Molecular Mechanisms of Neurotransmitter Release (Advances in Neurobiology, XXXXXX)

Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters that control the function of postsynaptic neurons by acting on postsynaptic receptors. Recent decades have brought groundbreaking new developments and a wealth of knowledge to this field. In __Molecular Mechanisms of Neurotransmitter Release__, leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments. Comprehensive and cutting-edge, __Molecular Mechanisms of Neurotransmitter Release__ is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience. Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports. Front Matter....Pages i-xiii The Architecture of the Presynaptic Release Site....Pages 1-16 Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse....Pages 17-34 Roles of SNARE Proteins in Synaptic Vesicle Fusion....Pages 35-59 Roles and Sources of Calcium in Synaptic Exocytosis....Pages 61-84 Regulation of Presynaptic Calcium Channels....Pages 85-106 Synaptotagmin: Transducing Ca 2+ -Binding to Vesicle Fusion....Pages 107-134 Functional Interactions Among the SNARE Regulators UNC-13, Tomosyn, and UNC-18....Pages 135-156 Roles of the ELKS/CAST Family and SAD Kinase in Neurotransmitter Release....Pages 157-170 The Role of Potassium Channels in the Regulation of Neurotransmitter Release....Pages 171-185 Modulation of Neurotransmitter Release and Presynaptic Plasticity by Protein Phosphorylation....Pages 187-206 Synaptic Vesicle Endocytosis....Pages 207-238 Lipids and Secretory Vesicle Exocytosis....Pages 239-261 Neurotransmitter Reuptake and Synaptic Vesicle Refilling....Pages 263-295 Regulation of Neurotransmitter Release by Presynaptic Receptors....Pages 297-314 Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules....Pages 315-326 Differential Regulation of Small Clear Vesicles and Large Dense-Core Vesicles....Pages 327-339 Back Matter....Pages 341-347

Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters which control the function of postsynaptic neurons by acting on postsynaptic receptors. Recent decades have brought ground-breaking new developments and a wealth of knowledge to this field. In 'Molecular Mechanisms of Neurotransmitter Release', leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments.

Comprehensive and cutting-edge, 'Molecular Mechanisms of Neurotransmitter Release' is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience

This is a collection of methods of practical design, calculation and numerical examples that illustrate how organized, analytical reasoning can lead to the discovery of clear, direct solutions to pollution especially in the areas of biosolids management, treatment, disposal and beneficial use. Accompanying CD-ROM contains selected illustrations with some in color