Molecular approaches to immunology : proceedings of the Miami Winter Symposium, January 13-17, 1975

Molecular Approaches to Immunology is the 9th volume of the series''Miami Winter Symposia''. This volume presents papers that cover various aspects about cellular and modern immunology. Cellular immunology deals with the interactions of cells and molecules of the immune system and how these interactions help eliminate pathogens. The main goal of this book is to discuss and provide basic assumptions, approaches, and direction about the advances in the research of immunological science. In relation to this, the chapters of the book examine the recognition of antigen by T-lymphocytes, the role of cell interactions in determining the immune responsiveness, and the concepts behind clonal selection. The book also explains the different genes coding used for antibodies and the characterization of cell surface receptors at molecular level. Furthermore, it examines the evidences for genetic restrictions in cell interactions and the chemical properties of thymosin used in physiological studies. Discussions on the immunoregulation and immunological tolerance by T cells and the growth control of mammalian cells are also presented in this volume. This compilation will be invaluable to biologists, medical practitioners, professors, and students. Content: Front Matter , Page iii Copyright , Page iv SPEAKERS, CHAIRMEN, AND DISCUSSANTS , Pages ix-x PREFACE , Pages xi-xii THE SIXTH FEODOR LYNEN LECTURE: THE SHOCK OF MOLECULAR RECOGNITION , Pages 1-21 , GERALD M. EDELMAN THE SUBJECT AND STYLE OF MODERN IMMUNOLOGY: AN INTRODUCTION , Pages 23-38 , GERALD M. EDELMAN CURRENT CONCEPTS IN CELLULAR IMMUNOLOGY , Pages 39-53 , H.N. CLAMAN RECOGNITION OF ANTIGEN BY T LYMPHOCYTES , Pages 55-78 , G.E. ROELANTS THE LOGIC OF CELL INTERACTIONS IN DETERMINING IMMUNE RESPONSIVENESS , Pages 79-107 , MELVIN COHN THE USE OF MUTANT MYELOMA CELLS TO EXPLORE THE PRODUCTION OF IMMUNOGLOBULINS , Pages 109-129 , M.D. SCHARFF, B. BIRSHTEIN, B. DHARMGRONGARTAMA, L. FRANK, T. KELLY, W.M. KUEHL, D. MARGULIES, S.L. MORRISON, J.-L. PREUD'HOMME, S. WEITZMAN IMMUNOGLOBULIN GENES IN A MOUSE MYELOMA AND IN MUTANT CLONES , Pages 131-152 , C. Milstein, K. Adetugbo, G.G. Brownlee, N.J. Cowan, N.J. Proudfoot, T.H. Rabbitts, D.S. Secher GENES CODING FOR ANTIBODIES , Pages 153-171 , A.R. WILLIAMSON, A.J. McMICHAEL THE ORGANIZATION AND DIVERSITY OF IMMUNOGLOBULIN κ AND λ GENES , Pages 173-188 , P. LEDER, T. HONJO, D. SWAN, S. PACKMAN, M. NAU, B. NORMAN CELL SURFACE ANTIGENS AND CELL SURFACE PROTEINS: Problems and Approaches for Protein Chemistry , Pages 189-209 , BRUCE A. CUNNINGHAM THE ROLE OF PRODUCTS OF THE