Molecular and Cellular Biology of Prostate Cancer

These proceedings of the 5th Prouts Neck Meeting on Prostate Cancer, held in October, 1989, highlight the many advances in the understanding of prostatic growth and function at the cellular and molecular levels which have been registered since the first Prouts Neck Meeting in 1985, a meeting which also focused on the then current concepts and basic approaches to understanding prostate cancer. Inter­ vening Prouts Neck Meetings in 1986, 1987 and 1988 were devoted to treatment, image cytometry and clinical markers. As before, the Prouts Neck tradition of bringing together an international, multidiscipli­ nary group of experts for 3 days to exchange ideas and new data, in the relaxed atmosphere of an old iun on the scenic Maine coast, proved to be an ideal combination for a highly successful conference. Accordingly, the Organ System Program of the National Cancer Institute plans to use the Prouts Neck model for future conferences on other solid tumors (bladder in 1990 and kidney in 1991) and will return to the prostate in 1992. A new dimension was added to the current program through the inclusion of a poster session to recognize the research of pre-and postdoctoral investigators. The posters were judged by Drs. Collette Freeman, Frank French, Shutsung Liao, Robert Matusik and Henry Sun. The three winners, in alphabeti­ cal order, were John Fabian, Robert Getzenberg and Ming Fong-Lin. Front Matter....Pages i-xii Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins....Pages 1-13 Mechanism of Growth Regulation of Androgen Responsive Cells....Pages 15-26 The Impact of Androgen, Extracellular Matrix, and Stroma Upon Proliferation and Differentiation of Benign and Malignant Prostate Epithelial Cells....Pages 27-50 Therapeutic Approaches to Activating Programmed Cell Death of Androgen-Independent Prostatic Cancer Cells....Pages 51-63 Cell Motility and Structural Harmonics in Prostate Cancer....Pages 65-72 Back Matter....Pages 73-74 Studies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary Cancers....Pages 75-79 Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia....Pages 81-90 Fibroblast-Mediated Human Epithelial Tumor Growth and Hormonal Responsiveness in Vivo....Pages 91-102 Polyamine Requirement of Prostate Cancer Cell Proliferation....Pages 103-114 Heparin-Binding (Fibroblast) Growth Factor/Receptor Gene Expression in the Prostate....Pages 115-126 Characterization and Partial Purification of a Non-Heparin-Binding Prostate Growth Factor from Cancerous Human Prostate....Pages 127-140 Back Matter....Pages 141-145 Transforming Growth Factor α: A Potential Autocrine Growth Regulator in Prostatic Carcinoma....Pages 147-156 Prostatic Growrh Factors (PrGFs)——From the Identification of Probasin to the Role of PrGFs....Pages 157-165 Urogenital Sinus Derived Growth Inhibitory Factor....Pages 167-174 Growth Factor Antagonists in Prostatic Cancer: Suramin and Cytotoxic Polyamines as Potential Therapy....Pages 175-184 Transforming Growth Facfors in Human Prostate Cancer....Pages 185-202 Gene Products as the Motivating Force in the Prostate Cell’s Response to Androgens....Pages 203-213 Back Matter....Pages 215-217 Molecular Biology of Prostate-Specific Antigen....Pages 219-222 Structure and Expression of the Androgen Receptor in Normal Tissues and in Prostate Carcinoma Cell Lines....Pages 223-227 Structural Analysis and Gene Expression of TR2 Receptor and TR3 Receptor....Pages 229-234 Back Matter....Pages 261-266 cDNA Cloning, Antibody Production and Immunohistochemical Localization of the Androgen Receptor....Pages 235-241 New Approaches to Studies on the Androgen Receptor....Pages 243-252 Specific Receptors for Vitamin D 3 in Human Prostatic Carcinoma Cells....Pages 253-260 Back Matter....Pages 261-266 Role of Androgens and Extracellular Matrix in the Growth and Differentiation of Benign and Malignant Prostate Epithelial Cells....Pages 267-269 Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins....Pages 271-272 Effect of Transformation on Rat Prostatic Fibroblasts: Alterations in Extracellular Matrix and Cytoskeleton Gene Expression with Retention of Androgen Responsiveness and Androgen Receptor Expression....Pages 273-274 A Potential Role for the MDR-1 Gene in the Development of Androgen-Independent Tumors....Pages 275-276 Relevance of Low Androgen Levels and Adrenal Androgens in the Growth of Transplantable Human Prostatic Carcinomas....Pages 277-278 Growth-Stimulating Effect of Growth Factor(s) from Androgen Independent Tumor Cells (CS 2-Cell) on Androgen Responsive Tumor Cells (SC 115-Cell)....Pages 279-279 The Cellular Form of Human Prostatic Acid Phosphatase May Function as a Phosphotyrosyl Protein Phosphatase in Cells....Pages 281-284 Expression of PSA in LNCaP Cells in Culture....Pages 285-286 Allelic Expression of the Mouse Ren-1 Genes in the Anterior Prostate (Coagulating Gland)....Pages 287-287 Back Matter....Pages 363-367 Genomic Alterations in Prostatic Cancer....Pages 289-297 Regulation of Gene Expression in the Prostate....Pages 299-314 Androgen Regulation of HBGF-I (aFGF) mRNA and Characferization of the Androgen-Receptor mRNA in the Human Prostate Carcinoma Cell Line-LNCaP/A-Dep....Pages 315-330 DNA Methylation, Differentiation and Cancer....Pages 331-336 Evidence for the Involvement of Genetic Differences and Mesenchymal Factors in the Progression of Oncogene-Induced Prostate Cancer in Reconstituted Mouse Prostate....Pages 337-344 Differential Hybridization Analysis as a Tool to Study Prostatic Cancer Metastasis....Pages 345-354 Molecular Biology of Androgen Receptors in Prostate Cancer Cells....Pages 355-361 Back Matter....Pages 369-383