influence developments in medicine and biotechnology more than any single advance in these fields during the last several decades. I would first like to applaud the volume editor, Dr. Pietrzak, and the authors for their efforts in bringing together a group of interrelated topics to create a textbook emphasizing the Tissue Engineered generation of musculoskeletal tissue. The authors of this book are all established experts in their respective fields. The publication of a separate volume dedicated to musculoskeletal tissue regeneration as part of a series focusing on orthopedic biology and medicine is a reflection of the tremendous growth of knowledge and ongoing developments that have occurred in this field over the last decade. Musculoskeletal Tissue Regeneration: Biological Materials and Methods is intended to cover the basic fundamentals and early treatment of musculoskeletal disease, tissue loss and wound healing, as well as provide a comprehensive summary of recent advances in regenerative medicine and tissue engineering as they relate to the musculoskeletal system, and should serve as a reference for researchers and graduate students in this discipline. The Repair Of Musculoskeletal Tissue Is A Vital Concern Of All Surgical Specialties, Orthopedics And Related Disciplines. This Book Aims To Provide Both Basic And Advanced Knowledge Of The Newer Methodologies Being Developed And Introduced To The Clinical Arena. On The Cusp Of A Revolution, Musculoskeletal Repair Is Based On New Tools That Have Recently Become Available Or Are About To Emerge Into Clinical Practice. By Their Very Nature, These Tools Require An Interdisciplinary Approach, Utilizing Teams Comprised Of Surgeons, Engineers, And Scientists In Collaboration Between Industry And Academia. Edited By Wiliam S. Pietrzak ; Foreword By Charles A. Vacanti. Includes Bibliographical References And Index. The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.