میکروبیولوژی پزشکی مولکولی. جلد ۲

The molecular age has brought about dramatic changes in medical microbiology, and great leaps in our understanding of the mechanisms of infectious disease. __Molecular Medical Microbiology__ is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource. This timely and authoritative three-volume work is an invaluable reference source of medical bacteriology. Comprising more than 100 chapters, organized into 17 major sections, the scope of this impressive work is wide-ranging. Written by experts in the field, chapters include cutting-edge information, and clinical overviews for each major bacterial group, in addition to the latest updates on vaccine development, molecular technology and diagnostic technology. Topics covered include bacterial structure, cell function, and genetics; mechanisms of pathogenesis and prevention; antibacterial agents; and infections ranging from gastrointestinal to urinary tract, centrtal nervous system, respiratory tract, and more. * The first comprehensive and accessible reference on molecular medical microbiology * Full color presentation througout * In-depth discussion of individual pathogenic bacteria in a system-oriented approach * Includes a clinical overview for each major bacterial group * Presents the latest information on vaccine development, molecular technology, and diagnostic technology * More than 100 chapters covering all major groups of bacteria * Written by an international panel of authors who are experts in their respective disciplines Content: Front-matter, Pages i,iii Copyright, Page iv List of Contributors, Pages xiii-xviii, Ernesto Abel-Santos, Soman N. Abraham, Shin-Ichi Aizawa, Michael J. Aldape, David C. Alexander, David G. Allison, Sebastian G.B. Amyes, Burt E. Anderson, Frank J. Anderson, Haike Antelmann, Frank W. Austin, Nieves Ayllón, Fang Bai, Angela Silva Barbosa, Michael R. Barer, Gregory S. Basarab, Blaine L. Beaman, Matthew Beard, Carolyn M. Black, Garry W. Blakely, Patrick Boiron, et al. Preface, Page xix, Yi-Wei Tang Preface to the First Edition, Page xxi, Max Sussman Chapter 1 - Molecular Medical Microbiology – The Expanding Concept, Pages 1-4, Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian R. Poxton, Joseph D. Schwartzman Chapter 2 - Bacterial Ultrastructure, Pages 7-32, Jan A. Hobot Chapter 3 - Bacterial Capsules, Pages 33-53, Zhensong Wen, Jing-Ren Zhang Chapter 4 - Genetics and Biosynthesis of Lipopolysaccharide, Pages 55-89, Miguel A. Valvano Chapter 5 - Teichoic Acids, Lipoteichoic Acids and Other Secondary Cell Wall and Membrane Polysaccharides of Gram-Positive Bacteria, Pages 91-103, Ian R. Poxton Chapter 6 - Peptidoglycan, Pages 105-124, Waldemar Vollmer Chapter 7 - Flagella, Pages 125-146, Shin-Ichi Aizawa Chapter 8 - Pili and Fimbriae of Gram-Negative Bacteria, Pages 147-162, Ender Volkan, Vasilios Kalas, Scott Hultgren Chapter 9 - Endospores, Sporulation and Germination, Pages 163-178, Ernesto Abel-Santos Chapter 10 - Bacterial Growth, Culturability and Viability, Pages 181-199, Michael R. Barer Chapter 11 - Bacterial Energy Metabolism, Pages 201-233, Bruce Ward Chapter 12 - Biofilms, Quorum Sensing and Crosstalk in Medically Important