Monoclonal Antibodies in Cancer (Contemporary Biomedicine, 6)

This Represents The Third Volume In A Series On Cancer Markers Pub Lished By The Humana Press. The First Volume, Published In 1980, Stressed The Relationship Of Development And Cancer As Reflected In The Production Of Markers By Cancer That Are Also Produced By Normal Cells During Fetal Development. The Concept That Cancer Represents A Problem Of Differentiation Was Introduced By Barry Pierce In Describing Differenti Ation Of Teratocarcinomas. Highlighted Were Lymphocyte Markers, Alphafetoprotein, Carcinoembryonic Antigen, Ectopic Hormones, Enzymes And Isozymes, Pregnancy Proteins, And Fibronectin. The Second Volume, Published In 1982 And Coedited With Britta Wahren, Focused On The Diagnostic Use Of Oncological Markers In Human Cancers, Which Were Systematically Treated On An Organ By Organ Basis. At That Time, The Application Of Monoclonal Antibodies To The Identification Of Cancer Markers Was Still In A Very Preliminary Stage. A General Introduc Tion To Monoclonal Antibodies To Human Tumor Antigens Was Given There By William Raschke, And Other Authors Included Coverage Of Those Mark Ers Then Detectable By Monoclonal Antibodies In Their Chapters. References -- 14 Monoclonal Antibodies to Renal Cancer Markers -- 1. Introduction -- 2. Mab S4 -- 3. Mab S22 -- 4. Mab S23 -- 5. Mab S6 -- 6. Use as Markers of Proximal Tubular Cells -- 7. Ability to Discriminate Renal from Nonrenal Cancers -- 8. Subclassification of Renal Cancer -- 8.1. gp/20nr -- 8.2. Subclassification of gp120nr+ Renal Cancers -- 9. Correlation of Antigenic Phenotypes and Clinical Parameters -- 10. Summary -- References -- 15 Immunochemistry of Human Teratocarcinoma Stem Cells -- 1. Introduction -- 2. Stem Cells of Human Teratocarcinomas -- 2.1. Human Embryonal Carcinoma Cells -- 2.2. Surface Markers of Human EC Cells -- 2.3. Intermediate Filaments -- 3. Markers of Differentiation -- 3.1. The Nature of Differentiation -- 3.2. The Disappearance of EC Cell Markers -- 3.3. The Appearance of New Cell Markers -- 4. Conclusions -- References -- 16 Use of Monoclonal Antibodies in Neurobiology and Neurooncology -- 1. Introduction -- 2. Markers of Central and Peripheral Nervous System (PNS) Tumors Defined by Mabs -- 2.1. Biochemically Defined Markers -- 2.2. Shared Nervous System--Lymphoid Cell Markers -- 2.3. Shared Neuroectodermal--Oncofetal Markers -- 2.4. Putative Tumor-Restricted Markers -- 2.5. Markers of Interest Defined in Animal Model Systems -- 3. Current and Prospective Use of Marker-Mab Systems -- 3.1. The Problem of Antibody Localization and Delivery -- 3.2. The Problem of Antigenic Heterogeneity -- 3.3. Current Use of Single Marker--Mab Systems -- 3.4. The Use of Mab Panels -- 4. Summary and Prospects -- References -- 17 Human Monoclonal Antibodies: Humoral Immune Response in Patients with Cancer -- 1. Introduction -- 1.1. Serological Evidence of Tumor Immunity in Humans -- 1.2. Clinical Evidence of Tumor Immunity in Humans -- 1.3. In Vivo Applications of Human Monoclonal Antibodies -- 2. Approaches to the Generation of Human Monoclonal Antibodies -- 2.1. Immortalization of B Lymphocytes by Epstein-Barr Virus -- 2.2. Strategies Using the Hybridoma Technology -- 3. Further Experim Front Matter....Pages i-xviii Monoclonal Antibody Defined Antigens on Animal Tumors....Pages 1-17 Monoclonal Carcinoembryonic Antigen Antibodies....Pages 19-40 Monoclonal Antibodies to Alphafetoprotein and Regulation of AFP Gene Expression....Pages 41-63 Human Chorionic Gonadotropin Detection with Monoclonal Antibodies....Pages 65-95 Products of the Major Histocompatibility Complex on Tumor Cells....Pages 97-120 Monoclonal Antibodies....Pages 121-145 Antigenic Markers on Normal and Malignant B Cells....Pages 147-166 Nonlymphoblastic Leukemia-Associated Antigens Identified by Monoclonal Antibodies....Pages 167-203 Monoclonal Antibodies as Probes for the Molecular Structure and Biological Function of Melanoma-Associated Antigens....Pages 205-228 Lung Cancer Markers as Detected by Monoclonal Antibodies....Pages 229-246 Human Breast Cancer Markers Defined by Monoclonal Antibodies....Pages 247-277 Antigens of Normal and Malignant Human Exocrine Pancreatic Cells....Pages 279-308 Monoclonal Antibodies to Human Prostate Cancer-Related Antigens....Pages 309-324 Monoclonal Antibodies to Renal Cancer Markers....Pages 325-338 Immunochemistry of Human Teratocarcinoma Stem Cells....Pages 339-364 Use of Monoclonal Antibodies in Neurobiology and Neurooncology....Pages 365-397 Human Monoclonal Antibodies....Pages 399-422 Back Matter....Pages 423-428