Multidisciplinary Approaches to Theory in Medicine (Volume 3) (Studies in Multidisciplinarity, Volume 3)

This volume will be a collection of chapters from authors with wide experience in their research field. The purpose is to produce a coherent book that reflects the common theme of theory in medical thinking and multidisciplinary research practice. In this context "theory" relates to frameworks of concepts, facts, models etc that help to inform practitioners (clinicians, scientists and engineers) both within their own fields and as they seek to share dialogue with colleagues from other fields. The book will therefore be integrative across a broad spectrum of fields within medicine. To achieve this the chapters will be associated with others in a number of meaningful ways. Each chapter will share a number of points of contact that will include at least two of the following: *similar biomedical area (e.g., immunity, neuroscience, endocrinology, pathology, oncology, haematology, …) *similar multidisciplinary theoretical contexts (e.g., modelling, analysis, description, visualization, complex systems, …) *similar multidisciplinary medical issues and questions (e.g., clinical practice, decision making, informatics, …) · Uniquely explores role of interdisciplinary exchange in the development and expansion of medical theory · Timely and insightful essays on the growth and development of medical theories from some of the world's top clinicians and medical researchers, including Werner Arber, Frank Vertosick, and David Weatherall · Assembles diverse perspectives on medicine and physiology from biology, statistics, ethics, computer science, philosophy, history · Uniquely illuminates the social and historical processes through which theoretical research translates into clinical practice · Reveals the growing role of technology, especially computational modelling, in changing the nature of Western medicine Content: Series dedication Page v William Shakespeare, Hamlet Foreword Pages vii-x Gordon Shepherd Contributors Pages xi-xiv Biographies Pages xv-xxx 1 Disorders of haemoglobin: from phenotype to genotype Original Research Article Pages 1-13 David J. Weatherall 2 Between bleeding and thrombosis or beyond Original Research Article Pages 15-30 Cheng Hock Toh 3 The theory of molecular evolution and its medical implications Original Research Article Pages 31-45 Werner Arber 4 What is a medical theory? Original Research Article Pages 47-62 Paul Thagard 5 Medicine as a moral epistemology Original Research Article Pages 63-88 Alfred I. Tauber 6 Theory in medical education — an oxymoron? Original Research Article Pages 89-102 Sam Leinster 7 Knowledge, arguments, and intentions in clinical decision-making Original Research Article Pages 103-129 John Fox, David Glasspool 8 Analogies, conventions, and expert systems in medicine: some insights from a XIX century physiologist Original Research Article Pages 131-145 Guido Fioretti 9 Reliability of measurements in medical research and clinical practice Original Research Article Pages 147-163 David Y. Downham, Anna Maria Holmbäck, Jan Lexell 10 Advanced data mining and predictive modelling at the core of personalised medicine Original Research Article Pages 165-192 Roland Somogyi, John P. McMichael, Sergio E. Baranzini, Parvin Mousavi, Larry D. Greller 11 Designs and therapies for stochastic neural systems Original Research Article Pages 193-207 Andre Longtin 12 Mining scenarios for hepatitis B and C Original Research Article Pages 209-229 Yukio Ohsawa, Naoaki Okazaki, Naohiro Matsumura, Akio Saiura, Hajime Fujie 13 Modelling the in vivo growth rate of HIV: implications for vaccination Original Research Article Pages 231-246 Ruy M. Ribeiro, Narendra M. Dixit, Alan S. Perelson 14 A flexible, iterative approach to physiological modelling Original Research Article Pages 247-264 Murad Banaji, Stephen Baigent 15 Systems biology, cell specificity, and physiology Original Research Article Pages 265-279 Vincent Detours, Jacques E. Dumont, Carine Maenhaut 16 Modelling T cell activation, proliferation, and homeostasis Original Research Article Pages 281-308 Andrew J. Yates, Cliburn C.T. Chan, Robin E. Callard 17 A theory for complex systems: reactive animation Original Research Article Pages 309-324 Sol Efroni, David Harel, Irun r. Cohen 18 Modelling of haemodynamics in the cardiovascular system by integrating medical imaging techniques and computer modelling tools Original Research Article Pages 325-351 Nigel Bruce Wood, Xiao Yun Xu 19 Vasopressin and homeostasis — running hard to stay in the same place Original Research Article Pages 353-368 Nancy Sabatier, Gareth Leng 20 Mathematical modelling of angiogenesis and vascular adaptation Original Research Article Pages 369-387 Tomas Alarcon, Helen Byrne, Philip Maini, Jasmina Panovska 21 Towards understanding the physical basis of re-entrant cardiac arrhythmias Original Research Article Pages 389-410 Oleg V. Aslanidi, Vadim N. Biktashev, Irina V. Biktasheva, Richard H. Clayton, Arun V. Holden 22 Reflections on the quantitative analysis of liver fibrosis in biopsy specimens Original Research Article Pages 411-429 Nicola Dioguardi 23 A network approach to living tissues Original Research Article Pages 431-445 Frank T. Vertosick Jr. 24 Genetic algorithms in radiotherapy Original Research Article Pages 447-482 Olivier C.L. Haas, Colin R. Reeves 25 Tissue engineering: the multidisciplinary epitome of hope and despair Original Research Article Pages 483-524 David F. Williams Index Pages 525-531 This volume will be a collection of chapters from authors with wide experience in their research field. The purpose is to produce a coherent book that reflects the common theme of theory in medical thinking and multidisciplinary research practice. In this context "theory" relates to frameworks of concepts, facts, models etc that help to inform practitioners (clinicians, scientists and engineers) both within their own fields and as they seek to share dialogue with colleagues from other fields. Multidisciplinary Approaches to Theory in Medicine will therefore be integrative across a broad spectrum of fields within medicine. To achieve this the chapters will be associated with others in a number of meaningful ways. Each chapter will share a number of points of contact that will include at least two of the following: Similar biomedical area (e.g., immunity, neuroscience, endocrinology, pathology, oncology, haematology, ...) Similar multidisciplinary theoretical contexts (e.g., modelling, analysis, description, visualization, complex systems, ...) Similar multidisciplinary medical issues and questions (e.g., clinical practice, decision making, informatics, ...) Uniquely explores role of interdisciplinary exchange in the development and expansion of medical theory Timely and insightful essays on the growth and development of medical theories from some of the world's top clinicians and medical researchers, including Werner Arber, Frank Vertosick, and David Weatherall Assembles diverse perspectives on medicine and physiology from biology, statistics, ethics, computer science, philosophy, history Uniquely illuminates the social and historical processes through which theoretical research translates into clinical practice Reveals the growing role of technology, especially computational modelling, in changing the nature of Western medicine