Monoclonal Antibodies: Cytokines and Arthritis, Mediators of Inflammation and Therapy (Inflammatory Disease and Therapy)

Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of Cover......Page 1 Half Title......Page 2 Series Page......Page 3 Title Page......Page 4 Copyright Page......Page 5 Dedication......Page 6 Series Introduction......Page 8 Preface......Page 10 Table of Contents......Page 12 1. Monoclonal Antibodies: New Horizons in the Treatment of Human Autoimmune Disease......Page 20 2. Therapeutic Application of Monoclonal Antibodies in the Rheumatic Diseases......Page 30 3. Treatment of Patients with Rheumatoid Arthritis with Anti-CD4 Monoclonal Antibodies......Page 56 4. Human Monoclonal Autoantibodies......Page 76 5. Biologic Therapies for Rheumatoid Arthritis: Concepts from Considerations on Pathogenesis......Page 94 6. Cellular and Molecular Interactions in the Induction of Inflammation in Rheumatic Diseases......Page 120 7. Interleukin-1 Inhibitors and Their Significance in Rheumatoid Arthritis......Page 152 8. Interleukins and Metalloproteinases in Arthritis......Page 192 9. T Cell Cytokines as Immunomodulators of Arthritis Disease Pathology......Page 218 10. Induction and Regulation of Arthritis by T Cell-Derived Collagen Binding Proteins......Page 244 11. Experimental Arthritis: Importance of T Cells and Antigen Mimicry in Chronicity and Treatment......Page 256 12. A Mycobacterial 65 kd Heat-Shock Protein and T Cells in Experimental Arthritis: Possibilities for Immunotherapy......Page 272 13. Immunotherapy of Collagen-Induced Arthritis with Anti-la and Anti-IL-2R Antibodies......Page 288 14. Anti-L3T4 Antibody Therapy in Systemic Lupus Erythematosus......Page 308 15. Autoreactive B Cells in Collagen-Induced Arthritis......Page 332 16. Antiproteoglycan Antibodies in Experimental Spondylarthritis......Page 360 17. Reproduction and Regulation of the Autoimmunity That Induces Cartilage Pathology in Experimental Immune Synovitis......Page 376 18. Serum Keratan Sulfate Concentration as a Measure of the Catabolism of Cartilage Proteoglycans......Page 392 19. Cross-Reactive Idiotypes of Rheumatoid Factors in Arthritis and Related Diseases......Page 418 20. Characterization of Rheumatoid Factors Using Monoclonal Anti-idiotypic Reagents......Page 432 21. The Human Anti-DNA Idiotype (16/6 Idiotype)......Page 454 22. Immunoregulation in Systemic Lupus Erythematosus by Idiotypic Network: Possible Future Therapeutic Implications......Page 484 23. Clinical Trial Design and Concepts for Biologic Agents in the Treatment of Rheumatic Diseases......Page 494 Index......Page 526 About the Editor......Page 536