MOLECULAR MECHANISMS OF OXYGEN ACTIVATION. EDITED BY OSAMU HAYAISHI. NEW YORK; LONDON: ACADEMIC PRESS, 1974. - XVI,678 S

Molecular Mechanisms of Oxygen Activation reviews some of the major advances that have been made in our understanding of the molecular mechanisms underlying oxygen activation, with emphasis on the role of oxygen activation in contemporary biological processes. The biological role of oxygenases in the metabolism of fatty acids and steroids is discussed, along with the functions of heme-containing dioxygenases, a-ketoglutarate-coupled dioxygenases, and pterin-requiring aromatic amino acid hydroxylases. This book is comprised of 14 chapters and begins with an overview of the general properties and biological functions of oxygenases, along with the chemical aspects of oxygen fixation reactions. The reader is then introduced to research concerning fatty acid and steroid oxygenases which has appeared in the literature since 1962, paying particular attention to the mechanism of oxygenation and the biosynthesis and metabolism of steroids. Subsequent chapters explore the biological functions of a variety of oxygenases such as heme-containing dioxygenases, copper-containing oxygenases, flavoprotein oxygenases, and pterin-requiring aromatic amino acid hydroxylases. Superoxide dismutase, cytochrome c oxidase, peroxidase, and bacterial monoxygenases are also considered. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv LIST OF CONTRIBUTORS , Pages xi-xiii PREFACE , Pages xv-xvi , OSAMU HAYAISHI 1 - GENERAL PROPERTIES AND BIOLOGICAL FUNCTIONS OF OXYGENASES , Pages 1-28 , OSAMU HAYAISHI 2 - OXYGENASES IN FATTY ACID AND STEROID METABOLISM , Pages 29-85 , MATS HAMBERG, BENGT SAMUELSSON, INGEMAR BJÖRKHEM, HENRY DANIELSSON 3 - HEME-CONTAINING DIOXYGENASES , Pages 87-133 , PHILIP FEIGELSON, FRANK O. BRADY 4 - NONHEME IRON DIOXYGENASE , Pages 135-165 , MITSUHIRO NOZAKI 5 - α-KETOGLUTARATE-COUPLED DIOXYGENASES , Pages 167-214 , MITCHEL T. ABBOTT, SIDNEY UDENFRIEND 6 - MICROSOMAL CYTOCHROME P-450-LINKED MONOOXYGENASE SYSTEMS IN MAMMALIAN TISSUES , Pages 215-244 , STEN ORRENIUS, LARS ERNSTER 7 - FLAVOPROTEIN OXYGENASES , Pages 245-283 , MARCIA S. FLASHNER, VINCENT MASSEY 8 - PTERIN-REQUIRING AROMATIC AMINO ACID HYDROXYLASES , Pages 285-369 , SEYMOUR KAUFMAN, DANIEL B. FISHER 9 - COPPER-CONTAINING OXYGENASES , Pages 371-404 , WALTER H. VANNESTE, ANDREAS ZUBERBÜHLER 10 - CHEMICAL MODELS AND MECHANISMS FOR OXYGENASES , Pages 405-451 , GORDON A. HAMILTON 11 - SUPEROXIDE DISMUTASE , Pages 453-477 , IRWIN FRIDOVICH 12 - Cytochrome c Oxidase , Pages 479-534 , PETER NICHOLLS, BRITTON CHANCE 13 - Peroxidase , Pages 535-558 , ISAO YAMAZAKI 14 - BACTERIAL MONOXYGENASES—THE P450 CYTOCHROME SYSTEM , Pages 559-613 , I.C. GUNSALSU, J.R. MEEKS, J.D. LIPSCOMB, P. DEBRUNNER, E. MÜNCK AUTHOR INDEX , Pages 615-650 SUBJECT INDEX , Pages 651-678 Molecular Biology: An International Series of Monographs and Textbooks , Pages 679-680