Molecular Mechanisms of Aging (Sitzungsberichte der Heidelberger Akademie der Wissenschaften, 1990 / 1990/2)

**Contents:** Cognitive Functions and Aging.- Genetics and Biology of Aging.- Gene Expression.- Membranes and Aging.- Models.- Molecular Approaches to Age-Related Diseases. Front Matter....Pages I-VII Front Matter....Pages 1-1 The Brain Disease of Ageing — Epidemiology and Risk Factors of Senile Dementia (Alzheimer)....Pages 2-17 Cognition Related Functional, Praxis and Feeding Changes in CNS Aging and Alzheimer’s Disease and their Developmental Analogies....Pages 18-40 Front Matter....Pages 41-41 Genetical Aspects of Aging....Pages 42-50 Aging and DNA Repair....Pages 51-59 Front Matter....Pages 61-61 Transcription Factor Regulation In Brain: Focus on Activity and NMDA Dependent Regulation....Pages 62-76 New Methods for Detecting DNA Sequence Variation in Relation to Aging....Pages 77-88 Regulation of the Amyloid Gene of Alzheimer’s Disease....Pages 89-96 Front Matter....Pages 97-97 The Molecular Biology of Down Syndrome....Pages 98-109 Aging of cell membrane molecules: Band 3 and senescent cell antigen in neural tissue....Pages 110-123 Essential Macromolecular Structures for the Function of the Myelin Membrane of Central Nervous System....Pages 124-144 Front Matter....Pages 145-145 Transgenic Mouse Model of an Autosomal Dominant Disease: Familial Amyloidotic Polyneuropathy....Pages 146-154 Somatostatin and Brain Aging....Pages 155-174 Front Matter....Pages 175-175 Amyloidosis....Pages 176-184 Amyloid ßA4 protein deposition in Alzheimer’s disease and Down’s Syndrome....Pages 185-194 Alzheimer’s Disease and Animal Models....Pages 195-204 Back Matter....Pages 205-206 A high-level text on the molecular and genetic aspects of human ageing with reference to cognitive functions and age-related diseases.