Monoclonal antibodies, probes for the study of autoimmunity and immunodeficiency [recurso electrónico

Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency focuses on the research/studies using monoclonal antibodies in two major classes of diseases, which are autoimmunity and immunodeficiency. The book comprises of 14 chapters; each is written in detail and includes studies using monoclonal antibodies of the pathogenesis and treatment of various types of diseases of disordered immunity. The first chapter presents an overview of the use of monoclonal antibodies in the study of autoimmunity and immunodeficiency. The following chapters focus on other monoclonal reagents and their uses and applications to different diseases. The last four chapters discuss specific classic endocrine diseases in reference to discoveries regarding the beginning of autoimmune mechanisms and pathophysiology. Because the book is technically written, students with background in biology, microbiology, and biochemistry are most likely the target audience of this book. Other parties in the fields of immunology, clinical medicine, pathology, and physiology will also find this book a good reference material. Content: Front Matter , Page iii Copyright , Page iv Contributors , Pages xi-xiii Preface , Pages xv-xvii Chapter 1 - Use of Monoclonal Antibodies in the Study of Autoimmunity and Immunodeficiency , Pages 1-19 , Chikao Morimoto, Stuart F. Schlossman, Ellis L. Reinherz Chapter 2 - Monoclonal Antilymphocyte Antibodies: Probes for the Study of the Regulation of Hematopoiesis and Potential Clinical Applications , Pages 21-46 , Beverly Torok-Storb, Paul J. Martin, John A. Hansen Chapter 3 - Use of Monoclonal Antibodies to Identify Cell-Surface Antigens of Human Neuroendocrine Thymic Epithelium , Pages 47-65 , Barton F. Haynes, George S. Eisenbarth Chapter 4 - Role of Prethymic and Intrathymic Elements in the Induction of T Cell Tolerance to Allogeneic Determinants: The Thymus Is Not Sufficient to Prevent Autoreactivity , Pages 67-81 , Philip J. Morrissey, Alfred Singer Chapter 5 - Studies of Patients with Severe Cellular and Humoral Immunodeficiency Diseases Using Monoclonal Antibodies , Pages 83-95 , Rebecca H. Buckley Chapter 6 - The Use of Monoclonal Antibodies to Characterize Human Natural Killer Cell Ontogeny and Function , Pages 97-113 , Toru Abo, Charles M. Balch Chapter 7 - Utilization of Monoclonal Antibodies in the Study of Cell-Surface Antigens on Human B Lymphocytes , Pages 115-130 , Tucker W. LeBien, John H. Kersey Chapter 8 - Establishment of Human—Human and Human—Mouse B Cell Hybrids and Their Use in the Study of B Cell Activation , Pages 131-151 , H. Clifford Lane, Anthony S. Fauci Chapter 9 - Murine Hybridomas Producing Autoantibodies from MRL Mice , Pages 153-172 , D.S. Pisetsky Chapter 10 - Dual Recognition by Coupled Receptors in a Model of T Lymphocyte Differentiation , Pages 173-196 , Robert L. Evans, Edgar G. Engleman Chapter 11 - Type I Diabetes: Autoimmunity and Immunodeficiency , Pages 197-219 , George S. Eisenbarth, Richard Jackson, S. Srikanta Chapter 12 - Autoimmune Thyroid Disease Studied with Monoclonal Antibodies to the Thyrotropin Receptor , Pages 221-258 , L.D. Kohn, E. Yavin, Z. Yavin, P. Laccetti, P. Vitti, E. Grollman, W. Valente Chapter 13 - Use of Monoclonal Antibodies in the Study of Myasthenia Gravis , Pages 259-296 , Jon Lindstrom Chapter 14 - Peripheral T Cell Circulatory Kinetics and Intrathymic T Cell Differentiation in Myasthenia Gravis , Pages 297-313 , Elizabeth A. Harden, Barton F. Haynes Index , Pages 315-318