Monoclonal Antibodies and Breast Cancer : Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer San Francisco, California — November 8–9, 1984

Breast cancer, being a disease with very high prevalence in the female population, has permanently attracted the attention of biologists, biochemists, pathologists, surgeons, and oncologists. In the U.S. alone approximately 120,000 new cases are diagnosed and 37,000 deaths a year are recorded as an outcome. Early diagnosis, clear cut prognosis and the hope of new therapeutic approaches has spurred the enthusiasm of researchers, who with the advent of newer methodologies, tried to employ it in different approaches to the breast cancer patient. In spite of the efforts devoted towards the creation of new approaches, reagents and procedures taking advantage of special characteristics of the breast tissue were slow to come. In general, most diagnostic and prognostic techniques were those shared and applied to other carcinomas. In the early seventies we discovered the first sets of antigens associated with breast epithelial tissue both in the mouse and the human. The recognition of such group of molecules, present in the milk fat globule membrane, gave impetus to several studies in these areas. These mammary cell surface antigens proved useful in several diagnostic approaches such as radioimaging, histochemical and serum assay procedures. However, the apparently inherent limitations of polyclonal antibodies reduced the impact of these novel approaches. Front Matter....Pages i-xx Front Matter....Pages 1-1 Immunostaining of Estrogen Receptors in Paraffin Sections of Breast Cancers Using Anti-Estrophilin Monoclonal Antibodies....Pages 3-12 Clinical Studies on Cell Surface Estrogen-Regulated Proteins....Pages 13-27 MAM-6, a Carcinoma Associated Marker: Preliminary Characterisation and Detection in Sera of Breast Cancer Patients....Pages 28-42 Monoclonal Antibodies in the Study of Mammary Development and Neoplasia....Pages 43-59 Monoclonal Antibodies in the Study of Cell Lineage, Differentiation and Malignancy in the Human Breast....Pages 60-79 Studies with Monoclonal Antibodies to Breast Tumors....Pages 80-85 Front Matter....Pages 87-87 Serological Dissection of Human Breast Cancer with Mouse and Human Monoclonal Antibodies....Pages 89-107 Potential Clinical Application of a Monoclonal Antibody to a Tumor Associated Glycoprotein (TAG-72)....Pages 108-118 Immunocytochmistry for the Selection of Hybridomas and the Characterization of Monoclonal Antibodies: Problems, Solutions and Suggestions....Pages 119-133 Effector Cells in ADCC with Anti-Breast Cancer Monoclonal Antibodies....Pages 134-149 Front Matter....Pages 151-151 Use of Monoclonal Antibodies for Breast Cancer Diagnosis and Prognosis....Pages 153-164 Intracellular and Extracellular Keratins of Human Mammary Epithelial Cells....Pages 165-178 Breast Cancer Antigens Detected with Human Monoclonal Antibodies....Pages 179-189 Monoclonal Antibodies Against Estrogen Receptor: Specificity, Sensitivity and Potential Applications....Pages 190-202 Front Matter....Pages 203-203 Monoclonal Antibodies in the Characterization and Imaging of Human Breast Cancers....Pages 205-217 Use of Monoclonal Antibodies to Detect Metastases of Solid Tumors in Lymph Nodes....Pages 218-232 Detection of Breast Cancer Using the Monoclonal Antibody 3E-1.2....Pages 233-247 An Experimental Model for the Immunological Treatment of Breast Cancer....Pages 248-268 Breast Cancer Immunotoxins....Pages 269-292 Ductal Carcinoma Antigen: Characteristics, Tissue Distribution and Capacity to Represent a Target for Monoclonal Antibody Therapy....Pages 293-302 Front Matter....Pages 203-203 Non-Immunological Factors Affecting the Localization of Monoclonal Antibodies in Xenografts of Human Breast and Colon Tumors....Pages 303-314