Mucosal Immunology of Acute Bacterial Pneumonia [recurso electrónico] $c

In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting __Staphylococus aureus__ (including MRSA), __Streptococcus pneumoniae__ and __Klebsiella pneumoniae__. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic. Front Matter....Pages i-x Alveolar Macrophages....Pages 1-48 Lung Dendritic Cells and Pulmonary Defence Mechanisms to Bacteria....Pages 49-66 CD4 T-Cell Immunity in the Lung....Pages 67-82 Neutrophils in Acute Bacterial Pneumonia....Pages 83-124 Toll-Like Receptors in the Airway Epithelium....Pages 125-138 Type I Interferon Responses to Airway Pathogens....Pages 139-158 Transcriptional Signaling Hubs in Epithelial Cells During Pneumonia....Pages 159-183 Innate Immune Responses in Ventilator-Associated Pneumonia....Pages 185-212 Streptococcus pneumoniae: The Prototype of Lung Responses in Pneumonia....Pages 213-238 Staphylococcus aureus Infection in the Respiratory Tract....Pages 239-258 Pseudomonas aeruginosa and Mucosal Defenses in the Lung....Pages 259-269 Back Matter....Pages 271-277