Molecules to Medicine with MTOR: Translating Critical Pathways of the Mammalian Target of Rapamycin into Novel Therapeutic Strategies

__Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies__ is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.* Covers the role of mTOR by internationally recognized expert contributors in the field. * Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. * Includes analysis of the role of mTOR and in both health and disease. * Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings. Content: Front-matter,Copyright,List of Contributors,About the Editor,PrefaceEntitled to full textSection I: mTOR in Cellular Development, Proliferation, and SurvivalChapter 1 - Novel Stem Cell Strategies with mTOR, Pages 3-22 Chapter 2 - mTOR: The Master Regulator of Conceptus Development in Response to Uterine Histotroph During Pregnancy in Ungulates, Pages 23-35, Xiaoqiu Wang, Guoyao Wu, Fuller W. Bazer Chapter 3 - mTORC1 in the Control of Myogenesis and Adult Skeletal Muscle Mass, Pages 37-56, Marita A. Wallace, David C. Hughes, Keith Baar Chapter 4 - mTOR: A Critical Mediator of Articular Cartilage Homeostasis, Pages 57-68, Akihiro Nakamura, Mohit Kapoor Chapter 5 - The Role of mTOR, Autophagy, Apoptosis, and Oxidative Stress During Toxic Metal Injury, Pages 69-81, Sarmishtha Chatterjee, Chayan Munshi, Shelley Bhattacharya Chapter 6 - The mTOR Signaling Pathway in Neurodegenerative Diseases, Pages 85-104, Arnaud Francois, Julie Verite, Agnès Rioux Bilan, Thierry Janet, Frédéric Calon, Bernard Fauconneau, Marc Paccalin, Guylène Page Chapter 7 - mTOR: Exploring a New Potential Therapeutic Target for Stroke, Pages 105-122, Mar Castellanos, Carme Gubern, Elisabet Kadar Chapter 8 - mTOR Signaling in Epilepsy and Epileptogenesis: Preclinical and Clinical Studies, Pages 123-142, Antonio Leo, Andrew Constanti, Antonietta Coppola, Rita Citraro, Giovambattista De Sarro, Emilio Russo Chapter 9 - mTOR, Autophagy, Aminoacidopathies, and Human Genetic Disorders, Pages 143-166, Garrett R. Ainslie, K. Michael Gibson, Kara R. Vogel Chapter 10 - mTOR Involvement in the Mechanisms of Memory: An Overview of Animal Studies, Pages 169-184, Maria Grazia Giovannini, Daniele Lana Chapter 11 - Mammalian Target of Rapamycin (mTOR), Aging, Neuroscience, and Their Association with Aging-Related Diseases, Pages 185-203, Ergul Dilan Celebi-Birand, Elif Tugce Karoglu, Fusun Doldur-Balli, Michelle M. Adams Chapter 12 - The Role of mTOR in Mood Disorders Pathophysiology and Treatment, Pages 205-214, Gislaine Z. Réus, Meagan R. Pitcher, Camila O. Arent, João Quevedo Chapter 13 - mTOR and Drugs of Abuse, Pages 215-226, Jacob T. Beckley, Dorit Ron Chapter 14 - mTOR as a Modulator of Metabolite Sensing Relevant to Angiogenesis, Pages 229-243, S.J. Soumya, A.P. Athira, S. Binu, P.R. Sudhakaran Chapter 15 - Role of mTOR Signaling in Cardioprotection, Pages 245-262, Anindita Das, Rakesh C. Kukreja Chapter 16 - Role of Mammalian Target of Rapamycin (mTOR) in Cardiac Homeostasis in Metabolic Disorders, Pages 263-274, Xiangwei Liu, Jun Ren Chapter 17 - Roles of Mechanistic Target of Rapamycin in the Adaptive and Innate Immune Systems, Pages 277-292, Hiroshi Kato, Andras Perl Chapter 18 - The Role of mTOR Inhibitors in Solid Organ Transplantation, Pages 293-315, Greg J. McKenna, Goran B.G. Klintmalm Chapter 19 - mTOR and Neuroinflammation, Pages 317-329, Filipe Palavra, António Francisco Ambrósio, Flávio Reis Chapter 20 - mTOR in Multiple Sclerosis: The Emerging Role in the Regulation of Glial Biology, Pages 331-343, Cinzia Dello Russo, Pierluigi Navarra, Lucia Lisi Chapter 21 - mTOR in Metabolic and Endocrine Disorders, Pages 347-364, Marta M. Swierczynska, Michael N. Hall Chapter 22 - Chronic mTOR Inhibition by Rapamycin and Diabetes: What is the Role of Mitochondria?, Pages 365-378, Liang-Jun Yan, Zhiyou Cai Chapter 23 - mTOR in Diabetic Nephropathy and Retinopathy, Pages 379-393, Rosa Fernandes, Flávio Reis Chapter 24 - Lymphangioleiomyomatosis (LAM): Molecular Insights into mTOR Regulation Lead to Targeted Therapies, Pages 397-415, Wendy K. Steagall, Connie G. Glasgow, Gustavo Pacheco-Rodriguez, Joel Moss Chapter 25 - mTOR Pathway in Renal Cell Carcinoma, Pages 417-428, Matteo Santoni, Francesco Massari Chapter 26 - Metabolic Shunt Pathways, Carcinoma, and mTOR, Pages 429-438, Norisuke Shibuya, Ken-ichi Inoue, Keiichi Kubota Index, Pages 439-454 Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.

• Covers the role of mTOR by internationally recognized expert contributors in the field.
• Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels.
• Includes analysis of the role of mTOR and in both health and disease.
• Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.