Molecular Basis of Nutrition and Aging : A Volume in the Molecular Nutrition Series

__Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series__ focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. * Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging * Explores how nutritional factors are involved in the pathogenesis of aging across body systems * Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition Content: Front Cover Molecular Basis of Nutrition and Aging Copyright Page Contents List of Contributors Introduction to the Molecular Basis of Nutrition and Aging Series Preface Acknowledgments I. Introductory Aspects on Aging and Nutrition 1 Molecular and Cellular Basis of Aging Introduction Biological Principles of Aging Occurrence, Accumulation, and Consequences of Molecular Damage Homeodynamics and the Homeodynamic Space Nutrition and Food for Aging Interventions Nutritional Hormetins Conclusions Summary Points References. 2 Unraveling Stochastic Aging Processes in Mouse Liver: Dissecting Biological from Chronological AgeIntroduction Pathological Parameters are only Partially Associated with Chronological Age Intraorgan Specific Biological Phenotypes Tissue-Specific Biological Phenotypes Gene Expression Profiles Related to Pathological Aging Parameters Gene Expression Profiles Correlating with Pathological Parameters are Largely Specific to the Pathological Parameters Future Perspectives Conclusion References 3 Nutrigenomics and Nutrigenetics: The Basis of Molecular Nutrition Introduction. Nutrigenetics of Omega-3 PUFA in CVDNutrigenetics of Omega-3 PUHA in Cancer DNA Damage and Nutrients Cellular Senescence and Nutrients Epigenetics and Nutrients Summary Points References 4 Diet and Longevity Phenotype Introduction Main Text Nutrient Components and Aging Process Crucial Role of Fatty Acid Component Genomic Studies and Importance of Palmitoleic Acid The Central Position of Energy Sensor Systems The Involvement of Sympathetic System Epigenetic Linkage of Aging and Nutrition Summary References 5 Nutrition in the Elderly: General Aspects Introduction. Malnutrition in the Elderly: Definition and General AspectsCauses of Malnutrition in the Elderly Malnutrition: Possible Correction With Supplements in the Elderly Nutrient-Sensing Pathways Nutrient-Gene Interaction in the Elderly (Nutrigenomic Approach) Conclusions and Perspectives Summary Points Acknowledgments References 6 Nutrition in the Hospitalized Elderly Introduction Pathogenesis of Malnutrition in Hospitalized Elderly The Interaction Between Aging, Health Status, Hospital Environment, and Nutritional Status Why Are Hospitalized Older Adults Nutritionally Vulnerable? Age-Related ChangesAnorexia of Aging Changes in the Body Composition Taste, Smell, and Mastication Dysfunction Gastrointestinal Changes Medical Causes Use of Multiple Medications Functional and Psychosocial Factors Hospital Environment-Related Risks Clinical Consequences of Malnutrition in Hospital Malnutrition Screening and Assessment in Hospitalized Elderly Malnutrition Screening as a Part from Comprehensive Geriatric Assessment (CGA) Comprehensive Nutritional Assessment Nutritional History Physical and Clinical Assessment Anthropometry The Biochemical Investigations.

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health.

In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others.

Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations.

• Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging
• Explores how nutritional factors are involved in the pathogenesis of aging across body systems
• Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

"This volume synthesizes research on the underlying nutritional issues associated with aging, including the molecular, cellular, and systemic consequences of diet, nutrition, and health. It also explores the nutritional factors involved in aging, from the biomolecular level to individual health, including the effects of specific dietary compounds and interventions"--OCLC