Molecular basis of biological activity : proceedings of a symposium on the Molecular Basis of Biological Activity held in Caracas

Molecular Basis of Biological Activity documents the proceedings of a symposium on the Molecular Basis of Biological Activity held in Caracas, Venezuela, July 11-17, 1971. This was the First Meeting of the Pan-American Association of Biochemical Societies (PAABS), and was organized by the Asociacion Venezolana de Bioquimica. The book begins by presenting a lecture on advances in the study of the mechanism of polysaccharide synthesis. This is followed by studies on rabbit muscle aldolase; the catalytic function of a-glycerolphosphate dehydrogenase; the functional and structural roles of metals in metalloenzymes; and enzyme adaptation in mammals. Separate chapters cover collagen biosynthesis and the mechanisms involved in its regulation; the organization of lipids in bilayers; the behavior of water-lipid interactions; the permease or transport systems in the mitochondrial membrane; and interaction between TTX and STX with isolated nerve membrane constituents. The final chapter examines the coupling of respiration via specific dehydrogenases to the transport of amino acids and many sugars. Content: Front Matter , Page iii Copyright , Page iv CONTRIBUTORS , Pages vii-viii PREFACE , Page ix , D.R. Whitaker Chairman INTRODUCTION TO GUSTAV EMBDEN LECTURE , Pages 1-3 , Severo Ochoa GUSTAV EMBDEN LECTURE “THE ROLE OF POLYPRENOLS IN POLYSACCHARIDE SYNTHESIS” , Pages 5-11 , LUIS F. LELOIR Metabolite Effects on Structure-Function Relationships in Glycogen Phosphorylase , Pages 13-52 , Neil B. Madsen COMPARATIVE STUDIES ON THE STRUCTURE AND MECHANISM OF ACTION OF ALDOLASES , Pages 53-75 , B.L. Horecker SOME CATALYTIC AND REGULATORY PROPERTIES OF L-GLYCEROL-3-PHOSPHATE DEHYDROGENASE , Pages 77-101 , Rafael Apitz-Castro MECHANISM AND REGULATION OF ACETYL CoA CARBOXYLATION: INTERSUBUNIT TRANSLOCATION OF THE BIOTIN PROSTHETIC GROUP , Pages 103-126 , M.D. Lane, R.B. Guchhait, S.E. Polakis, J. Moss REGULATION OF GLUTAMINE METABOLISM IN ESCHERICHIA COLI BY ENZYME CATALYZED ADENYLYLATION AND DEADENYLYLATION OF GLUTAMINE SYNTHETASE , Pages 127-143 , E.R. Stadtman, A. Ginsburg, W.B. Anderson, A. Segal, M.S. Brown, J.E. Ciardi SOME ASPECTS OF FUNCTIONAL AND STRUCTURAL ROLES OF METALS IN METALLOENZYMES , Pages 145-168 , Bert L. Vallee REGULATION OF OXYGEN DISSOCIATION BY 2,3-DIPHOSPHOGLYCERATE IN THE HUMAN ERYTHROCYTE , Pages 169-196 , B.F. Cameron, C.-Y. Lian, O.J. Carvajalino, S. Roth, D.R. Harkness CONTROL OF MITOCHONDRIAL ACTIVITY BY METABOLITES IN THE HEMOGLOBIN-FREE PERFUSED LIVER , Pages 197-219 , Bolko Brauser, Theodor Bücher, Helmut Sies, Hans Versmold ENZYME ADAPTATION IN MAMMALS , Pages 221-273 , Hermann Niemeyer, Tito Ureta COLLAGEN BIOSYNTHESIS: A REGULATORY MECHANISM , Pages 275-293 , Marcos Rojkind, Samuel Zinker, Lino Díaz de León THE MOTION AND ORIENTATION OF LIPIDS IN MULTIBILAYER STRUCTURES , Pages 295-311 , Henry Schneider HYDROPHOBIC-HYDROPHILIC BALANCE AT THE CELL MEMBRANE. ITS RELATIONSHIP TO PERMEABILITY PHENOMENA , Pages 313-330 , CERBON S. JORGE THE ENERGY-DEPENDENT TRANSPORT OF CA 2+ ACROSS THE MITOCHONDRIAL MEMBRANE , Pages 331-344 , Albert L. Lehninger RELATIONSHIP BETWEEN PERITUBULAR COUPLING OF Na AND K FLUXES AND Na ABSORPTION IN KIDNEY TUBULES , Pages 345-355 , Guillermo Whittembury INTERACTION OF BLOCKING AGENTS TTX AND STX OF THE EXCITABLE MEMBRANE SODIUM-CHANNEL WITH CHOLESTEROL MONOLAYERS , Pages 357-371 , FLOR V. BARNOLA, GERMAN CAMEJO, RAIMUNDO VILLEGAS SUGAR AND AMINO ACID TRANSPORT MECHANISMS IN ISOLATED BACTERIAL MEMBRANE VESICLES , Pages 373-409 , H.R. Kaback, E.M. Barnes Jr., A.S. Gordon, F.J. Lombardi, Grace K. Kerwar