مجموعه دو جلدی عضله: زیست‌شناسی بنیادی و مکانیسم‌های بیماری

* ''This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe.''--**Reference & Research Book News October 2012** Content: Front-matter , Pages i,iii Copyright , Page iv List of Contributors , Pages ix-xvii , Paul D. Allen, Ovid C. Amadi, Mark Anderson, Daniel C. Andersson, Stephen L. Archer, Andrea L.H. Arnett, Richard Arnoldi, Sarah Arrowsmith, Elisabeth R. Barton, Rhonda Bassel-Duby, Stephen L. Belmonte, Rabah Ben Yaou, Ivor J. Benjamin, Bradford C. Berk, Donald M. Bers, Anne T. Bertrand, Matthew J. Betzenhauser, Morris J. Birnbaum, Brian L. Black, Burns C. Blaxall, et al. Acknowledgments , Page xix , Joseph A. Hill, Eric N. Olson Chapter 1 - An Introduction to Muscle , Pages 3-9 , Joseph A. Hill, Eric N. Olson Chapter 2 - A History of Muscle , Pages 11-20 , Arnold M. Katz Chapter 3 - Cardiac Myocyte Specification and Differentiation , Pages 25-34 , Benoit G. Bruneau, Brian L. Black Chapter 4 - Transcriptional Control of Cardiogenesis , Pages 35-46 , Katherine E. Yutzey Chapter 5 - Cardiomyocyte Ultrastructure , Pages 47-55 , A. Martin Gerdes Chapter 6 - Overview of Cardiac Muscle Physiology , Pages 57-66 , John W. Calvert, David J. Lefer Chapter 7 - Ionic Fluxes and Genesis of the Cardiac Action Potential , Pages 67-85 , Yanggan Wang, Deeptankar DeMazumder, Joseph A. Hill Chapter 8 - G-Protein-Coupled Receptors in the Heart , Pages 87-112 , Melissa L. Martin, Stephen L. Belmonte, Rashmi Ram, Fadia A. Kamal, Burns C. Blaxall Chapter 9 - Receptor Tyrosine Kinases in Cardiac Muscle , Pages 113-126 , Tiffany L. Shih, Aarif Y. Khakoo Chapter 10 - Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network , Pages 127-139 , Shirin Doroudgar, Christopher C. Glembotski Chapter 11 - Calcium Fluxes and Homeostasis , Pages 141-152 , Donald M. Bers, Steven R. Houser Chapter 12 - Excitation–Contraction Coupling in the Heart , Pages 153-159 , Daniel C. Andersson, Matthew J. Betzenhauser, Andrew R. Marks Chapter 13 - Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle , Pages 161-172 , R. John Solaro, Leslie A. Leinwand Chapter 14 - Cardiovascular Mechanotransduction , Pages 173-186 , Stephan Dobner, Ovid C. Amadi, Richard T. Lee Chapter 15 - Cardiomyocyte Metabolism: All Is in Flux , Pages 187-202 , Heinrich Taegtmeyer Chapter 16 - Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function , Pages 203-215 , Daniel P. Kelly, Richard C. Scarpulla Chapter 17 - Mitochondrial Morphology and Function , Pages 217-229 , Fabio Di Lisa, Luca Scorrano Chapter 18 - Genetics and Genomics in Cardiovascular Gene Discovery , Pages 231-259 , Aravinda Chakravarti, Ashish Kapoor Chapter 19 - Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications , Pages 261-271 , Miroslava Stastna, Pingbo Zhang, Anne Murphy, Jennifer E. Van Eyk Chapter 20 - Adaption and Responses: Myocardial Innervations and Neural Control , Pages 275-284 , Neil Herring, David J. Paterson Chapter 21 - Regulation of Cardiac Systolic Function and Contractility , Pages 285-297 , Eiki Takimoto, David A. Kass Chapter 22 - Intracellular Signaling Pathways in Cardiac Remodeling , Pages 299-308 , Yibin Wang, Mark Anderson Chapter 23 - Oxidative Stress and Cardiac Muscle , Pages 309-322 , Yasuhiro Maejima, Daniela Zablocki, Junichi Sadoshima Chapter 24 - Physiologic and Molecular Responses of the Heart to Chronic Exercise , Pages 323-330 , Benjamin Levine, Peter Buttrick Chapter 25 - Epigenetics in Cardiovascular Biology , Pages 331-340 , Roberto Papait, Paola Cattaneo, Michael V.G. Latronico, Gianluigi Condorelli Chapter 26 - Cardiac MicroRNAs , Pages 341-351 , Eva van Rooij Chapter 27 - Protein Quality Control in Cardiomyocytes , Pages 353-367 , Xuejun Wang, Cam Patterson Chapter 28 - Cardioprotection , Pages 369-388 , David J. Lefer, Roberto Bolli Chapter 29 - Cardiac Fibrosis: Cellular and Molecular Determinants , Pages 389-404 , Hasse Brønnum, Raghu Kalluri Chapter 30 - Autophagy in Cardiac Physiology and Disease , Pages 405-422 , Joseph A. Hill, Sergio Lavandero, Beverly A. Rothermel Chapter 31 - Programmed Cardiomyocyte Death in Heart Disease , Pages 423-446 , Gerald W Dorn II, Richard N. Kitsis Chapter 32 - Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation , Pages 447-456 , Ethan David Cohen, Edward E. Morrisey Chapter 33 - Congenital Cardiomyopathies , Pages 459-472 , Jeffrey A. Towbin, Stephanie Ware, John Lynn Jefferies Chapter 34 - Genetics of Congenital Heart Disease , Pages 473-480 , Bruce D. Gelb, Stephanie E. Chin Chapter 35 - Mechanisms of Stress-Induced Cardiac Hypertrophy , Pages 481-494 , Norbert Frey, Eric N. Olson, Joseph A. Hill Chapter 36 - Ischemic Heart Disease , Pages 495-521 , Charles Steenbergen, Nikolaos G. Frangogiannis Chapter 37 - The Pathophysiology of Heart Failure , Pages 523-535 , Anthony J. Muslin Chapter 38 - The Right Ventricle: Reemergence of the Forgotten Ventricle , Pages 537-553 , Stephen L. Archer, John J. Ryan, Stuart Rich, Sandeep Nathan, Kevin Tsai, Amit R. Patel, Yong-Hu Fang, Lin Piao Chapter 39 - Mammalian Myocardial Regeneration , Pages 555-569 , Bin Zhou, Zhiqiang Lin, William T. Pu Chapter 40 - The Structural Basis of Arrhythmia , Pages 571-582 , Eugene Kim, Glenn I. Fishman Chapter 41 - Molecular and Cellular Mechanisms of Cardiac Arrhythmias , Pages 583-599 , Deeptankar DeMazumder, Gordon F. Tomaselli Chapter 42 - Genetic Mechanisms of Arrhythmia , Pages 601-623 , Silvia G Priori, Carlo Napolitano, Calum A. MacRae Chapter 43 - Infiltrative and Protein Misfolding Myocardial Diseases , Pages 625-637 , Hamilton S. Gillespie, Ivor J. Benjamin Chapter 44 - Cardiac Aging: From Humans to Molecules , Pages 639-659 , James B. Strait, Edward G. Lakatta Chapter 45 - Adrenergic Receptor Polymorphisms in Heart Failure , Pages 661-672 , Stephen B. Liggett Chapter 46 - Cardiac Gene Therapy , Pages 673-688 , Roger J. Hajjar Chapter 47 - Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics , Pages 689-696 , Aarif Y. Khakoo, Thomas Force Chapter 48 - Cell Therapy for Cardiac Disease , Pages 697-705 , R. Kannan Mutharasan, Douglas W. Losordo Chapter 49 - Chemical Genetics of Cardiac Regeneration , Pages 707-720 , Jay W. Schneider, Mark Mercola Chapter 50 - Device Therapy for Systolic Ventricular Failure , Pages 721-737 , J. Eduardo Rame, David Spragg Chapter 51 - Novel Therapeutic Targets and Strategies against Myocardial Diseases , Pages 739-744 , Atsuhiko T. Naito, Ichiro Shiojima, Issei Komuro Chapter 52 - Skeletal Muscle Development , Pages 749-762 , Margaret Buckingham, Alicia Mayeuf Chapter 53 - Skeletal Muscle: Architecture of Membrane Systems , Pages 763-774 , Clara Franzini-Armstrong, Andrew G. Engel Chapter 54 - The Vertebrate Neuromuscular Junction , Pages 775-787 , Young il Lee, Wesley J. Thompson Chapter 55 - Neuromechanical Interactions that Control Muscle Function and Adaptation , Pages 789-800 , Jung A. Kim, Roland R. Roy, V. Reggie Edgerton Chapter 56 - Control of Resting Ca 2+ Concentration in Skeletal Muscle , Pages 801-810 , Jose R. Lopez, Paul D. Allen Chapter 57 - Skeletal Muscle Excitation–Contraction Coupling , Pages 811-821 , Martin F. Schneider, Erick O. Hernández-Ochoa Chapter 58 - The Contractile Machinery of Skeletal Muscle , Pages 823-840 , Clara Franzini-Armstrong, H. Lee Sweeney Chapter 59 - Skeletal Muscle Metabolism , Pages 841-853 , Morris J. Birnbaum Chapter 60 - Skeletal Muscle Fiber Types , Pages 855-867 , Stefano Schiaffino, Carlo Reggiani Chapter 61 - Regulation of Skeletal Muscle Development and Function by microRNAs , Pages 871-880 , Ning Liu, Rhonda Bassel-Duby Chapter 62 - Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects , Pages 881-897 , Burhan Gharaibeh, Bridget Deasy, Mitra Lavasani, James H. Cummins, Yong Li, Johnny Huard Chapter 63 - Immunological Responses to Muscle Injury , Pages 899-909 , James G. Tidball, Chiara Rinaldi Chapter 64 - Skeletal Muscle Adaptation to Exercise , Pages 911-920 , John J. McCarthy, Karyn A. Esser Chapter 65 - Skeletal Muscle Regeneration , Pages 921-933 , Denis C. Guttridge Chapter 66 - Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular Dystrophy , Pages 935-942 , Yvonne M. Kobayashi, Kevin P. Campbell Chapter 67 - Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk , Pages 945-954 , QiPing Feng, Russell A. Wilke Chapter 68 - Myotonic Dystrophy , Pages 955-968 , Charles Thornton Chapter 69 - Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease , Pages 969-977 , Charis L. Himeda, Charles P. Emerson Jr Chapter 70 - ECM-Related Myopathies and Muscular Dystrophies , Pages 979-994 , Carsten G. Bönnemann, Nicol C. Voermans Chapter 71 - Molecular Pathogenesis of Skeletal Muscle Abnormalities in Marfan Syndrome , Pages 995-1001 , Ronald D. Cohn, Harry C. Dietz III Chapter 72 - Diseases of the Nucleoskeleton , Pages 1003-1012 , Anne T. Bertrand, Rabah Ben Yaou, Gisèle Bonne Chapter 73 - Channelopathies of Skeletal Muscle Excitability , Pages 1013-1022 , Stephen C. Cannon Chapter 74 - Thick and Thin Filament Proteins: Acquired and Hereditary Sarcomeric Protein Diseases , Pages 1023-1030 , Julien Ochala, Lars Larsson Chapter 75 - Metabolic and Mitochondrial Myopathies , Pages 1031-1041 , Ronald G. Haller, Salvatore DiMauro Chapter 76 - Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors , Pages 1045-1051 , Andrea L.H. Arnett, Julian N. Ramos, Jeffrey S. Chamberlain Chapter 77 - Cell-Based Therapies in Skeletal Muscle Disease , Pages 1053-1063 , Denis Vallese, Erica Yada, Gillian Butler-Browne, Vincent Mouly Chapter 78 - Immunological Components of Genetically Inherited Muscular Dystrophies: Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy Type 2B , Pages 1065-1075 , Melissa J. Spencer, Irina Kramerova, M. Carrie Miceli, Kanneboyina Nagaraju Chapter 79 - Myostatin: Regulation, Function, and Therapeutic Applications , Pages 1077-1084 , Se-Jin Lee Chapter 80 - Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle Growth and Repair , Pages 1085-1093 , Elisabeth R. Barton Chapter 81 - Novel Targets and Approaches to Treating Skeletal Muscle Disease , Pages 1095-1103 , Elizabeth McNally Chapter 82 - Development of the Smooth Muscle Cell Lineage , Pages 1109-1116 , Nina Bowens, Michael S. Parmacek Chapter 83 - Smooth Muscle Myocyte Ultrastructure and Contractility , Pages 1117-1132 , Avril V. Somlyo, Marion J. Siegman Chapter 84 - Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells , Pages 1133-1143 , Keshari M. Thakali, Asif R. Pathan, Sujay V. Kharade, Nancy J. Rusch Chapter 85 - G-Protein-Coupled Receptors in Smooth Muscle , Pages 1145-1153 , Angela Wirth, Stefan Offermanns Chapter 86 - Calcium Homeostasis and Signaling in Smooth Muscle , Pages 1155-1171 , Theodor Burdyga, Richard J. Paul Chapter 87 - Regulation of Smooth Muscle Contraction , Pages 1173-1180 , Susanne Vetterkind, Kathleen G. Morgan Chapter 88 - Heterogeneity of Smooth Muscle , Pages 1183-1195 , Richard Arnoldi, Christine Chaponnier, Giulio Gabbiani, Boris Hinz Chapter 89 - Microcirculation , Pages 1197-1206 , William F. Jackson Chapter 90 - Uterine Smooth Muscle , Pages 1207-1216 , Susan Wray, Sarah Arrowsmith Chapter 91 - Oxidative Stress, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling , Pages 1219-1229 , Thomas Münzel, Tommaso Gori Chapter 92 - Hemodynamic Control of Vascular Smooth Muscle Function , Pages 1231-1242 , Eileen M. Redmond, Caitriona Lally, Paul A. Cahill Chapter 93 - Myogenic Tone and Mechanotransduction , Pages 1243-1257 , Michael A. Hill, Gerald A. Meininger Chapter 94 - Cell–Cell Communication Through Gap Junctions , Pages 1259-1268 , Cor de Wit Chapter 95 - Vascular Smooth Muscle Cell Phenotypic Adaptation , Pages 1269-1278 , Joseph M. Miano Chapter 96 - Molecular Pathways of Smooth Muscle Disease , Pages 1279-1287 , Alejandra San Martín, Lula Hilenski, Kathy K. Griendling Chapter 97 - Genetic Variants in Smooth Muscle Contraction and Adhesion Genes Cause Thoracic Aortic Aneurysms and Dissections and Other Vascular Diseases , Pages 1291-1300 , Dianna M. Milewicz, Callie