Molecular Biotechnology of Fungal beta-Lactam Antibiotics and Related Peptide Synthetases (Advances in Biochemical Engineering / Biotechnology)

Cephalosporin C and its semisynthetic derivatives are very potent and widely used -lactam antibiotics of general and applied interest. 1. Class 5: Isomerases 2. Class 6: Ligases 3. Class 4: Lyases I 4. Class 4: Lyases II 5. Class 4: Lyases III 6. Class 3.4: Hydrolases I 7. Class 3.4: Hydrolases II 8. Class 3.4: Hydrolases III 9. Class 3.4: Hydrolases IV 10. Class 3.4: Hydrolases V 11. Class 3.4: Hydrolases VI 12. Class 3.2 Hydrolases VII EC 3.2.1.1-3.2.1.47 13. Class 3.2 Hydrolases VIII EC 3.2.48-3.2.1.149 14. Class 3.2-3.5: Hydrolases IX EC3.2.2-3.5.3 15. Class 3.5-3.12: Hydrolases X EC3.5.4-3.12.1 Index A : Synonym Index 16. Class 1: Oxidoreductases I EC 1.1.1.1-1.1.1.50 17. Class 1: Oxidoreductases II EC 1.1.1.51-1.1.1.54 18. Class 1: Oxidoreductases III EC 1.1.1.155-1.1.1.274 19. Class 1: Oxidoreductases IV EC 1.1.2-1.1.99 20. Class 1: Oxidoreductases V EC 1.2 21. Class 1: Oxidoreductases VI EC 1.3 v. 22. Class 1: Oxidoreductases VII EC1.4 v. 23. Class 1: Oxidoreductases VIII EC1.5 v. 24. Class 1: Oxidoreductases IX EC 1.6-1.8 v. 25. Class 1: Oxidoreductases X EC1.9-1.13 v. 26. Class 1: Oxidoreductases XI EC 1.14.11-1.14.14 v. 27. Class 1: Oxidoreductases XII EC 1.14.15-1.97 v. 28. Class 2: Transferases I EC 2.1.1 v. 29. Class 2: Transferases II EC 2.1.2.1-2.3.1.59 v. 30. Class 2: Transferases III EC 2.3.1.60-2.3.3.15 v. 31. Class 2: Transferases IV EC 2.4.1.1-2.4.1.89 v. 32. Class 2: Transferases V EC 2.4.1.90-2.4.1.232. Regulation of Cephalosporin Biosynthesis....Pages 1-43 Regulation of Penicillin Biosynthesis in Filamentous Fungi....Pages 45-90 Novel Genes Involved in Cephalosporin Biosynthesis: The Three-component Isopenicillin N Epimerase System....Pages 91-109 Compartmentalization and Transport in β-Lactam Antibiotics Biosynthesis....Pages 111-135 Control of Fluxes Towards Antibiotics and the Role of Primary Metabolism in Production of Antibiotics....Pages 137-178 Industrial Enzymatic Production of Cephalosporin-Based β-Lactams....Pages 179-215 Biochemistry and General Genetics of Nonribosomal Peptide Synthetases in Fungi....Pages 217-264 Each entry includes nomenclature, source organism, reaction and specificity, enzyme structure, isolation / preparation / mutation / application, stability, and literature references for each enzyme