Multiple Sclerosis - The History of a Disease : the History of a Disease

Annotation In This Elegantly Written And Comprehensive History, We Meet Individuals Who Suffered With Ms In The Centuries Before The Disease Had A Name. From These Early Cases The Author Demonstrates How Progress In Diagnosing And Managing Multiple Sclerosis Has Paralleled Breakthroughs In Medical Science, From Early Developments In Modern Studies Of Anatomy And Pathology, To The Framing Of The Disease In The Nineteenth Century, And Eventually To Modern Diagnosis And Treatment. From Beginning To End, Dr. Murray Takes Us On A Fascinating Journey Of Discovery, Showing How The Evolution Of Our Understanding Of Multiple Sclerosis Has Been Part Of The Greater History Of Medical Knowledge. Annotation Scholarly And Wide-ranging, This New, Extensively-illustrated Book Provides A Historical Survey And Social History Of Multiple Sclerosis And Is Rich In Sources And Detail. Annotation The Basic Facts About Multiple Sclerosis Are Well Known: It Is The Most Common Neurologic Disease Of Young Adults, Usually Beginning With Episodic Attacks Of Neurologic Symptoms, Then Entering A Progressive Phase Some Years Later. Its Onset Has An Average Age Of 30, And Occurs In About 1 In 500 Individuals Of European Ancestry Living Primarily In Temperate Climates. There Appears To Be A Complex Interaction Between A Genetic Predisposition And An Environmental Trigger That Initiates The Disease. But These Facts Do Not Convey The Impact Of The Disease On The People Whose Lives It Affects. In This Elegantly Written And Comprehensive History, We Meet Individuals Who Suffered With Ms In The Centuries Before The Disease Had A Name, Including Blessed Lidwina Of Holland, Who Took Joy From Her Misery, Believing That She Was Sent To Accept Suffering For The Sins Of Others; Augustus D'est??, Grandson Of George Iii And Cousin Of Queen Victoria, Whose Case Shows How Someone With Access To The Best Of Medical Care Of The Age Was Understood And Managed; And Heinrich Heine, The Great German Poet, Who Also Had Access To All Medical Services That Were Available, But Who Progressed Into His Mattress Grave In Two Decades, Aware Of The Loss Of Physical Ability While Still Able To Compose Great Poetry To The End. From These Early Cases The Author Demonstrates How Progress In Diagnosing And Managing Multiple Sclerosis Has Paralleled The Development Of Medical Science, From The Early Developments In Modern Studies Of Anatomy And Pathology, To The Framing Of The Disease In The Nineteenth Century, And Eventually To Modern Diagnosis And Treatment. From Beginning To End, Dr. Murray Takes Us On A Fascinating Journey Of Discovery, In The Process Showing How The Evolution Of Our Understanding Of Multiple Sclerosis Has Been Part Of The Greater History Of Medical Knowledge. Terminology And Disease Description -- The Framing Of Multiple Sclerosis -- The Palsy Without A Name: Suffering With Paraplegia -- The Steps Towards A Recovery : The Early Medical Reports The Building Blocks Of A Discovery -- The Contribution Of J.m. Charcot 1868 -- The Medical Reports After Charcot -- Clarifying The Pathology : James Dawson -- The Journal Of A Disappointed Man -- Experimentation, Meetings, Reviews,and Symposia, 1920-1960 -- Searching For A Cause Of Ms -- Classifying And Measuring Ms -- The Nature Of The Ms Plaque -- Investigations -- Searching For Therapy -- Ms And The Public: Societies, Narratives And The Media. T. Jock Murray. Includes Bibliographical References And Index. Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal!

The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease.

But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end.

From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment.

From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge. Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge. Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! Click here to learn more about the ForeWord Book of the Year Awards. The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Estv©, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating Title Page 5 Table of Contents 9 Acknowledgments 11 Foreword 13 Chapter 1: Terminology and Disease Description 15 Chapter 2: The Framing of Multiple Sclerosis 27 Chapter 3: The Palsy without a Name: Suffering with Paraplegia 1395–1868 33 Chapter 4: The Steps Toward a Discovery: The Early Medical Reports 75 Chapter 5: The Building Blocks of a Discovery 109 Chapter 6: The Contribution of J.M. Charcot—1868 117 Chapter 7: Medical Reports After Charcot 153 Chapter 8: Clarifying the Pathology: James Dawson 203 Chapter 9: The Journal of a Disappointed Man 209 Chapter 10: Experimentation, Meetings, Reviews, and Symposia, 1920–1960 217 Chapter 11: Searching for a Cause of MS 243 Chapter 12: Classifying and Measuring MS 333 Chapter 13: The Nature of the MS Plaque 351 Chapter 14: Investigations 377 Chapter 15: Searching for Therapy 405 Chapter 16: Multiple Sclerosis and the Public: Societies, Narratives, and the Media 519 Afterword 543 A Chronology of Events in the History of MS 549 Index 563 A 563 B 565 C 566 D 570 E 572 F 574 G 575 H 576 I 577 J 578 K 579 L 579 M 580 N 583 O 584 P 584 Q 587 R 587 S 588 T 590 U 592 V 592 W 593 X 594 Y 594 Z 594 1888799803,9781888799804 Demos Health