Molecular Virology : Molecular and Medical Aspects of Disease-Causing Viruses of Man and Animals

This book was written during a period when the technologies of genetic engineering were being applied to the study of animal viruses and when the organization and function of individual virus genes were being elucidated. This book, which uses human and animal viruses as models, aims to under­ stand the developments in molecular virology during the last 20 years. Al­ though molecular virology could also be taught by means of bacteriophages or plant viruses, the advantage of using animal viruses is in their ability to cause human and animal diseases as well as to transform cells, a primary problem in medicine. For the sake of clarity and convenience, not all the individual contributors to the various aspects of molecular virology were cited in the text. Instead, the reader is referred to review articles or key papers that list the numerous excel­ lent publications that have contributed to clarification of the various molecular processes. Thus the end-of-chapter bibliographies will guide the reader to the publications in which the original contributing authors are quoted. References given under the heading Recommended Reading are intended to assist those interested in pursuing a given subject further. I hope that this book will fulfill the purpose for which it is designed, and I urge readers to contact me if errors are found or updating is required. Front Matter....Pages i-xi Front Matter....Pages 1-1 Steps in the Development of Virus Research....Pages 3-15 Classification of Viruses....Pages 16-21 Molecular Considerations of Virus Replication and Virus-Cell Interactions....Pages 22-31 Genes in Human Cells Determining Virus Susceptibility....Pages 32-34 Front Matter....Pages 35-35 Poxviruses....Pages 39-53 Iridoviruses....Pages 54-58 Herpesviruses....Pages 59-87 Adenoviruses....Pages 88-102 Papovaviruses....Pages 103-121 Hepatitis B Virus....Pages 122-128 Parvoviruses....Pages 131-135 Double-Stranded RNA Viruses Made from Single-Stranded RNA: Reoviruses....Pages 139-143 Single-Stranded RNA Minus Viruses with an Intact Genome: Rhabdoviruses....Pages 144-152 Single-Stranded RNA Minus Viruses with an Intact Genome: Paramyxoviruses....Pages 153-161 Single-Stranded RNA Minus Viruses with a Fragmented Linear Genome: Orthomyxoviruses....Pages 162-174 Single-Stranded RNA Minus Viruses With a Fragmented Linear Genome: Arenaviruses....Pages 175-178 Single-Stranded RNA Minus Viruses with a Fragmented Circular Genome: Bunyaviruses....Pages 179-184 RNA Plus Genome that Serves as Messenger RNA: Picornaviruses....Pages 187-202 RNA Plus Genome that Serves as Messenger RNA: Togaviruses....Pages 203-215 RNA Plus Genome that Serves as Messenger RNA: Coronaviruses....Pages 216-219 Front Matter....Pages 35-35 Single-Stranded RNA Plus Genomes that Synthesize DNA as Part of their Life Cycle: Retroviruses (RNA Tumor Viruses)....Pages 220-249 Marburg and Ebola Viruses....Pages 253-254 Slow Virus Infections of the CNS....Pages 255-258 Front Matter....Pages 259-259 Immunization Against Virus Diseases....Pages 261-272 Viruses as Selective Forces in Nature: Epidemics....Pages 273-276 Antiviral Drugs and Chemotherapy of Viral Diseases of Man....Pages 277-305 Laboratory Diagnosis of Disease-Causing Viruses....Pages 306-312 Viruses and Human Cancer....Pages 313-316 Social, Economic, and Juridical Aspects of Virus Diseases....Pages 317-320 Front Matter....Pages 321-321 Summary....Pages 323-332 Back Matter....Pages 333-344