Molybdenum and tungsten enzymes. Volume 1., Biochemistry. Volume 2., Bioinorganic chemistry. Volume 3., Spectroscopic and theoretical investigations

There has been enormous progress in our understanding of molybdenum and tungsten enzymes and relevant inorganic complexes of molybdenum and tungsten over the past twenty years. This set of three books provides a timely and comprehensive overview of the field and documents the latest research. Building on the first and second volumes that focussed on biochemistry and bioinorganic chemistry aspects, the third volume focusses on spectroscopic and computational methods that have been applied to both enzymes and model compounds. A particular emphasis is placed on how these important studies have been used to reveal critical components of enzyme mechanisms. This text will be a valuable reference to workers both inside and outside the field, including graduate students and young investigators interested in developing new research programs in this area. Content: Cover Molybdenum and Tungsten Enzymes Spectroscopic and Theoretical Investigations Preface Dedication Contents Chapter 1 -- Spectroscopic and Electronic Structure Studies Probing Mechanism: Introduction and Overview 1.1 Introduction 1.2 Overview 1.2.1 Pyranopterin Molybdenum Enzymes 1.2.2 Nitrogenase 1.3 Summary Acknowledgements References Chapter 2 -- Spectroscopic and Electronic Structure Studies of Mo Model Compounds and Enzymes 2.1 Introduction and Scope 2.2 The Pyranopterin Dithiolene and the Molybdenum Cofactor (Moco) 2.2.1 General Background. 2.2.2 Model Studies Defining the Mo-Dithiolene Interaction in Moco2.2.3 Conformational Studies of the PDT 2.2.4 Spectroscopic Studies of the PDT 2.3 Sulfite Oxidase 2.3.1 Active Site Structure and General Reaction Catalyzed 2.3.2 Select Spectroscopic Studies of Model Systems 2.3.3 Spectroscopic Studies of SO and SO-Type Enzymes 2.3.4 Active Site Electronic Structure Contributions to Reactivity 2.4 Xanthine Oxidoreductase (XOR) 2.4.1 Active Site Structure and General Reaction Catalyzed 2.4.2 Select Spectroscopic Studies of Model Systems 2.4.3 Spectroscopic Studies of XOR. 2.4.4 Active Site Electronic Structure Contributions to Reactivity2.5 Carbon Monoxide Dehydrogenase 2.5.1 Active Site Structure and General Reaction Catalyzed 2.5.2 EPR Spectroscopic Studies of a Key Model System 2.5.3 Spectroscopic Studies of CODH 2.5.4 Active Site Electronic Structure Contributions to Reactivity 2.6 Dimethylsulfoxide (DMSO) Reductase 2.6.1 Active Site Structure and General Reaction Catalyzed 2.6.2 Select Spectroscopic Studies of Model Systems 2.6.3 Spectroscopic Studies of DMSOR 2.6.4 Active Site Electronic Structure Contributions to Reactivity. 2.7 MOSC Family Enzymes2.7.1 Active Site Structure and General Reaction Catalyzed 2.7.2 Spectroscopic Studies of MOSC Proteins 2.7.3 Active Site Electronic Structure Contributions to Reactivity 2.8 Perspective Acknowledgements References Chapter 3 -- Electron Paramagnetic Resonance Studies of Molybdenum Enzymes 3.1 Introduction 3.2 Principles of EPR Techniques and Application to Mo/W Enzymes 3.2.1 Basis of EPR Spectroscopy 3.2.2 EPR Properties of Mo and W Enzymes 3.3 g-Tensor Analysis for Mo/W Enzymes 3.3.1 g-Tensor for a d1 Configuration. 3.3.2 Magneto-Structural Correlations in the Mo-Enzyme Family3.3.3 g-Tensor Analysis of Mo-bisPGD Active Site: Influence of the Protein Ligands 3.3.4 The g-Tensor of Mo(V)-monoPPT: The Case Study of the Sulfite Oxidase Family 3.3.5 g-Tensor and Substrate Binding: The Xanthine Oxidase Family 3.3.6 g-Tensor Calculation: Ab-initio and DFT Methods 3.3.7 g-Tensor of W(v) Species in Tungsten Enzymes 3.4 Detection and Analysis of Hyperfine Couplings to Mo/W(v) Species 3.4.1 Hyperfine Coupling to the Metal Ion 3.4.1.1 95,97Mo Hyperfine and Nuclear Quadrupole Tensors.

There has been enormous progress in our understanding of molybdenum and tungsten enzymes and relevant inorganic complexes of molybdenum and tungsten over the past twenty years. This set of three books provides a timely and comprehensive overview of the field and documents the latest research.
Building on the first and second volumes that focussed on biochemistry and bioinorganic chemistry aspects, the third volume focusses on spectroscopic and computational methods that have been applied to both enzymes and model compounds. A particular emphasis is placed on how these important studies have been used to reveal critical components of enzyme mechanisms.
This text will be a valuable reference to workers both inside and outside the field, including graduate students and young investigators interested in developing new research programs in this area.

This book covers the bioinorganic chemistry of molybdenum and tungsten enzymes and the physicochemical methods that are used to investigate their structure and function. Editors: Russ Hille, Carola Schulzke, Martin L. Kirk. Includes Index. Mode Of Access: World Wide Web.