Mosaicism in Human Skin : Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia

Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis Front Matter....Pages i-xiii Introduction....Pages 1-2 Front Matter....Pages 3-3 Mosaicism as a Biological Concept....Pages 5-12 Two Major Categories of Mosaicism....Pages 13-37 Relationship Between Hypomorphic Alleles and Mosaicism of Lethal Mutations....Pages 39-42 Front Matter....Pages 43-43 Six Archetypical Patterns....Pages 45-61 Less Well Defined or So Far Unclassifiable Patterns....Pages 63-65 Front Matter....Pages 67-67 Nevi....Pages 69-108 Didymotic Skin Disorders....Pages 109-114 Other Binary Genodermatoses, Including “Pseudodidymosis”....Pages 115-120 Mosaic Manifestation of Autosomal Dominant Skin Disorders....Pages 121-175 Revertant Mosaicism....Pages 177-181 Nevoid Skin Disorders....Pages 183-219 A Note on Neoplastic Skin Lesions....Pages 221-222 Back Matter....Pages 223-229 Rudolf Happle. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.