Molecular Genetics of Endometrial Carcinoma (Advances in Experimental Medicine and Biology, 943)

This Comprehensive Text Provides A Much-needed Review Of A Disease That Is Currently Garnering The Interest Of Molecular Biologists, Translational Scientists, And Clinicians. The Volume Includes Emerging Developments In The Molecular Genetics Of Endometrial Carcinoma. In Addition To Covering The Basic Genetics Of Endometrial Carcinoma, Chapters Also Cover A Wide Range Of Signaling Pathways Implicated In Endometrial Carcinoma. A Section Of The Book Includes A Number Of Genetically Engineered Mouse Models, Which Contribute To Understanding The Role Of Various Genetic Alterations In The Development And Progression Of Endometrial Carcinoma. These Models Also Provide Preclinical Models For Developing Effective Targeted Therapeutic Approaches. Endometrial Carcinoma Is The Most Common Malignancy Of The Female Genital Tract In The United States And The Number Of Cases Continues To Increase Around The World. This Book Is A Meant To Serve As A Resource For A Wide Range Of Scientists, From Molecular Geneticists To Signal Transduction Biologists, As Well As To Both Clinicians And Scientists Interested In Developing Targeted Therapeutic Approaches For Women With Endometrial Carcinoma--publisher's Description. Part 1. Introduction. Epidemiology Of Endometrial Carcinoma: Etiologic Importance Of Hormonal And Metabolic Influences / Ashley S. Felix, Hannah P. Yang, Daphne W. Bell, And Mark E. Sherman -- Clinical Behavior And Treatment Of Endometrial Cancer / Divya Gupta -- Pathology Of Endometrial Carcinoma / Sigurd F. Lax -- Part 2. Molecular Profiling. Traditional Approaches To Molecular Genetic Analysis / Christopher J. Walker And Paul J. Goodfellow -- Next-generation Sequencing / Matthieu Le Gallo, Fred Lozy, And Daphne W. Bell -- Endometrial Carcinoma: Specific Targeted Pathways / Nuria Eritja, Andree Yeramian, Bo-juen Chen, David Llobet-navas, Eugenia Ortega, Eva Colas, Miguel Abal, Xavier Dolcet, Jaume Reventos, And Xavier Matias-guiu -- Part 3. Mouse Models. Lkb1 As A Tumor Suppressor In Uterine Cancer: Mouse Models And Translational Studies / Christopher G. Peña And Diego H. Castrillón -- Mig-6 Mouse Model Of Endometrial Cancer / Tae Hoon Kim, Jung-yoon Yoo, And Jae-wook Jeong -- Pi3k/pten/akt Genetic Mouse Models Of Endometrial Carcinoma / Ayesha Joshi And Lora Hedrick Ellenson. Lora Hedrick Ellenson, Editor. Includes Bibliographical References And Index. Front Matter....Pages i-xi Front Matter....Pages 1-1 Epidemiology of Endometrial Carcinoma: Etiologic Importance of Hormonal and Metabolic Influences....Pages 3-46 Clinical Behavior and Treatment of Endometrial Cancer....Pages 47-74 Pathology of Endometrial Carcinoma....Pages 75-96 Front Matter....Pages 97-97 Traditional Approaches to Molecular Genetic Analysis....Pages 99-118 Next-Generation Sequencing....Pages 119-148 Endometrial Carcinoma: Specific Targeted Pathways....Pages 149-207 Front Matter....Pages 209-209 LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies....Pages 211-241 Mig-6 Mouse Model of Endometrial Cancer....Pages 243-259 PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma....Pages 261-273 Back Matter....Pages 275-281