Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles: Application to Drug Delivery System (Iop Concise Physics)

Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow. PRELIMS.pdf 1 Preface 8 Acknowledgements 10 Author biographies 11 Huilin Ye 11 Zhiqiang Shen 11 Ying Li 11 Symbols 12 CH001.pdf 1 Chapter 1 Background 13 1.1 Blood flow in human vasculature 13 1.2 Vascular targeting and margination of particles in blood flow 14 1.3 Adhesion of particles on endothelium wall 17 References 18 CH002.pdf 1 Chapter 2 Numerical methods: fluid–structure interaction and adhesive dynamics 25 2.1 Fluid–structure interaction 25 2.1.1 Plasma dynamics: lattice Boltzmann method 25 2.1.2 Coarse-grained model for blood cells and particles 28 2.1.3 Immersed boundary method 30 2.2 Adhesive dynamics 33 2.3 Validation of numerical method 34 2.3.1 Validation of red blood cell model 34 2.3.2 Validation of red blood cell suspension 38 References 41 CH003.pdf 1 Chapter 3 Anomalous vascular dynamics of nanoworms within blood flow 45 3.1 Motivation 45 3.2 Experimental and computational results 47 3.2.1 Experiment 47 3.2.2 Computational results 48 References 58 CH004.pdf 1 Chapter 4 Adhesion behavior of a single cell on the endothelial wall 60 4.1 Introduction 60 4.2 Computational model 61 4.3 Results and discussion 63 4.3.1 Four types of motion and demargination 63 4.3.2 Effect of particle stiffness on the formation of bonds and adhesive force 64 4.3.3 Phase diagram and scaling relationship 66 References 66 CH005.pdf 1 Chapter 5 Localization of soft particles: margination and adhesion 68 5.1 Introduction 69 5.2 Physical problem and computational method 70 5.2.1 Physical problem 70 5.3 Results and discussion 71 5.3.1 Margination of elastic MPs without adhesion 72 5.3.2 Adhesion effect on localization of elastic MPs at the wall 75 5.3.3 Adhesion behavior of elastic MPs 77 5.3.4 Mechanism of localization of elastic MPs under adhesion 79 References 84 CH006.pdf 1 Chapter 6 Shape-dependent transport of micro-particles in blood flow: from margination to adhesion 88 6.1 Introduction 89 6.2 Computational model setup 91 6.3 Results and discussion 92 6.3.1 Margination of MPs without adhesion 92 6.3.2 Margination of MPs with adhesion 97 6.3.3 Mechanism of adhesion effect on margination behavior 101 References 104 CH007.pdf 1 Chapter 7 Conclusion and perspective 106 References 109 APP1.pdf 1 Chapter 110 Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow To study the transport and adhesion of particle in vasculature, this study numerically investigates the dynamic and adhesive motions of particles in the blood flow. The book discusses recent achievements, from the establishment of fundamental physical problem to development of a multiscale model, and large scale simulations.