Molecular Mechanisms of Parasite Invasion (Subcellular Biochemistry, Volume 47) [ISBN : 9780387782669] [Copyright Year : 2008]

All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells. Current and emerging approaches to studying invasion in apicomplexan parasites / Jeffrey Mital and Gary E. Ward Microneme proteins in apicomplexans / Vern B. Carruthers and Fiona M. Tomley Erythrocyte invasion by plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching / Manoj T. Duraisingh ... [et al.] Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of trypanosoma cruzi with host structures / Maria Jølia M. Alves and Walter Colli Calcium regulation and signaling in apicomplexan parasites / Kisaburo Nagamune ... [et al.] Trypanosoma cruzi: parasite and host cell signaling during the invasion process / Nobuko Yoshida and Mauro Cortez Host cell actin remodeling in response to cryptosporidium / Steven P. O'Hara ... [et al.] Host cell actin remodeling in response to trypanosoma cruzi: trypomastigote versus amastigote entry / Renato A. Mortara ... [et al.] Actin/myosin-based gliding motility in apicomplexan parasites / Kai Matuschewski and Herwig Schøler Roles of proteases during invasion and egress by plasmodium and toxoplasma / Timothy J. Dowse ... [et al.] Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by trypanosoma cruzi / Julio Scharfstein and Ana Paula C.A. Lima Biogenesis of and activities at the toxoplasma gondii parasitophorous vacuole membrane / Anthony P. Sinai The role of host cell lysosomes in trypanosoma cruzi invasion / G. Adam Mott and Barbara A. Burleigh Leishmania invasion and phagosome biogenesis / Robert Lodge and Albert Descoteaux Plasmodium sporozoite passage across the sinusoidal cell layer / Ute Frevert ... [et al.] Transepithelial migration by toxoplasma / Antonio Barragan and Niclas Hitziger The microsporidian polar tube and its role in invasion / Frederic Delbac and Valerie Polonais Intestinal invasion by entamoeba histolytica / Shahram Solaymani-Mohammadi and William A. Petri, Jr. Front Matter....Pages i-xx Current and Emerging Approaches to Studying Invasion in Apicomplexan Parasites....Pages 1-32 Microneme Proteins in Apicomplexans....Pages 33-45 Erythrocyte Invasion by Plasmodium falciparum : Multiple Ligand-Receptor Interactions and Phenotypic Switching....Pages 46-57 Role of the gp85/Trans-Sialidase Superfamily of Glycoproteins in the Interaction of Trypanosoma cruzi with Host Structures....Pages 58-69 Calcium Regulation and Signaling in Apicomplexan Parasites....Pages 70-81 Trypanosoma cruzi: Parasite and Host Cell Signaling during the Invasion Process....Pages 82-91 Host Cell Actin Remodeling in Response to Cryptosporidium ....Pages 92-100 Host Cell Actin Remodeling in Response to Trypanosoma cruzi : Trypomastigote Versus Amastigote Entry....Pages 101-109 Actin/Myosin-Based Gliding Motility in Apicomplexan Parasites....Pages 110-120 Roles of Proteases during Invasion and Egress by Plasmodium and Toxoplasma ....Pages 121-139 Roles of Naturally Occurring Protease Inhibitors in the Modulation of Host Cell Signaling and Cellular Invasion by Trypanosoma cruzi ....Pages 140-154 Biogenesis of and Activities at the Toxoplasma gondii Parasitophorous Vacuole Membrane....Pages 155-164 The Role of Host Cell Lysosomes in Trypanosoma cruzi Invasion....Pages 165-173 Leishmania Invasion and Phagosome Biogenesis....Pages 174-181 Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer....Pages 182-197 Transepithelial Migration by Toxoplasma ....Pages 198-207 The Microsporidian Polar Tube and Its Role in Invasion....Pages 208-220 Intestinal Invasion by Entamoeba histolytica ....Pages 221-232 Back Matter....Pages 233-237 In biological terms, a parasite can be defined as a oean organism that grows, feeds and is sheltered on, or in, a different organism while contributing nothing to the survival of the host.a 1 This relationship is particularly intimate for parasitic protozoa (and single-celled fungi such as the Microsporidia), many of which not only penetrate tissue barriers, but gain entry into host cells. The entry mechanisms are as diverse as the organisms employing them and are often critical components of their pathogenic profile. All of the parasitic organisms highlighted in this new book represent medica "All of the parasitic organisms highlighted in this book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens - not only with regard to their clinical relevance but also the fascinating biology they reveal."--BOOK JACKET In biological terms, a parasite can be defined as 'an organism that grows, feeds and is sheltered on, or in, a different organism while contributing nothing to the survival of the host'. This book highlights various parasitic organisms that represent medically important human pathogens that contribute significantly to the global burden of disease.