Molecular and Cell Biology of Human Gene Therapeutics (Molecular and Cell Biology of Human Diseases Series, 20)

advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu­ lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari­ ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro­ vides good palliation for the patient in a manner that differs essentially from chemotherapy.

written To Inform Not Only Basic Research Scientists And Students, But Also Practising Physicians, This Volume Reviews The Evolution Of Gene Transfer As A Therapeutic Strategy. The Latest Developments In Viral And Non-viral Vectors For Gene Therapy Are Explained. The Book Then Moves On To Describe Gene Therapy Applications In A Comprehensive Range Of Disease Situations Including Cancer, Aids, Arthritis, Cardiovascular And Neuromuscular Disorders, And Cystic Fibrosis As Well As Genetic Vaccination.

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addressed To Practicing Physicians As Well As Scientists And Advanced Students Engaged In Basic Research, Reviews The Evolution Of Gene Transfer As A Therapeutic Strategy. Reports The Latest Development In Viral And Non-viral Vectors, Then Describes Gene Therapy For A Range Of Conditions, Including Cancer, Aids, Arthritis, Cardiovascular And Neuromuscular Disorders, Muscular Dystrophy, Cystic Fibrosis, And Genetic Vaccination. Annotation C. Book News, Inc., Portland, Or (booknews.com)

Front Matter....Pages i-xv Retroviral vectors....Pages 1-19 Adenoviral vectors....Pages 20-32 Herpes simplex virus vectors....Pages 33-63 Liposome-mediated gene transfer....Pages 64-82 Intramuscular injection of plasmid DNA....Pages 83-103 Yeast artificial chromosome vectors....Pages 104-124 Gene transfer and cancer chemotherapy....Pages 125-139 Vaccine immunotherapy for cancer....Pages 140-156 Inherited immunodeficiencies....Pages 157-174 Anti-viral strategies....Pages 175-194 AIDS and HIV infection....Pages 195-236 Cystic fibrosis and lung diseases....Pages 237-251 Arthritis....Pages 252-260 Duchenne muscular dystrophy....Pages 261-280 Cardiovascular disease....Pages 281-300 Degenerative and inherited neurological disorders....Pages 301-349 Mucopolysaccharidosis....Pages 350-367 DNA-based immunization....Pages 368-387 Back Matter....Pages 388-403