Modern Trends in Human Leukemia VIII new results in clinical and biological research including pediatric oncology, organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie, Hamburg, June 18, 1988, and Wilsede, June 19-23, 1988 ; Wi

You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget. Front Matter....Pages I-LVII Front Matter....Pages 1-2 Molecular Analysis of Rearrangements in Philadelphia (Ph 1 ) Chromosome-Positive Leukemia....Pages 3-10 Interactions Between Hematopoietic Growth Factors: The Clinical Role of Combination Biotherapy....Pages 11-21 Front Matter....Pages 23-23 Introduction of Donald Pinkel....Pages 25-26 Species-Specific Therapy of Acute Lymphoid Leukemia....Pages 27-36 Current Issues and Future Directions in Marrow Transplantation....Pages 37-45 The Use of Long-term Bone Marrow Cultures (LTBMC) to Detect Hematotoxic Side Effects of Purging Methods....Pages 46-50 Clinicopathological Features and Prognostic Implications of Immunophenotypic Subgroups in Childhood ALL: Experience of the BFM-ALL Study 83....Pages 51-57 Current Approaches to Therapy for Childhood Lymphoblastic Leukemia: St. Jude Studies XI (1984–1988) and XII (1988)....Pages 58-64 Results of Three Polychemotherapy Programs in Non-Hodgkin’s Lymphomas....Pages 65-70 Results of Treatment in Children with B-Cell Lymphoma: Report on the Polish Leukemia/Lymphoma Study Group....Pages 71-74 Correlations of Clinical and Laboratory Data for Prognosis in Childhood Acute Lymphoblastic Leukemia....Pages 75-77 Central Nervous System Involvement in Non-Hodgkin’s Lymphomas....Pages 78-81 Targeted Plasma Drug Concentration: A New Therapeutic Approach to Relapsed Nonlymphoblastic Leukemia in Children....Pages 82-87 Use of All-trans Retinoic Acid in the Treatment of Acute Promyelocyte Leukemia....Pages 88-96 Simultaneous Presentation of B- and T-Cell Malignant Lymphoma....Pages 97-100 Phenotype Switch in Acute Leukemia Patients After Intensive Chemotherapy....Pages 101-103 Expression of Cell Differentiation Antigens as a Prognostic Factor in Acute Leukemia....Pages 104-108 Immunologic Subclassification of Acute Lymphoblastic Leukemia in Childhood and Prognosis (Modified BFM Protocol)....Pages 109-112 Constellations of Genetic Abnormalities Predict Clinical Outcome in Childhood Malignancies....Pages 113-120 Leukemia Cytogenetics in Children: Results of the German Therapy Studies....Pages 121-126 Front Matter....Pages 23-23 Cytostatic Influence of Thioproline on Peripheral Lymphocytes of Healthy Persons and Non-Hodgkin’s Lymphoma Patients....Pages 127-130 Diversity of Molecular Phenotypes in Acute Leukemias....Pages 131-133 Treatment of Chronic Myelogenous Leukemia with Interferons: Hematologic, Cellular, and Genetic Investigations....Pages 134-138 α Interferon in Myelodysplasia....Pages 139-140 Use of Investigational Drugs as Initial Therapy for Childhood Solid Tumors....Pages 141-148 Xenografts of Pediatric Solid Tumors: Predictive Intermediate Models?....Pages 149-155 Front Matter....Pages 157-157 Stromal-Hematopoietic Interrelationships: Maximov’s Ideas and Modern Models....Pages 159-167 Bone Marrow Stromal Cells in Myelodysplastic Syndromes and Acute Nonlymphocytic Leukemia....Pages 168-171 Growth and Development of Haemopoietic Cells: A Deterministic Process?....Pages 172-177 Limited Proliferative Potential of Primitive Hematopoietic Stem Cells: Hematopoiesis by Clonal Succession....Pages 178-182 The Effect of Human and Rat Fetal Bone on Hematopoiesis In Vitro and In Vivo....Pages 183-187 Aberrant Expression of the Multi-CSF Gene in Hematopoietic Precursor and Stem Cell Lines Initiates Leukemogenic Progression....Pages 188-196 Infection of Multipotent IL-3-dependent Stem Cells With a Retroviral Vector Containing the IL-3 Gene Confers Density-dependent Growth Autonomy Without Blocking Differentiation....Pages 197-205 Isolation of Revertants from a