Molecular Mechanisms in Spermatogenesis (Advances in Experimental Medicine and Biology, 636)

In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field. In The Past Thirty Years, Significant Advances Have Been Made In The Field Of Reproductive Biology In Unlocking The Molecular And Biochemical Events That Regulate Spermatogenesis In The Mammalian Testis. It Was Possible Because Of The Unprecedented Breakthroughs In Molecular Biology, Cell Biology, Immunology, And Biochemistry. This Book Includes A Collection Of Chapters Written By Colleagues On The Latest Development In The Field Using Genomic And Proteomic Approaches To Study Spermatogenesis, As Well As Different Mechanisms And/or Molecules Including Environmental Toxicants And Transcription Factors That Regulate And/or Affect Spermatogenesis. Spermatogenesis And Cycle Of The Seminiferous Epithelium / Rex A. Hess And Luiz Renato De Franca -- Testicular Development And Spermatogenesis : Harvesting The Postgenomics Bounty / Antoine D. Rolland, Bernard Jogou And Charles Pineau -- Estrogens And Spermatogenesis / Chandrima Shaha -- Selenium, A Key Element In Spermatogenesis And Male Fertility / Carla Boitani And Rossella Puglisi -- Extracellular Matrix And Its Role In Spermatogenesis / Michelle K.y. Siu And C. Yan Cheng -- Inflammatory Networks In The Control Of Spermatogenesis : Chronic Inflammation In An Immunologically Privileged Tissue? / Moira K. O'bryan And Mark P. Hedger -- Transcription Regulation In Spermatogenesis / Wing-yee Lui And C. Yan Cheng -- Proteases And Their Cognate Inhibitors Of The Serine And Metalloprotease -- Subclasses, In Testicular Physiology / Brigitte Le Magueresse-battistoni -- Antioxidant Systems And Oxidative Stress In The Testes / R. John Aitken And Shaun D. Roman -- Nitric Oxide And Cyclic Nucleotides : Their Roles In Junction Dynamics And Spermatogenesis / Nikki P.y. Lee And C. Yan Cheng -- The Sertoli Cell Cytoskeleton / A. Wayne Vogl, Kuljeet S. Vaid And Julian A. Guttman -- Blood-testis Barrier, Junctional And Transport Proteins And Spermatogenesis / Brian P. Setchell -- Cross-talk Between Tight And Anchoring Junctions : Lesson From The Testis / Helen H.n. Yan ... [et Al.] -- The Role Of The Leydig Cell In Spermatogenic Function / Renshan Ge, Guorong Chen And Matthew P. Hardy. Edited By C. Yan Cheng. Includes Bibliographical References And Index. Front Matter....Pages i-xvii Spermatogenesis and Cycle of the Seminiferous Epithelium....Pages 1-15 Testicular Development and Spermatogenesis: Harvesting the Postgenomics Bounty....Pages 16-41 Estrogens and Spermatogenesis....Pages 42-64 Selenium, a Key Element in Spermatogenesis and Male Fertility....Pages 65-73 Extracellular Matrix and Its Role in Spermatogenesis....Pages 74-91 Inflammatory Networks in the Control of Spermatogenesis....Pages 92-114 Transcription Regulation in Spermatogenesis....Pages 115-132 Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology....Pages 133-153 Antioxidant Systems and Oxidative Stress in the Testes....Pages 154-171 Nitric Oxide and Cyclic Nucleotides: Their Roles in Junction Dynamics and Spermatogenesis....Pages 172-185 The Sertoli Cell Cytoskeleton....Pages 186-211 Blood-Testis Barrier, Junctional and Transport Proteins and Spermatogenesis....Pages 212-233 Cross-Talk between Tight and Anchoring Junctions—Lesson from the Testis....Pages 234-254 The Role of the Leydig Cell in Spermatogenic Function....Pages 255-269 Back Matter....Pages 271-274