Microbes, Pages 235-247, Jake A. Everett, Kendra P. Rumbaugh Chapter 13 - Oxidative Stress Responses and Redox Signalling Mechanisms in Bacillus subtilis and Staphylococcus aureus, Pages 249-274, Haike Antelmann Chapter 14 - Bacterial Proteomics in the Study of Virulence: An Overview, Pages 277-290, David G.E. Smith, Robert J. Goldstone, Neil F. Inglis, Eleanor Watson Chapter 15 - Mechanisms of Horizontal Gene Transfer and DNA Recombination, Pages 291-302, Garry W. Blakely Chapter 16 - Pathogenicity Islands: Origins, Structure, and Roles in Bacterial Pathogenesis, Pages 303-314, Kelly N. Hallstrom, Beth A. McCormick Chapter 17 - Coordination of Bacterial Virulence Gene Expression, Pages 315-335, Charles J. Dorman Chapter 18 - Towards a Synthesis of Population Genomics and Epidemiology: Next-Generation Sequencing of Bacterial Pathogens, Pages 337-345, Santiago Castillo-Ramirez, Edward J. Feil Chapter 19 - The Human Microbiota and Pathogen Interactions, Pages 347-356, Alan W. Walker Chapter 20 - Bacterial Whole-Genome Determination and Applications, Pages 357-368, Yongqun He Chapter 21 - Molecular Taxonomy, Pages 369-379, David C. Alexander, Paul N. Levett, Christine Y. Turenne Chapter 22 - Principles and Applications of Genomic Diagnostic Techniques, Pages 381-397, Cesar J. Figueroa, Yi-Wei Tang, Ying Taur Chapter 23 - Non-genomic Omic Techniques, Pages 399-406, Yi-Wei Tang Chapter 24 - Adhesion and Colonization, Pages 409-421, Soman N. Abraham, Nathan Sharon, Itzhak Ofek, Joseph D. Schwartzman Chapter 25 - Invasion, Pages 423-448, Shangwei Wu Chapter 26 - Pattern Recognition Receptors and the Innate Immune Network, Pages 449-474, William F. Wade Chapter 27 - Survival Strategies of Extracellular Bacterial Pathogens, Pages 475-489, Robin R. Chamberland, Lars F. Westblade Chapter 28 - Survival Strategies of Intracellular Bacterial Pathogens, Pages 491-515, Robert J. Cain, José A. Vázquez-Boland Chapter 29 - A Phylogenetic Perspective on Molecular Epidemiology, Pages 517-536, Xin Wang, I. King Jordan, Leonard W. Mayer Chapter 30 - Mammalian Antimicrobial Peptides; Defensins and Cathelicidins, Pages 539-565, Julia R. Dorin, Brian J. McHugh, Sarah L. Cox, Donald J. Davidson Chapter 31 - Antimicrobial Phages, Pages 567-581, David R. Harper, Malcolm McConville, Frank J. Anderson, Mark C. Enright Chapter 32 - Modes of Action of Antibacterial Agents, Pages 583-598, David G. Allison, Peter A. Lambert Chapter 33 - Molecular Epidemiology of Antibiotic Resistance in Humans and Animals, Pages 599-609, Sebastian G.B. Amyes, Benjamin A. Evans Chapter 34 - Design of Antibacterial Agents, Pages 611-626, Gregory S. Basarab, Ann E. Eakin, Wright W. Nichols Chapter 35 - Vaccines, Pages 627-634, Petra C.F. Oyston Chapter 36 - Disseminated Infections: A Clinical Overview, Pages 637-653, Simon Ellis, Edmund Ong Chapter 37 - Staphylococcus aureus, Pages 655-674, Timothy J. Foster, Joan A. Geoghegan Chapter 38 - Streptococcus pyogenes, Pages 675-716, Mark Reglinski, Shiranee Sriskandan Chapter 39 - The Enterococci, Pages 717-730, Susan R. Heimer, Donald Morrison, Michael S. Gilmore Chapter 40 - Nocardia and Actinomyces, Pages 731-752, Petar Pujic, Blaine L. Beaman, Miora Ravalison, Patrick