Factor-Independent Myeloid Cell Line....Pages 206-207 Comparison of Factors Which Induce Differentiation of the Murine Myeloid Leukaemic Cell Line M1....Pages 208-213 Establishment of a Leukemic Cell Line MT-ALL With Multilineage Differentiation Potential....Pages 214-219 Establishment of a Hybrid Cell System Between Malignant Burkitt’s Lymphoma Cells and Nonmalignant Lymphoblastoid Cells....Pages 220-222 Effect of Natural and Synthetic Peptides on the Biological Function of Leukemic Cells....Pages 223-225 Mechanisms of Glucocorticoid-Induced Growth Inhibition and Cell Lysis in Mouse Lymphoma Cells....Pages 226-232 Characteristics of 27 Human T-Cell Leukemia Cell Lines With/Without T-Cell Receptors of T3-Tiαβ or T3-Tiγδ Complex....Pages 233-236 Front Matter....Pages 157-157 Intervention in Potential Leukemic Cell Migration Pathway Affects Leukemogenesis....Pages 237-242 Preleukemia in Experimental Leukemogenesis....Pages 243-249 RAS Mutations in Preleukaemias....Pages 250-254 Front Matter....Pages 255-255 Logical Structure of the Immunoregulatory Compartment....Pages 257-259 Analysis of T Suppressor Cell-Mediated Tumor Escape Mechanisms Is Facilitated by the Selective In Vitro Activation of Tumor-specific Ts Cells....Pages 260-262 Role of the Colony-Stimulating Factor-1 Receptor (c- fms ) and Its Ligand in Oncogenesis....Pages 263-267 Activation of CD4-Positive T Cells by Polysaccharide Fractions Isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae).....Pages 268-272 Induction of Nonspecific Cell-Mediated Cytotoxicity: A Multisignal Event and its Cellular Regulation....Pages 273-280 Signal Transduction Mechanisms in Human Natural Killer Cells Mediating Antitumor Immunity....Pages 281-283 Tumor-Specific Antigens and Tumor-Specific Mutant Proteins in Mouse and Man....Pages 284-288 Modification of HLA Expression as a Possible Factor in the Pathogenesis of Burkitt’s Lymphoma....Pages 289-292 Disorders of the Expression of the Multichain IL-2 Receptor in HTLV-I-Associated Adult T-Cell Leukemia....Pages 293-298 Monocyte Interleukin-1 Secretion Is Regulated by the Sequential Action of γ-Interferon and Interleukin-2 Involving Monocyte Surface Expression of Interleukin-2 Receptors....Pages 299-315 The Expression of T-Cell Receptor-Associated Proteins in Normal and Leukaemic Immature T Cells....Pages 316-328 Front Matter....Pages 329-329 Molecular Analysis of the Translocation Breakpoint in a Philadelphia-positive, bcr-negative ALL Patient....Pages 331-334 Cloning of the Breakpoint Junction of the Translocation 14;19 in Chronic Lymphocytic Leukemia....Pages 335-336 Variant Breakpoint Positions on Chromosome 22 in Ph′-Positive Chronic Myelogenous Leukemias....Pages 337-338 Expression of Cellular Oncogenes in Primary Cells from Human Leukemias....Pages 339-342 c-myc and c-myb Oncoproteins During Induced Maturation of Human Myeloid and Erythroid Leukaemic Lines....Pages 343-346 Isolation and Characterisation of a Myeloid Leukaemia Inducing Strain of Feline Leukaemia Virus....Pages 347-351 Front Matter....Pages 329-329 Cell Lineage Specificity of Chromatin Configuration and Gene Expression in Haemopoietic Progenitor Cells....Pages 352-356 Chromosomal Translocations Involving the T-Cell Receptor δ Chain Locus and Two Loci on the Short Arm of Chromosome 11....Pages 357-359 Genetic Markers for Oncogenes, Growth Factors, and Cystic Fibrosis....Pages 360-365 Search for Genes Critical for the Early and/or Late Events in Carcinogenesis: Studies in Xiphophorus (Pisces, Teleostei)....Pages 366-385 ras Gene Mutations and Clonal Analysis Using RFLPs of X-chromosome Genes in Myelodysplastic Syndromes....Pages 386-389 Close Localization of the Genes for GM-CSF and IL3 in Human Genome....Pages 390-392 HIV-1, HTLV-I and the Interleukin-2 Receptor: Insights into Transcriptional Control....Pages 393-401 HIV-I Replication Requires an Intact Integrase Reading