Multimodal Concepts for Integration of Cytotoxic Drugs (Medical Radiology / Radiation Oncology)

Over recent decades, combined modality treatment has drastically improved the cure rates for various malignant tumors. Further progress is expected through the design of sound combinations involving recently developed drugs. The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. The text, written by acknowledged experts, is specifically designed to be accessible to professionals from the various disciplines involved in multidisciplinary cancer care and to residents in radiation oncology training programs. Over Recent Decades, Combined Modality Treatment Has Drastically Improved The Cure Rates For Various Malignant Tumors. Further Progress Is Expected Through The Design Of Sound Combinations Involving Recently Developed Drugs. The First Part Of This Book Summarizes The Rationale And The Preclinical Data For Combined Treatment With Ionizing Radiation And Pharmaceutical Agents. Individual Chapters Focus On Different Forms Of Combined Treatment, With Due Consideration Being Given To A Range Of Drugs And To Emerging Combinations With Small Molecules And Antibodies. The Second Part Of The Book Comprises A Series Of Disease-specific Chapters In Which The Clinical Results Of Combined Modality Treatment Are Presented. 1. Biological Basis Of Combined Radio- And Chemotherapy / Claus Belka, Carsten Nieder And Michael Molls -- 2. Combinations Of Antimetabolites And Ionizing Radiation / Hiroshi Harada, Keiko Shibuya And Masahiro Hiraoka -- 3. Combinations Of Taxanes And Ionizing Radiation / Luka Milas, Kathryn A. Mason, Zhongxing Liao And Kian K. Ang -- 4. Combinations Of Topoisomerase Inhibitors And Ionizing Radiation / Michael Bastasch And Hak Choy -- 5. Combinations Of Hypoxia-targeting Compounds And Radiation-activated Prodrugs With Ionizing Radiation / G-one Ahn And J. Martin Brown -- 6. Combinations Of Platinum Compounds And Ionizing Radiation / Carsten Nieder And Florian Lordick -- 7. Combinations Of Cytotoxic Drugs, Ionizing Radiation And Angiogenesis Inhibitors / Carsten Nieder And Nicolaus H. Andratschke -- 8. Combinations Of Cytotoxic Drugs, Ionizing Radiation And Egfr Inhibitors / Guido Lammering -- 9. Combinations Of Cytotoxic Drugs, Ionizing Radiation And Mammalian Target Of Rapamycin (mtor) Inhibitors / Jann N. Sarkaria -- 10. Combinations Of Ionizing Radiation And Other Sensitizing Agents / Minesh P. Mehta -- 11. Radiotherapy And Tumor-targeted Drug Delivery / Zhaozhong Han, Ghazal Hariri And Dennis E. Hallahan -- 12. Applications In Malignant Brain Tumors / Carsten Nieder And Mark R. Gilbert -- 13. Applications In Head And Neck Cancer / Deepak Khuntia, Anne M. Traynor, Paul M. Harari And Jean Bourhis -- 14. Applications In Esophageal And Gastric Cancer / Frank Zimmermann And Bjorn L. D. M. Brucher -- 15. Novel Chemoradiation In Localized Pancreatic Cancer : Clinical Studies / Christopher H. Crane, Gauri Varadhachary, Peter W. T. Pisters, Douglas B. Evans And Robert A. Wolff -- 16. Applications In Lung Cancer / Jochen Fleckenstein And Christian Rube -- 17. Integration Of Radiation Therapy And Systemic Therapy For Breast Cancer / Seungtaek Choi, Howard D. Thames And Thomas A. Buchholz -- 18. Applications In Rectal And Anal Cancer / Claus Rodel And Rolf Sauer -- 19. Concomitant Radiation And Chemotherapy In Muscle-invasive Bladder Cancer / Jurgen Dunst, Claus Rodel And Anthony Zietman -- 20. Applications To Gynecological Cancers / Anthony W. Fyles, Michael Milosevic And Amit Oza -- 21. Early And Late Treatment-induced Toxicity / Wolfgang Dorr, Dorothea Riesenbeck And Carsten Nieder -- 22. Feasibility Of Combined Chemo- And Radiation Treatment In Elderly/comorbid Patients / Hans Geinitz. J.m. Brown, M.p. Mehta, C. Nieder (eds.) ; With Contributions By G-one Ahn ... [et Al.] ; Series Editor's Foreword By L.w. Brady, H.-p. Heilmann, M. Molls. Includes Bibliographical References And Index. Volume 2 is a companion to Volume 1. It is a comprehensive description of satellite remote sensing applications to all aspects of polar glaciology, including not only ice sheets but also icebergs and interactions between ice sheets and the atmosphere and the ocean. It also includes a chapter on the important new field of satellite synthetic-aperture rader interfermetry. There should be something of interest to most polar researchers and those interested in climate research. As in Volume 1, Volume 2 includes a review of the current state of each discipline, including current questions and issues and related suggestions for research applications of satellite remote sensing. There are many satellite remote sensing texts available, but very few are specifically tailored to, or even contain significant information on the Earth's polar regions. The text is sufficiently comprehensive to summarize fundamental principles of detectors, imaging and geophysical product retrieval, in three dedicated chapters. In effect, the text serves as much as possible as a "one stop shop" for polar remote sensing information.; As with Volume 1, the book is extensively referenced, and in an up-to-date fashion. In addition to purely scientific applications, the book also discusses practical and operational issues, such as how polar satellite data can be obtained and how they can be used in expedition planning and logistics. This book is up to date, covering applications of both "heritage" (multi-decadal) remote sensing time series, and new applications from NASA Earth Observing System and similar sensors launched since the year 2000. It also covers future missions