Boiron, Verónica Rodríguez-Nava Chapter 41 - Pseudomonas aeruginosa, Pages 753-767, Weihui Wu, Yongxin Jin, Fang Bai, Shouguang Jin Chapter 42 - Burkholderia pseudomallei and Burkholderia mallei, Pages 769-791, Tim J.J. Inglis, Adam J. Merritt Chapter 43 - Coagulase-Negative Staphylococci and Their Role in Infection, Pages 793-810, Curtis G. Gemmell, Sue Lang Chapter 44 - Molecular Pathogenesis of Infective Endocarditis, Pages 811-822, Cassandra L. Brinkman, Robin Patel Chapter 45 - Skin and Soft Tissue Infections: A Clinical Overview, Pages 825-835, Zuotao Zhao, Lin Ma Chapter 46 - Propionibacteria and Disease, Pages 837-858, Andrew McDowell, István Nagy Chapter 47 - Erysipelothrix rhusiopathiae, Pages 859-872, Qinning Wang, Thomas V. Riley Chapter 48 - Anaerobic Infections: A Clinical Overview, Pages 875-897, Hannah M. Wexler Chapter 49 - Clostridium perfringens and Other Life-Threatening Clostridial Soft Tissue Infections, Pages 899-907, Amy E. Bryant, Michael J. Aldape, Dennis L. Stevens Chapter 50 - Clostridium tetani and Tetanus Toxin: A Therapeutic Approach with a Promising Molecule – Fragment C of Tetanus Toxin, Pages 909-916, Ana Cristina Calvo, Rosario Osta Chapter 51 - Bacteroides, Pages 917-944, Sheila Patrick Chapter 52 - Dental Caries, Pages 945-955, Richard J. Lamont, Paul G. Egland Chapter 53 - Bacteriology of Periodontal Diseases, Pages 957-968, Eija Könönen, Purnima S. Kumar Chapter 54 - Toxin-Associated Gastrointestinal Disease: A Clinical Overview, Pages 971-977, Dongyou Liu Chapter 55 - Enterotoxin-Producing Staphylococcus aureus, Pages 979-995, Dongyou Liu Chapter 56 - Enteric Toxins of Clostridium perfringens: Beta Toxin, TpeL, Epsilon Toxin and Iota Toxin, Pages 997-1013, Masahiro Nagahama, Masataka Oda, Hideaki Tsuge, Keiko Kobayashi Chapter 57 - Clostridium botulinum and Associated Neurotoxins, Pages 1015-1029, Matthew Beard, John A. Chaddock Chapter 58 - Clostridium difficile – A Pathogen on the Move, Pages 1031-1040, Alexandra Faulds-Pain, Melissa J. Martin, Brendan W. Wren Chapter 59 - The Bacillus cereus Group, Pages 1041-1078, Nalini Ramarao, Didier Lereclus, Alexei Sorokin Chapter 60 - Vibrio cholerae, Pages 1079-1098, Ana A. Weil, Jason B. Harris Chapter 61 - Aeromonas, Pages 1099-1110, Dongyou Liu Chapter 62 - Plesiomonas, Pages 1111-1123, Jesús A. Santos, José-María Rodríguez-Calleja, Andrés Otero, María-Luisa García-López Chapter 63 - Superficial Gastrointestinal Infections: A Clinical Overview, Pages 1127-1131, Dongyou Liu Chapter 64 - Diarrhoeagenic Escherichia coli, Pages 1133-1146, Dongyou Liu Chapter 65 - Shigella and Shigellosis: Genetics, Epidemiology and Pathogenesis, Pages 1147-1168, Sophie Octavia, Ruiting Lan Chapter 66 - Vibrio parahaemolyticus and Vibrio vulnificus, Pages 1169-1186, James D. Oliver, Jessica L. Jones Chapter 67 - Campylobacter, Pages 1187-1236, Nadeem O. Kaakoush, Hazel M. Mitchell, Si Ming Man Chapter 68 - Helicobacter pylori, Pages 1237-1258, Brunella Posteraro, Patrizia Posteraro, Maurizio Sanguinetti Chapter 69 - Tropheryma whipplei, Pages 1259-1266, Dongyou Liu, Frank W. Austin Chapter 70 - Systemic Gastrointestinal Infections: A Clinical Overview, Pages 1269-1273, Dongyou Liu