Molecular Mechanisms of Adult Stem Cell Aging (Else Kroner-Fresenius-Symposia, Vol. 1)

"There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field. The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis. Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology."--Publisher's description Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging : a meeting report and introduction to the field / Rudolph, K.L. Speakers at the Symposium / Hartmann, D. Hematopoietic stem cell aging and fate decision / Illing, A., Ju, Z. Alterations of systemic environment impair stem cell function during aging / Song, Z., Ju, Z. Novel insights into regulation of stem cell aging by aging of the niche and lterations in systemic factors / Geiger, H. Aging and hematopoietic malignancies / Gompf, A. Intestinal stem cell aging / Sperka, T., Rudolph, K.L. Molecular mechanisms of aging in muscle stem cells / Tümpel, S. Free radicals and stem cell aging / Guachalla, L.M. DNA damage, checkpoint responses, and cell cycle control in aging stem cells / Sperka, T., Nalapareddy, K., Rudolph, K.L. 000312641......Page 2 000312642......Page 8 000312643......Page 10 000312644......Page 12 000312645......Page 26 000312646......Page 47 000312647......Page 55 000312648......Page 65 000312650......Page 72 000312651......Page 88 000312652......Page 97 000312653......Page 104 000312654......Page 114