Molecular Biology of the Lung: Volume I: Emphysema and Infection (Respiratory Pharmacology and Pharmacotherapy)

Library of Congress Cataloging-in-Publication Data Molecular biology of the lung / edited by RA Stockley p. cm. -(Respiratory pharmacology and pharmacotherapy) Contents: V. 1. Emphysema and infection -V 2 . Asthma and cancer. Front Matter....Pages I-VIII Application of Transgenic and Gene-Targeted Mice to Dissect Mechanisms of Lung Disease....Pages 1-15 Front Matter....Pages 17-17 Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige....Pages 19-36 α 1 -Antitrypsin Deficiency....Pages 37-53 Recombinant SLPI: Emphysema and Asthma....Pages 55-67 Elastase Inhibitors in the Lung: Expression and Functional Relationships....Pages 69-94 Regulation of Neutrophil Proteinases....Pages 95-112 Control of Connective Tissue Genes....Pages 113-130 Front Matter....Pages 131-131 Genetic Models of Bacterial Lung Infection....Pages 133-147 Genetics of Bacteria: Role in Pathogenesis of Infection of the Respiratory Tract....Pages 149-162 Polymerase Chain Reaction in the Diagnosis of Respiratory Tract Infections....Pages 163-180 Cystic Fibrosis....Pages 181-198 Respiratory Bacterial Infections in Patients with Cystic Fibrosis: Pathogenicity and Implications for Serine Proteinase Inhibitor Therapy....Pages 199-214 Back Matter....Pages 215-216