Frame....Pages 402-405 Use of a HIV-1 Retroviral Vector System for Gene Transfer into Human Cells....Pages 406-406 Multistage Mastocytoma Model Characterized by Autocrine IL-3 Production....Pages 407-410 Purified Bovine NF-κB Recognizes Regulatory Sequences in Multiple Genes Expressed During Activation of T- and B-Lymphocytes....Pages 411-415 Hematopoietic Growth Control by the T-Cell CD2 Determinant is Exerted at a Pretranslational Level....Pages 416-422 Oncogene Cooperation and B-Lymphoid Tumorigenesis in E μ - myc Transgenic Mice....Pages 423-427 Even Transcriptionally Competent Proviruses Are Silent in Bovine Leukemia Virus Induced Tumor Cells....Pages 428-432 Restriction Fragment Length Polymorphism of the c-Ha- ras -1 Proto-Oncogene as a Marker of Genome Alterations and Susceptibility to the Development of Some Human Carcinomas....Pages 433-435 Analysis of c- raf Oncogene Expression in Gastrointestinal Tumor Cells....Pages 436-440 c- ets -2 and the Mitogenic Signal Pathway....Pages 441-448 Induction of Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia Cells....Pages 449-452 Expression and Chromosomal Assignment of a Novel Protein-Tyrosine Kinase Gene Related to the Insulin Receptor Family....Pages 453-460 Genetic Characterization of a Human Endogenous Retroviral Element Located on Chromosome 18q21....Pages 461-463 Front Matter....Pages 329-329 Human Endogenous Retrovirus-like Sequences....Pages 464-477 Front Matter....Pages 479-479 Fantasy of a “Virus” from the Inorganic World: Pathogenesis of Cerebral Amyloidoses by Polymer Nucleating Agents and/or “Viruses”....Pages 481-499 Clay Minerals — Blueprints of Early Life....Pages 500-511 Modern Coding Sequences Are in the Periodic-to-Chaotic Transition....Pages 512-519 Translation to Human Temperaments of the Tyrosin-Kinase Active Site of the Human Insulin Receptor β-Chain....Pages 520-526 Back Matter....Pages 527-532 This book reports on the VIIIth Wilsede Meeting on Modern Trends in Human Leukemia held in June 1988. The contributions are divided into clinical, immunological, cell biological, virological and molecular genetic sections. The Wilsede Joint Meeting on Pediatric Oncology V is also included. The Frederick Stohlmann Lectures were given by Janet Rowley and Malcolm Moore, while C. Gajdusek gave a very special lecture on the fantasy of a virus from the inorganic world. Bone marrow transplantation, using haemopoetic growth factors and the diagnostic value of molecular genetics were discussed. The VIIIth Wilsede Meeting shows again that the new technologies achieved do not eliminate the old ones. This was discussed by Alexander Friedenstein shown in the results Alexander Maximov achieved in 1907. The book demonstrates the complexity of leukemia research as a tool for human biology. The book will be of value to both clinicians and researchers in many fields of oncology, as well as for investigators and students interested in human biology. Of further interest: R. Neth, R.C. Gallo, M.F. Greaves, Modern Trends in Human Leukemia - Vol. VI. 1985. ISBN 3-540-15329-2 - Vol. VII. 1987. ISBN 3-540-17754-X Edited By Rolf Neth ... [et Al.]. The Book Reports On The Viiith Wilsede Meeting On Modern Trends In Human Leukemia Held In June 1988 ... The Frederick Stohlman Lectures Were Given By Janet Rowley And Malcolm Moore, While C. Gajdusek Gave A Very Special Lecture On The Fantasy Of A Virus From The Inorganic World--p. [4] Of Cover. Organized On Behalf Of The Deutsche Gesellschaft Für Hämatologie Und Onkologie, Hamburg, June 18, 1988 And Wilsede, June 19-23, 1988 ; Wilsede Joint Meeting On Pediatric Oncology V, Hamburg, June 17, 1988. Includes Bibliographical References And Index. Organized on behalf of the Deutsche Gesellschaft fur Hamatologie und Onkologie, Hamburg, June 18, 1988 and Wilsede, June 19-23, 1988. Wilsede Joint Meeting on Pediatric Oncology V, Hamburg, June 17, 1988