Molecular Biology And Its Application To Medical Mycology (nato Asi Series (closed) / Nato Asi Subseries H: (closed))

Presented here are recent achievements in molecular biology of non-pathogenic yeast and filamenous fungi as well as of human pathogens. Thebook is diveded into 4 sections: - Molecular Biology of Yeast; - Molecular Biology of Filamenous Fungi; - New Tools and Prospectives for Medical Mycology; - Fungal Morphogenesis. It focuses on aspects of medical mycology, namely isolation of specific genes and strategies for developing new targets for antifungal therapy. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Cell cycle regulation in fission yeast....Pages 3-5 Yeast genes overcoming growth arrest induced by 1, 10-phenantroline....Pages 7-11 Reverse genetics in a non-conventional yeast, Candida maltosa ....Pages 13-22 The complement C3D-binding receptor (CR2) of Candida albicans : Cloning and sequence analysis of a gene fragment homologous with a human CR2 cDNA clone....Pages 23-30 Biology, physiology, biochemistry and molecular genetics of Trichosporon yeasts....Pages 31-38 Physiological functions of vacuoles in yeast: Mechanism of sequestration of metabolites and proteins into vacuoles....Pages 39-45 Characterization of a Candida albicans -specific DNA fragment....Pages 47-52 Recent advances in the molecular biology of Cryptococcus neoformans ....Pages 53-61 Molecular biology of Kluyveromyces lactis ....Pages 63-73 Gene regulatory circuits in Saccharomyces cerevisiae as a tool for the identification of heterologous eukaryotic regulatory elements....Pages 75-83 Front Matter....Pages 85-85 Molecular breeding in filamentous fungi with emphasis on Aspergilli ....Pages 87-95 TubB α-tubulin is essential for sexual development in Aspergillus nidulans ....Pages 97-104 The heat shock response of Neurospora crassa ....Pages 105-116 Blue light regulated expression of geranylgeranyl pyrophosphate synthetase (Albino-3) gene in Neurospora crassa ....Pages 117-124 Expression of genes for the biosynthesis of penicillin....Pages 125-138 Front Matter....Pages 139-139 Imaging of the yeast killer phenomenon....Pages 141-148 cDNA cloning of Candida albicans aspartic proteinase and its diagnostic application....Pages 149-158 Molecular biotyping of Candida in experimental and clinical studies....Pages 159-168 Homoserine dehydrogenase as a selective target molecule for antifungal action....Pages 169-177 Molecular mechanisms of antifungal activity and fungal resistence: focus on inhibitors of ergosterol biosynthesis....Pages 179-197 Front Matter....Pages 139-139 Molecular studies on azole sensitivity in fungi....Pages 199-213 Antifungal chemotherapy and drug strategies: Projected clinical needs....Pages 215-220 Funding medical mycology: Strategies for attracting the private sector....Pages 221-223 Front Matter....Pages 225-225 Chromosomal organization of Histoplasma capsulatum ....Pages 227-228 Chitin, chitin synthase and chitin synthase conserved region homologues in Wangiella dermatitidis ....Pages 229-242 Addition of unsaturated fatty acids down-modulates heat shock gene expression and produces attenuated strains in the fungus Histoplasma capsulatum ....Pages 243-250 Back Matter....Pages 251-262 Proceedings of the NATO Advanced Research Workshop on Molecular Biology and its Application to Medical Mycology, held at Taormina, Italy, January 6-8, 1992