Molecular Theory of Evolution : Outline of a Physico-Chemical Theory of the Origin of Life

The subject of this book is the physico-chemical theory of the origin of life. Although this theory is still in statu nascendi, it has been developed in recent years to the point where a coherent presentation is possible. The book is intended as an introductory text for students of physics, chemistry or biology. This interdisciplinary aim has necessitated a choice of material based on the lowest common denominator of physicists and biologists. In particular, the predominantly mathematical and biological sections have been presented at the most elementary l.evel possible. The less mathematically inclined reader can omit Sections (5.3)-(5.5), (5.7)-(5.10), (6.2), (6.3), (9.1)-(9.3), (12.1) and (13.3) without losing the overall view. For critical reading of the manuscript, for discussions and for many useful suggestions I wish to thank M. Eigen (Gottingen), w.e. Gardiner (Austin), D. Porschke (Gottingen), P. Schuster (Vienna), P.R. Wills (Auckland) and P. Woolley (Berlin). The translation of the original, German manuscript into English was kindly undertaken by Paul Woolley. During this and subsequent stages of revision he introduced a great many improvements in the text and the presentation of material. My particular thanks are due to him for his decisive contribution to this book. Last of all I wish to thank Ingeborg Lechten for typing the text in its various stages of evolution. The completion of this book is largely to be attributed to her patience and efficiency. Front Matter....Pages I-IX Introduction....Pages 1-4 Front Matter....Pages 5-5 Definition of Living Systems....Pages 7-10 Structure and Function of Biological Macromolecules....Pages 11-28 The Information Problem....Pages 29-34 Front Matter....Pages 35-35 A Model System for Molecular Self-Organization....Pages 37-39 Deterministic Theory of Selection....Pages 40-102 Stochastic Theory of Selection....Pages 103-125 Front Matter....Pages 127-127 The Information Threshold....Pages 129-153 Self-Organization in Macromolecular Networks....Pages 154-174 Information-Integrating Mechanisms....Pages 175-209 The Origin of the Genetic Code....Pages 210-227 The Evolution of Hypercycles....Pages 228-242 Front Matter....Pages 243-243 Systems under Idealized Boundary Conditions....Pages 245-256 Evolution in the Test-Tube....Pages 257-278 Conclusions: The Logic of the Origin of Life....Pages 279-283 Back Matter....Pages 285-324