Molecular Pathology and the Dynamics of Disease

__Molecular Pathology and the Dynamics of Disease__ bridges the basic science of, and primary clinical literature on, human disease. Topics covered include several major disease areas, such as inflammation and host response, vascular disease, obesity, weight regulation and appetite, cancer biology, drug development, and gene- and cell-based therapeutics that are all presented in a way that emphasizes the interplay between clinical care and investigation. As new technologies and techniques are constantly changing and laboratory scientists plays a critical role in validating data used by clinicians in diagnosing patients, this book provides a timely guide that includes a clinical, research and theory perspective. * Assimilates theoretical knowledge with practical lab work * Provides a needed clinical perspective, along with research and theory * Highlights the impact of basic science on the practice of medicine Content: Intro Title page Table of Contents Copyright Dedication Preface Chapter 1. Molecular Pathology Introduction and Research Review Abstract Pathogenesis Overview and Review Incubation Period Multiplication in Target Organs Shedding of Virus Congenital Infections NK Cells in Hepatitis C Virus Infection Conclusions References Further Reading Chapter 2. Challenges in Molecular Pathology Abstract General Overview of Molecular Applications in Pathology Technical Obstacles for the Molecular Diagnostic Industry and in the Pathology Laboratory Technological Challenges in Molecular AssaysMutation Detection in Precision Medicine Detection of Chromosomal Rearrangements: In Situ Hybridization Validation of Comprehensive Molecular Assays Quality Management Program References Further Reading Chapter 3. Review of Clinical Human Medical Genetics Abstract Deoxyribonucleic Acid (DNA) Context of Clinical Human Genetics References Further Reading Chapter 4. Molecular Medicine in Action Abstract Grossing Procedures Specimen Adequacy Specimen Collection Instructions Immunohistochemistry and HPV In Situ Procedures Kwik-Diff StainingNon-GYN Staining Gram Stain Method: Hucker's Modification Gomori's Trichrome Stain Acid-Fast Bacilli Stain for Mycobacteria Destaining Procedure Chapter 5. Mechanisms of Disease Abstract NK Cells in CMV Infection NK Cells in HIV-1 Infection References Further Reading Index

Molecular Pathology and the Dynamics of Disease bridges the basic science of, and primary clinical literature on, human disease. Topics covered include several major disease areas, such as inflammation and host response, vascular disease, obesity, weight regulation and appetite, cancer biology, drug development, and gene- and cell-based therapeutics that are all presented in a way that emphasizes the interplay between clinical care and investigation. As new technologies and techniques are constantly changing and laboratory scientists plays a critical role in validating data used by clinicians in diagnosing patients, this book provides a timely guide that includes a clinical, research and theory perspective.

• Assimilates theoretical knowledge with practical lab work
• Provides a needed clinical perspective, along with research and theory
• Highlights the impact of basic science on the practice of medicine