Chapter 71 - Salmonella Typhi and Salmonella Paratyphi A, Pages 1275-1306, Kenneth E. Sanderson, Shu-Lin Liu, Le Tang, Randal N. Johnston Chapter 72 - Non-typhoidal Salmonella Interactions with Host Cells, Pages 1307-1317, Renato L. Santos Chapter 73 - Yersinia enterocolitica, Pages 1319-1344, Alexander Rakin, Debora Garzetti, Hicham Bouabe, Lisa D. Sprague Chapter 74 - Listeria monocytogenes, Pages 1345-1361, P. David McMullen, Nancy E. Freitag Chapter 75 - Urinary Tract Infections: A Clinical Overview, Pages 1365-1371, Max Sussman Chapter 76 - Escherichia coli in Urinary Tract Infections, Pages 1373-1387, Patrick D. Olson, Sheryl S. Justice, David A. Hunstad Chapter 77 - Urinary Tract Infections Caused by Proteus mirabilis, Pages 1389-1400, Sandra M. Fox-Moon, Mark E. Shirtliff Chapter 78 - Bacterial Sexually Transmitted Infections (STIs): A Clinical Overview, Pages 1403-1420, Joseph U. Igietseme, Yusuf Omosun, Carolyn M. Black Chapter 79 - Uncultivable Pathogenic Treponemes, Pages 1421-1436, David Šmajs, Michal Strouhal Chapter 80 - Haemophilus ducreyi: Chancroid, Pages 1437-1447, Tricia L. Humphreys, Diane M. Janowicz Chapter 81 - Chlamydia trachomatis, Pages 1449-1469, Huizhou Fan, Guangming Zhong Chapter 82 - Neisseria gonorrhoeae, Pages 1471-1485, Gordon G. McSheffrey, Scott D. Gray-Owen Chapter 83 - Bacterial Vaginosis-Associated Bacteria, Pages 1487-1496, Elisa Margolis, David N. Fredricks Chapter 84 - Respiratory Tract Infections: A Clinical Approach, Pages 1499-1506, Kurt D. Reed Chapter 85 - Bordetella pertussis, Pages 1507-1527, Nicole Guiso Chapter 86 - Streptococcus pneumoniae, Pages 1529-1546, Mario Ramirez Chapter 87 - Klebsiella pneumoniae and Pseudomonas aeruginosa, Pages 1547-1564, Min Wu, Xuefeng Li Chapter 88 - Moraxella catarrhalis, Pages 1565-1586, Suzanne J.C. Verhaegh, Viveka Schaar, Yu Ching Su, Kristian Riesbeck, John P. Hays Chapter 89 - Mycoplasmas and Ureaplasmas of Humans, Pages 1587-1609, Ken B. Waites, Li Xiao Chapter 90 - Legionella, Pages 1611-1625, Elizabeth J. Nazarian, Magdia De Jesus, Kimberlee A. Musser Chapter 91 - Corynebacterium spp. as Established and Emerging Respiratory Pathogens, Pages 1627-1633, Amanda T. Harrington, Jill E. Clarridge III, Steven D. Mahlen Chapter 92 - Mycobacterium tuberculosis, Pages 1637-1653, Elizabeth A. Talbot, Brittany J. Raffa Chapter 93 - Mycobacterium leprae, Pages 1655-1668, Thomas P. Gillis Chapter 94 - The Mycobacterium avium Complex and Slowly Growing Mycobacteria, Pages 1669-1678, Joseph O. Falkinham Chapter 95 - Rapidly Growing Mycobacteria, Pages 1679-1690, Patricia J. Simner, Reeti Khare, Nancy L. Wengenack Chapter 96 - Bacterial Infections of the Central Nervous System: Pathogenesis, Pathophysiology and Clinical Aspects, Pages 1693-1707, Jeffrey M. Tessier, W. Michael Scheld Chapter 97 - Haemophilus influenzae, Pages 1709-1728, Nicola J. High, Feinan Fan, Joseph D. Schwartzman Chapter 98 - Neisseria meningitidis, Pages 1729-1750, Jonathan E. Schmitz, Charles W. Stratton Chapter 99 - Streptococcus agalactiae (Group B Streptococci), Pages 1751-1767, Prescilla Emy Nagao Chapter 100 - Bacterial Zoonoses: An Overview, Pages 1771-1780, Sally J. Cutler Chapter 101 - Brucella, Pages 