Molecular Basis of Lymphokine Action (Experimental Biology and Medicine (18))

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth­ odology were the B-cell growth and differentiation factors, in partic­ ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor. Front Matter....Pages i-xxviii Front Matter....Pages 1-1 Tumor Growth Factors....Pages 3-12 Front Matter....Pages N1-N1 Suppressor T Cell Receptor and Functional Molecule....Pages 13-20 Role of Glycosylation Inhibiting Factor (GIF), a Phospholipase Inhibitory Protein, in the Generation of Antigen-Specific Suppressor T Cells....Pages 21-31 Characterization of GAT-Specific Suppressor Factors and Comparison to Other Antigen-Specific Factors....Pages 33-46 Soluble Immune Response Suppressor (SIRS) Mediated Inhibition of Cell Division....Pages 47-58 Differentiation and Proliferation of CD8 + Suppressor T Lymphocytes....Pages 59-71 Front Matter....Pages 72-72 Molecular Studies on Murine Interleukin 1....Pages 73-81 Multiple Biological Activities of Human Interleukin-1....Pages 83-95 A Membrane form of IL-1 — Identification and Control of Expression....Pages 97-104 Characterization of Interleukin-1 Receptors....Pages 105-116 T Cell Interleukin 1....Pages 117-122 Front Matter....Pages N2-N2 Molecular structure and immunological function of human B cell differentiation factor (BSF2)....Pages 123-136 Current Studies Examining Regulation of the Human B Cell Cycle....Pages 137-148 Two Types of Mouse Helper T Cell Clone: Differences in B Cell Help and Lymphokine Synthesis....Pages 149-159 Front Matter....Pages 160-160 Two Step Activation of the Interleukin-2 Autocrine Loop May be Involved in ATL Development....Pages 161-169 The Human High Affinity Interleukin-2 Receptor....Pages 171-179 Regulation of IL2 and Related Genes at the mRNA Level....Pages 181-191 Effects of Interleukin 2 to Promote Prothymocyte and Early Thymocyte Proliferation and Differentiation and to Increase Cyclic GMP Levels....Pages 193-206 Biological Significance of Interleukin 2 Receptor Associated Molecules....Pages 207-216 Identification of a Novel Interleukin-2 Receptor Subunit....Pages 217-221 Front Matter....Pages 222-222 In vivo Antitumor Activities of Tumor Necrosis Factor-Alpha....Pages 223-232 Life after IL2....Pages 233-244 Regulatory Polypeptides in the Lympho-Hemopoietic System....Pages 245-260 Cachectin/TNF: A Mediator of Lethal Endotoxemia....Pages 261-269 The Molecular Complex of Macrophage Migration Inhibitory Activity (MIF) and its Role in Inflammatory Reactions....Pages 271-281 Front Matter....Pages 282-282 Molecular Biology of Interleukin-3....Pages 283-294 The Molecular and Biological Properties of the Human and Murine Members of the CSF-1 Family....Pages 295-311 Isolation and Characterization of Mouse and Human cDNA Clones Encoding IL-4 and IgA-Enhancing Factor/Eosinophil CSF (IL-5)....Pages 313-324 Molecular Cloning and Characterization of the Human Gene for Interleukin-3 (IL-3)....Pages 325-337 Structure-Function Studies of Lymphokines by Total Chemical Synthesis....Pages 339-351 Front Matter....Pages 352-352 Cytokines in Metabolic Bone Disease....Pages 353-358 Lymphokine Production in Autoimmunity: Usefulness of mRNA Assays....Pages 359-369 Interleukin-2 Receptor Directed Immunosuppressive Therapy....Pages 371-392 An Improved Method for the Generation of Human Activated Killer Cells....Pages 393-407 Growth and Differentiation Factors for Human Metachromatically Staining Cells....Pages 409-418 Front Matter....Pages N3-N3 Lymphokine Research and the Biology of Immunologic Diseases....Pages 419-428 Front Matter....Pages N4-N4 Summary of the Interleukin 1 Workshop Discussions....Pages 429-441 Hematopoietic Growth Factors....Pages 443-447 Fifth International Lymphokine Workshop: Summary of Suppressor/Effector Factors Session....Pages 449-453 Clinical Uses of Lymphokines Workshop Summary....Pages 455-461 Front Matter....Pages N4-N4 Workshop Summary: Interleukin 2....Pages 463-469 Summary of Workshop on “Lymphokines Activating Cells for Killer Functions”....Pages 471-474 B Cell Stimulatory Factors....Pages 475-478 Back Matter....Pages 479-481