S. Kwartler Chapter 98 - Vascular Smooth Muscle Cell Remodeling in Atherosclerosis and Restenosis , Pages 1301-1309 , Elaine Smolock, Bradford C. Berk Chapter 99 - Arterial Hypertension , Pages 1311-1319 , Rhian M. Touyz, Ernesto L. Schiffrin Chapter 100 - Diabetic Vascular Disease , Pages 1321-1328 , Adam Whaley-Connell, Hanrui Zhang, Cuihua Zhang, James R. Sowers Chapter 101 - Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia , Pages 1329-1337 , Eric M. George, Joey P. Granger Chapter 102 - Erectile Dysfunction , Pages 1339-1346 , Kelvin P. Davies Chapter 103 - Smooth Muscle in the Normal and Diseased Pulmonary Circulation , Pages 1347-1358 , Michael E. Yeager, Maria G. Frid, Eva Nozik-Grayck, Kurt R. Stenmark Chapter 104 - Airway Smooth Muscle and Asthma , Pages 1359-1369 , Susan J. Gunst Chapter 105 - Aging , Pages 1371-1381 , Luigi Giusto Spagnoli, Alessandro Mauriello, Augusto Orlandi, Manuel Scimeca, Antonio Volpe, Elena Bonanno Chapter 106 - Vascular Calcification , Pages 1383-1389 , Linda Demer, Yin Tintut Chapter 107 - Smooth Muscle Progenitor Cells: A Novel Target for the Treatment of Vascular Disease? , Pages 1391-1400 , Andreas Schober, Zhou Zhe, Christian Weber Chapter 108 - Smooth Muscle: Novel Targets and Therapeutic Approaches , Pages 1401-1408 , Mark W. Majesky Glossary , Pages G1-G12 Index , Pages I1-I27 Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Diseas e will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. As stated by a reviewer of the proposal, "An integration of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases is highly desirable. I am not aware of a comprehensive book that covers and integrates these topics."--Maik Huttemann, Wayne State University, MI. Per the National Institute of Arthritis and Musculoskeletal and Skin Disease, an institute at the National Institutes of Health, "clinical investigators are sorely needed to translate an ever increasing number of basic research findings into medical applications". This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge

A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.

Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

• The only resource to focus on science before the clinical work and therapeutics
• Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions
• Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth

A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit. The only resource to focus on science before the clinical work and therapeutics Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth Muscle: Fundamental Biology And Mechanisms Of Disease Will Be The First Reference Covering Cardiac, Skeletal, And Smooth Muscle In Fundamental, Basic Science, Translational Biology, Disease Mechanism, And Therapeutics. Currently There Are No Publications Covering The Science Behind The Medicine, As The Majority Of Books Are 90% Clinical And 10% Science. Muscle: Fundamental Biology And Mechanisms Of Disease Will Discuss Myocyte Biology, Also Known As Muscle Cell Biology, Providing Information About The Science Behind Clinical Work And Therapeutics With A 90% Science And 10% Clinical Focus. A Needed Resource For Researchers, Clinical Professionals, Postdocs, And Graduate Students, This Publication Will Further Discuss Basic Biology Development And Physiology, How Processes Go Awry In Disease States, And How The Defective Pathways Are Targeted For Therapy. This Book Will Assist Both The New And Experienced Clinician's And Researcher's Need For Science Translation Of Background Research Into Clinical Applications, Bridging The Gap Between Research And Clinical Knowledge. Pt. 1. Introduction -- Pt. 2. Cardiac Muscle -- Pt. 3. Skeletal Muscle -- Pt. 4. Smooth Muscle. Edited By Joseph A. Hill And Eric N. Olson ; Section Editors, Kathy K. Griendling ... [et Al.]. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. ''This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe.''-- Reference & Research Book News October 2012