HISTOCOMPATIBILITY GENE COMPLEX IN IMMUNE RESPONSES , Pages 211-242 , DAVID H. KATZ, MARTIN E. DORF, DIETER ARMERDING, BARUJ BENACERRAF THE ROLE OF THYMOSIN AND THE ENDOCRINE THYMUS ON THE ONTOGENESIS AND FUNCTION OF T-CELLS , Pages 243-265 , A.L. GOLDSTEIN, G.B. THURMAN, G.H. COHEN, J.A. HOOPER IMMUNOREGULATION BY T CELLS , Pages 267-288 , RICHARD K. GERSHON CONTROL OF GROWTH OF MAMMALIAN CELLS , Pages 289-301 , ROBERT W. HOLLEY, IAN S. TROWBRIDGE RESTRICTED CLONAL RESPONSES: A TOOL IN UNDERSTANDING ANTIBODY SPECIFICITY , Pages 303-338 , E. HABER, M.N. MARGOLIES, L.E. CANNON, M.S. ROSEMBLATT REPETITIVE HINGE REGION SEQUENCES IN A γ3 HEAVY CHAIN DISEASE PROTEIN-ISOLATION OF AN 11,000 DALTON FRAGMENT , Page 339 , B.F. Frangione, J.B. Adlersberg, E.C. Franklin STRUCTURAL CHARACTERIZATION OF A MUTANT HUMAN LAMBDA TYPE L-CHAIN IMMUNOGLOBULIN , Page 340 , Fred A. Garver, Lebe Chang, Takashi Isobe, Elliott F. Osserman HETEROGENEITY OF THE C-REGION OF AN IgG1 IMMUNOGLOBULIN: THE STRUCTURE OF γ-HEAVY CHAIN DISEASE PROTEIN BAZ , Page 341 , Fred A. Garver, Lebe Chang, Byron McGuire GROWTH FACTOR FOR A VIRAL TRANSFORMED CELL FROM RAT LIVER AND HEMICORPUS PERFUSIONS , Page 342 , A. Lipton, C.J. Roehm, J.W. Robertson, J.M. Dietz, L.S. Jefferson LYMPHOCYTE RESPONSES TO MITOGENS AND ANTIGENS IN AGAROSE-GEL CULTURES , Page 343 , E. Kondracki, F. Milgrom STEROL SYNTHESIS IN NORMAL, PHYTOHEMAGGLUTININ-STIMULATED, AND LEUKEMIC MOUSE LYMPHOCYTES , Page 344 , H.W. Chen, H.J. Heiniger, A.A. Kandutsch CAN PROTEIN SYNTHESIS IN CULTURED CELLS BE REGULATED BY MEMBRANE-MEDIATED EVENTS? , Page 345 , G. Koch, P. Bilello, R. Mittelstaedt, A. Hoffman, L. Fisher ALTERATION OF MEMBRANE ANTIGENS BY TRYPSIN , Page 346 , J.A. Molinari, S. Sinka, D. Platt IgM Complex Receptors on T and B Lymphocytes , Page 347 , H. Whitten, E.W. Lamon, B. Anderson B AND T LYMPHOCYTES IN DYSGAMMAGLOBULINEMIA , Page 348 , B.Q. Lanier, A.S. Goldman, N.S. Harris THE ROLE OF THYMIC EXTRACT IN TRANSFER OF DELAYED HYPERSENSITIVITY (D.H.S.) AND IMMUNOSTIMULATION , Page 349 , Elias G. Elias, Robert M. Cohen GROWTH PROPERTIES AND ALLOANTIGENIC EXPRESSION OF MURINE LYMPHOBLASTIC CELL LINES GROWN IN SUSPENSION CULTURE , Page 350 , R.K. Zwerner, R.T. Acton REGULATION OF Ab ACTIVITY OF RABBIT (Rab) Ig + LYMPHOCYTES (LC) BY PRODUCTS OF Rab Ig − LC , Page 351 , Clara Bell EVIDENCE FOR THE GENETIC CONTROL OF ANTIGENIC MODULATION , Page 352 , W. Liang, E.P. Cohen THE RESPONSE OF CONGENITALLY ATHYMIC (NUDE) MICE TO INFECTION WITH MYCOBACTERIUM BOVIS (STRAIN BCG) , Page 353 , N.A. Sher, S.D. Chaparas, L.E. Greenberg, E.B. Merchant, J. Vickers NONSPECIFIC STIMULATORS OF THE IMMUNE SYSTEM , Page 354 , Benjamin Becker, Julian R. Kaufman