Molecular genetics, (Molecular biology; an international series of monographs and textbooks) (Pt. 3)

Molecular Genetics, Part III: Chromosome Structure explores the structure and modification of DNA, chromatin, and higher order organization and possible subunits of chromosomes at the molecular level. It describes major changes in concepts of chromatin structure and packaging of DNA based on studies of nuclease digests and electron micrographs; the role of restriction endonucleases in molecular genetics; the involvement of DNA topoisomerases in concerted breaking and rejoining of DNA backbone bonds; enzymatic methylation of DNA; and transcriptional units in eukaryotic chromosomes. Organized into seven chapters, this volume begins with an overview of the general properties of type I and type II restriction enzymes, basic aspects of restriction enzyme technology, and applications of restriction enzyme technology to the study of chromosome structure and function. It then discusses recombinant DNA technology; possible biological roles of DNA topoisomerases; recognition and control sequences in nucleic acids; composition and substructure of nucleosomes; analysis of chromosome fibers by electron microscopy; organization of fibers into chromosomes; and functional aspects of organization of chromosome fibers. Molecular biologists, geneticists, scientists, and electron microscopists will find this book extremely helpful. Content: MOLECULAR BIOLOGY , Page ii Front Matter , Page iii Copyright , Page iv Contributors to Part III , Page ix Preface , Pages xi-xii , J. HERBERT TAYLOR Contents of Part I , Page xiii Contents of Part II , Page xiv Chapter I - The Role of Restriction Endonucleases in Molecular Genetics , Pages 1-63 , MARC ZABEAU, RICHARD J. ROBERTS Chapter II - DNA Topoisomerases: Enzymes That Catalyze the Concerted Breaking and Rejoining of DNA Backbone Bonds , Pages 65-88 , JAMES C. WANG, LEROY F. LIU Chapter III - Enzymatic Methylation of DNA: Patterns and Possible Regulatory Roles , Pages 89-115 , J. HERBERT TAYLOR Chapter IV - Transcriptional Units in Eukaryotic Chromosomes , Pages 117-175 , ANN L. BEYER, STEVEN L. McKNIGHT, OSCAR L. MILLER JR. Chapter V - Recognition and Control Sequences in Nucleic Acids , Pages 177-245 , P. ANDREW BIRO, SHERMAN M. WEISSMAN Chapter VI - Nucleosomes: Composition and Substructure , Pages 247-313 , RANDOLPH L. RILL Chapter VII - Nucleosomes and Higher Levels of Chromosomal Organization , Pages 315-385 , JOHN C. HOZIER INDEX , Pages 387-389 Molecular Biology: An International Series of Monographs and Textbooks , Pages 391-392 This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.