1781-1788, Dongyou Liu Chapter 102 - Bacillus anthracis and Other Bacillus Species, Pages 1789-1844, Christopher K. Cote, Jared D. Heffron, Joel A. Bozue, Susan L. Welkos Chapter 103 - Yersinia pestis, Pages 1845-1865, Robert R. Brubaker Chapter 104 - Borrelia burgdorferi and Other Borrelia Species, Pages 1867-1909, Guiqing Wang Chapter 105 - Bartonella, Pages 1911-1939, Michael F. Minnick, Burt E. Anderson Chapter 106 - Coxiella, Pages 1941-1972, Thomas J. Marrie, Michael F. Minnick, Julien Textoris, Christian Capo, Jean-Louis Mege Chapter 107 - Leptospira and Leptospirosis, Pages 1973-1990, Tatiana Rodrigues Fraga, Eneas Carvalho, Lourdes Isaac, Angela Silva Barbosa Chapter 108 - Francisella, Pages 1991-2009, Anna-Lena Johansson, Laila Noppa, Emelie Näslund Salomonsson, Åke Forsberg Chapter 109 - Ehrlichia, Pages 2011-2032, Nagaraja R. Thirumalapura, David H. Walker Chapter 110 - Anaplasma, Pages 2033-2042, Maiara S. Severo, Joao H.F. Pedra, Nieves Ayllón, Katherine M. Kocan, José de la Fuente Chapter 111 - Rickettsia, Pages 2043-2056, Dongyou Liu Chapter 112 - Orientia, Pages 2057-2096, Daniel H. Paris, Allen L. Richards, Nicholas P.J. Day Index, Pages 2097-2145

The molecular age has brought about dramatic changes in medical microbiology, and great leaps in our understanding of the mechanisms of infectious disease. Molecular Medical Microbiology is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource. This timely and authoritative three-volume work is an invaluable reference source of medical bacteriology. Comprising more than 100 chapters, organized into 17 major sections, the scope of this impressive work is wide-ranging. Written by experts in the field, chapters include cutting-edge information, and clinical overviews for each major bacterial group, in addition to the latest updates on vaccine development, molecular technology and diagnostic technology. Topics covered include bacterial structure, cell function, and genetics; mechanisms of pathogenesis and prevention; antibacterial agents; and infections ranging from gastrointestinal to urinary tract, centrtal nervous system, respiratory tract, and more.

• The first comprehensive and accessible reference on molecular medical microbiology
• Full color presentation througout
• In-depth discussion of individual pathogenic bacteria in a system-oriented approach
• Includes a clinical overview for each major bacterial group
• Presents the latest information on vaccine development, molecular technology, and diagnostic technology
• More than 100 chapters covering all major groups of bacteria
• Written by an international panel of authors who are experts in their respective disciplines

Edited By Yi-wei Tang, Memorial Sloan-kettering Cancer Center, Weill Medical College Of Cornell University, New York, Ny, Usa, Max Sussman, Institute Of Cell And Molecular Biosciences, Medical School, Newcastle Upon Tyne, Uk, Dongyou Liu, Royal College Of Pathologists Of Australasia Quality Assurance Programs, Nsw, Australia, Ian Poxton, University Of Edinburgh, Edinburgh, Uk, Joseph Schwartzman, Geisel School Of Medicine At Dartmouth, Hanover Nh, Usa. Previous Edition: 2002. Includes Bibliographical References And Index.